Inhibitors Associated with the Proteinases of Mammalian Cells and Tissues

Lysosomes in biology and pathology

1977 • 2,068 citations

[31] Affinity chromatography

1971 • 1,407 citations

Proteases and biological control

1976 • 1,380 citations

Proteinases in mammalian cells and tissues

1978 • 701 citations

Platelets in Biology and Pathology

1981 • 644 citations

Proteinases in Mammalian Cells and Tissues

1977 • 537 citations

Synthesis of fibrinolytic activator and inhibitor by endothelial cells

1977 • 484 citations

Proteases and biological control

1975 • 412 citations

Role of proteolytic enzymes in biological regulation (a review).

1976 • 410 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Cathepsin L

1977 • 341 citations

Platelets in biology and pathology

1977 • 308 citations

Degradation of myofibrillar proteins by cathepsins B and D

1977 • 285 citations

Protein Turnover and Lysosome Function

1978 • 279 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

1978 • 267 citations

Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas

1978 • 260 citations

Nerve Growth Factor

1978 • 243 citations

Demonstration of an alpha2-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines.

1979 • 230 citations

Evidence that latent collagenases are enzyme-inhibitor complexes

1977 • 223 citations

The transport of lysosomal enzymes

1977 • 214 citations

Natural Proteinase Inhibitors

1968 • 202 citations

PROTEOLYTIC ENZYMES OF MAST CELLS*

1963 • 197 citations

Natural proteinase inhibitors

1968 • 185 citations

Purification and characterization of a collagenase extracted from rabbit tumours

1975 • 169 citations

Identification of two protease inhibitors from bovine cardiac muscle.

1978 • 163 citations

The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism

1978 • 159 citations

Immunofluorescent localization of a serine protease in rat small intestine.

1978 • 157 citations

A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts.

1979 • 157 citations

Muscular Dystrophy: Inhibition of Degeneration in Vivo with Protease Inhibitors

1978 • 151 citations

Interaction of human cathepsin D with the inhibitor pepstatin

1976 • 150 citations

Neutral metallo-proteinases of rabbit bone. Separation in latent forms of distinct enzymes that when activated degrade collagen, gelatin and proteoglycans

1978 • 149 citations

The possible role of neutrophil proteinases in damage to articular cartilage

1978 • 142 citations

Affinity Chromatography

1978 • 139 citations

Activities and cellular localization of yeast proteases and their inhibitors

1974 • 132 citations

Plasminogen activator activity in cultures from human tissues. An immunological and histochemical study

1969 • 127 citations

A Protein-Bound Form of Porcine Renal Renin

1974 • 122 citations

Purification and Properties of a New Cathepsin from Rat Liver1

1978 • 122 citations

Cathepsins B1 and D. Action on human cartilage proteoglycans

1973 • 120 citations

PURIFICATION AND PROPERTIES OF BEEF SPLEEN CATHEPSIN B

1957 • 119 citations

Acid Proteases: Structure, Function, and Biology

1977 • 116 citations

The Degradation of Human Glomerular Basement Membrane with Purified Lysosomal Proteinases: Evidence for the Pathogenic Role of the Polymorphonuclear Leucocyte in Glomerulonephritis

1978 • 115 citations

Inactivation of human α1-proteinase inhibitor by thiol proteinases

1977 • 112 citations

A major serine protease in rat skeletal muscle: Evidence for its mast cell origin

1978 • 107 citations

Isolation and Properties of Two Inhibitors of Proteinase B from Yeast

1974 • 102 citations

Uptake and degradation of α2-macroglobulin-protease complexes in human cells in culture

1978 • 102 citations

A renin inhibitor from rabbit kidney: conversion of a large inactive renin to a smaller active enzyme.

1975 • 101 citations

Calcium-dependent Golgi-vesicle fusion and cathepsin B in the conversion of proalbumin into albumin in rat liver

1978 • 100 citations

Mechanism of dexamethasone inhibition of plasminogen activator in rat hepatoma cells.

1978 • 97 citations

Thermostable Endogenous Inhibitors of Cathepsins B and H

1979 • 96 citations

Isolation of a Phospholipid Renin Inhibitor from Kidney^*

1967 • 96 citations

A protein inhibitor of the mitochondrial adenosine triphosphatase complex of rat liver. Purification and characterization.

1979 • 92 citations

Three yeast proteins that specifically inhibit yeast proteases A, B, and C

1975 • 91 citations

Relationship Between Elastolytic Activity and Experimental Emphysema-Inducing Properties of Papain Preparations^1,2

1974 • 91 citations

The detection and characterization of collagenase inhibitors from rabbit tissues in culture

1977 • 90 citations

Limited Proteolysis in Microorganisms

1978 • 90 citations

Proteinase inhibitors of bovine nasal cartilage

1978 • 90 citations

Proteolysis and Physiological Regulation

1976 • 89 citations

Characterization of a neutral protease from lysosomes of rabbit polymorphonuclear leucocytes

1971 • 86 citations

Acrosomal Proteinase and Proteinase Inhibitor of Human Spermatozoa

1972 • 86 citations

Epidermal growth factor: Internal duplication and probable relationship to pancreatic secretory trypsin inhibitor

1974 • 84 citations

Purification and Characterization of Macromolecular Inhibitors of Proteinase A from Yeast

1974 • 84 citations

Isolation of completely inactive plasma prorenin and its activation by kallikreins

1979 • 84 citations

Characterization of peptic inhibitory activity associated with sulfated glycoprotein isolated from gastric mucosa

1979 • 83 citations

Solitary cells and enzyme exchange in tetraparental mice

1976 • 82 citations

Rabbit bone collagenase inhibitor blocks the activity of other neutral metalloproteinases

1979 • 80 citations

The Occurrence of an Inhibitor of Ca2+-Dependent Neutral Protease in Rat Liver1

1978 • 80 citations

The Intracellular Neutral SH-Dependent Protease Associated with Inflammatory Reactions

1975 • 79 citations

Purification and Properties of Two Protease Inhibitors from Rat Skin Inhibiting Papain and Other SH-Proteases.

1976 • 76 citations

Regulatory Proteolytic Enzymes and their Inhibitors

1978 • 75 citations

Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysis

1979 • 73 citations

Separation of a new alpha-N-benzoylarginine-beta-naphthylamide hydrolase from cathepsin B1. Purification, characterization, and properties of both enzymes from rabbit lung.

1978 • 73 citations

Characterization of the High Molecular Weight Form of Epