Central Serotonin Receptors

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

1981 • 848 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Two Distinct Central Serotonin Receptors with Different Physiological Functions

1981 • 640 citations

Discrimination of Multiple [³H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

1981 • 629 citations

Serotonergic component of neuroleptic receptors

1978 • 621 citations

Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.

1976 • 494 citations

Tricyclic Antidepressants: Long-Term Treatment Increases Responsivity of Rat Forebrain Neurons to Serotonin

1978 • 476 citations

Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes.

1980 • 444 citations

Brain neurotransmitter receptors after long-term haloperidol: Dopamine, acetylcholine, serotonin, α-noradrenergic and naloxone receptors

1977 • 304 citations

Neurotransmitters and their receptors

1980 • 258 citations

Ionic mechanisms and receptor properties underlying the responses of molluscan neurones to 5‐hydroxytryptamine

1974 • 256 citations

Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain

1981 • 237 citations

Lithium Increases Serotonin Release and Decreases Serotonin Receptors in the Hippocampus

1981 • 236 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Serotonin release is modulated by presynaptic autoreceptors

1979 • 225 citations

Differential effects of antidepressant treatment on brain monoaminergic receptors

1980 • 222 citations

Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment.

1979 • 211 citations

Regulation of serotonin2 (5-HT2) receptors labeled with [3H]spiroperidol by chronic treatment with the antidepressant amitriptyline.

1980 • 207 citations

3H-spiroperidol labels serotonin receptors in rat cerebral cortex and hippocampus

1978 • 206 citations

Adenylate cyclase activation by the .beta.-adrenergic receptors as a diffusion-controlled process

1979 • 199 citations

Behavioral evidence for supersensitivity following destruction of central serotonergic nerve terminals by 5,7-dihydroxytryptamine.

1976 • 182 citations

Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain

1981 • 176 citations

Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors

1975 • 166 citations

Characterisation of Inhibitory 5‐Hydroxytryptamine Receptors That Modulate Dopamine Release in the Striatum

1981 • 162 citations

Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine

1977 • 155 citations

AROMATIC AMINO ACIDS IN THE BRAIN

1974 • 141 citations

[3H]Mianserin: differential labeling of serotonin and histamine receptors in rat brain.

1981 • 137 citations

Interaction of Benzodiazepines with Central Nervous Glycine Receptors: Possible Mechanism of Action

1974 • 136 citations

Serotonin-induced hyperpolarization of an indentified Aplysia neuron is mediated by cyclic AMP.

1980 • 133 citations

Serotonin. Current aspects of neurochemistry and function.

1981 • 124 citations

Enhancement of responsiveness of the central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment

1981 • 119 citations

Modifications of central 5-hydroxytryptamine binding sites in synaptic membranes from rat brain after long-term administration of tricyclic antidepressants

1979 • 119 citations

High-affinity binding of (3H) 5-hydroxytryptamine to brain synaptosomal membranes: comparison with (3H) lysergic acid diethylamide binding.

1978 • 116 citations

Serotonin-sensitive adenylate cyclase activity in immature rat brain

1975 • 115 citations

Extracellular 5-hydroxytryptamine inhibits 5-hydroxytryptamine release from rat brain cortex slices

1979 • 115 citations

SEPARATE 5‐HYDROXYTRYPTAMINE RECEPTORS ON THE SALIVARY GLAND OF THE BLOWFLY ARE LINKED TO THE GENERATION OF EITHER CYCLIC ADENOSINE 3‘,5’‐MONOPHOSPHATE OR CALCIUM SIGNALS

1981 • 111 citations

Serotonin receptor binding sites affected differentially by guanine nucleotides.

1979 • 108 citations

Multiple serotonin receptors: Regional distribution and effect of raphe lesions

1981 • 105 citations

Imipramine: Effect of Ovarian Steroids on Modifications in Serotonin Receptor Binding

1981 • 99 citations

The effects of quipazine on 5-HT metabolism in the rat brain

1976 • 99 citations

Serotonin-sensitive adenylate cyclase and [3]serotonin binding sites in the CNS of the rat—I

1980 • 98 citations

Postsynaptic serotonin-sensitive adenylate cyclase in the central nervous system. I. Development and distribution of serotonin and dopamine-sensitive adenylate cyclases in rat and guinea pig brain.

1978 • 97 citations

Substance P, but not TRH, modulates the 5-HT autoreceptor in ventral lumbar spinal cord

1981 • 93 citations

The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.

1980 • 92 citations

Calcium and the control of synaptic strength by learning

1981 • 92 citations

Further evidence for negative feedback control of serotonin release in the central nervous system

1981 • 91 citations

Monoaminergic denervation of the rat hippocampus: Microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin

1980 • 91 citations

Serotonin receptors in hippocampus and frontal cortex

1980 • 89 citations

Altered neuronal responsiveness to biogenic amines in rat cerebral cortex after serotonin denervation or depletion

1982 • 87 citations

SEROTONIN BINDING TO NERVE ENDING PARTICLES AND OTHER PREPARATIONS FROM RAT BRAIN*

1966 • 86 citations

Regulation of serotonin synthesis

1974 • 86 citations

Biochemical assessment of the central 5-HT agonist activity of RU 24969 (a piperidinyl indole)

1980 • 85 citations

Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors

1981 • 84 citations

PLASMA TRYPTOPHAN AND 5‐HT METABOLISM IN THE CNS OF THE NEWBORN RAT

1974 • 83 citations

Monoamine oxidase inhibitors and serotonin uptake inhibitors: differential effects on [3H]serotonin binding sites in rat brain.

1980 • 82 citations

Neuronal 5-hydroxytryptamine receptors outside the central nervous system

1981 • 78 citations

Hyper- and hyposensitivity of central serotonin receptors: [3H]serotonin binding and functional studies in the rat

1980 • 78 citations

Benzodiazepines: GABA and glycine receptors on single neurons in the rat medulla

1976 • 78 citations

A BIOCHEMICAL‐BEHAVIORAL MODEL FOR STUDYING SEROTONERGIC SUPERSENSITIVITY IN BRAIN

1979 • 73 citations

The effects of long-term ethanol on brain receptors for dopamine, acetylcholine, serotonin and noradrenaline

1980 • 71 citations

Electrical stimulation of the nucleus raphe magnus in the rat. Effects on 5-HT metabolism in the spinal cord

1980 • 65 citations

Postsynaptic serotonin-sensitive adenylate cyclase in the central nervous system. II. Comparison with dopamine- and isoproterenol-sensitive adenylate cyclases in rat brain.

1978 • 64 citations

Serotonin receptor localization in rat brain by light microscopic autoradiography

1980 • 63 citations

Is it possible to modify serotonin receptor sensitivity?

1978 • 59 citations

Characterization and radioautography of [3H] LSD binding by rat brain slices in vitro: The effect of 5-hydroxytryptamine

1980 • 56 citations

[³H]Metergoline: A New Ligand of Serotonin Receptors in the Rat Brain

1981 • 54 citations

Effect of p-chlorophenylalanine on cerebral serotonin binding, serotonin concentration and motor activity in the rat

1978 • 52 citations

[3H]5-HT binding sites and 5-HT-sensitive adenylate cyclase in glial cell membrane fraction

1980 • 51 citations

Decrease in [3H]-serotonin binding in rat brain produced by the repeated administration of either monoamine oxidase inhibitors or centrally acting serotonin agonists

1980 • 50 citations

Modulation of affinity of postsynaptic serotonin receptors by antidepressant drugs

1981 • 49 citations

Decrease of [³H]5‐HT high affinity binding and 5‐HT adenylate cyclase activation after kainic acid lesion in rat brain striatum

1979 • 49 citations

Serotonin-sensitive adenylate cyclase and [3H]serotonin binding sites in the CNS of the rat—II

1980 • 49 citations

Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings

1982 • 49 citations

Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs

1981 • 48 citations

Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on 3H-serotonin receptor binding in rat brain

1979 • 48 citations

The effects of chronic treatment with the 5-hydroxytryptamine uptake blocker zimelidine on central 5-hydroxytryptamine mechanisms. Evidence for the induction of a low affinity binding site for 5-hydroxytryptamine

1979 • 47 citations

Acute changes in central serotonin metabolism induced by the blockade or stimulation of serotoninergic receptors during ontogenesis in the rat.

1977 • 45 citations

Differential binding of 3H-imipramine and 3H-mianserin in rat cerebral cortex

1981 • 44 citations

The interaction of lisuride, an ergot derivative, with serotonergic and dopaminergic receptors in rabbit brain.

1981 • 43 citations

Ca²⁺‐Guanine Nucleotide Interactions in Brain Membranes. I. Modulation of Central 5‐Hydroxytryptamine Receptors in the Rat

1982 • 42 citations

Serotonin sensitive adenylate cyclase in horse brain synaptosomal membranes

1979 • 42 citations

K+-evoked [3H]-5-HT release from rat frontal cortex slices: the effect of 5-HT agonists and antagonists

1982 • 39 citations

Enhancement of 5-Hydroxytryptamine-induced behavioral effects following chronic administration of antidepressant drugs

1980 • 38 citations

Long-term treatment with zimelidine leads to a reduction in 5-hydroxytryptamine neurotransmission within the central nervous system of the mouse and rat

1981 • 38 citations

Alterations of serotonin and LSD receptor binding following repeated administration of LSD

1979 • 37 citations

Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus

1981 • 36 citations

Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus.

1981 • 36 citations

Characteristics of d-lysergic acid diethylamide binding to subcellular fractions derived from rat brain

1973 • 36 citations

In vitro and in vivo disposition of 3H-methiothepin in brain tissues

1979 • 33 citations

Effect of monoamine receptor agonists and antagonists on cyclic AMP accumulation in human cerebral cortex slices

1977 • 33 citations

Reduction in the number of serotonin receptors in the brainstem of morphine dependent rats: Relation to blockade of naloxone precipitated jumping by serotonin agonists

1980 • 32 citations

Long lasting effects of intrauterine growth retardation on 5-HT metabolism in the brain of developing rats

1981 • 30 citations

Effects of serotonin on extracellular potassium concentration in the rat hippocampal slice

1980 • 30 citations

Is there a connection between high affinity 3H-spiperone binding sites and DA-sensitive adenylate cyclase in corpus striatum ?

1980 • 28 citations

Differential effects of clomipramine and clorgyline on the sensitivity of cortical neurons to serotonin: Effect of chronic treatment

1981 • 27 citations

Supersensitivity of nigral serotonin receptors and rat rotational behaviour

1981 • 27 citations

Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?

1981 • 26 citations

Midbrain raphe lesion in the newborn rat: II. Biochemical alterations in serotoninergic innervation

1977 • 26 citations

Receptors: Localization and Specificity of Binding of Serotonin in the Central Nervous System

1971 • 25 citations

INCREASED CENTRAL 5‐HYDROXTRYPTAMINE RECEPTOR MECHANISMS IN RATS AFTER CHRONIC NEUROLEPTIC TREATMENT

1981 • 23 citations

Solubilization of serotonin receptors from rat frontal cortex

1980 • 22 citations

The in vivo and in vitro occupation of [3H]-spiperone binding sites in the frontal cortex and striatum by putative 5-hydroxytryptamine antagonists

1980 • 21 citations

The effect of acute raphe lesion on serotonin synthesis and metabolism in the rat forebrain and hippocampus

1976 • 20 citations

Does [3H]spiroperidol label a 5-HT receptor in the frontal cortex of the rat?

1980 • 19 citations

Treatment with trazodone plus phenoxybenzamine accelerates development of decreased type 2 serotonin binding in rat cortex

1981 • 18 citations

Serotonin binding to different regions of human brain

1981 • 17 citations

Direct binding of 3H-lisuride to adrenergic and serotonergic receptors

1981 • 15 citations

Ca²⁺‐Guanine Nucleotide Interactions in Brain Membranes. II. Characteristics of [³H]Guanosine Triphosphate and [³H]β, γ‐Imidoguanosine 5′‐Triphosphate Binding and Catabolism in the Rat Hippocampus and Striatum

1982 • 14 citations

Pharmacological characterization of 3H-LSD binding sites in mouse brain in vivo

1979 • 14 citations

Stimulation of adenylate cyclase activity in monkey anterior limbic cortex by serotonin

1978 • 14 citations

Does [3]serotonin label presynaptic receptors in rat frontal cortex?

1981 • 13 citations

The Action of Serotonin in the Rat Hippocampus

1981 • 12 citations

Effect of serotonin on cyclic AMP level in rat hypothalamus slices during development

1979 • 11 citations

The effect of GTP on benzodiazepine receptors

1982 • 11 citations

Long-term local and distal increases in tryptophan hydroxylase activity following intracerebral kainic acid injections in the rat

1982 • 8 citations

Metergoline antagonism of 5-hydroxytryptamine-induced activation of rat cerebral cortical (Na+-K+) ATPase

1979 • 7 citations

Characteristics of Serotonin Receptors in the Rat Brain

2015 • 6 citations

Identification of Serotonin-Binding Proteins Using a Photoaffinity Labeling Probe

1981 • 4 citations

The [3H]5-HT and [3H]spiroperidol binding sites in the rat frontal cortex are thermally inactivated at different rates

1981 • 1 citations

Brain Serotonin Receptors and Neuropsychiatric Disorders

1981 • 1 citations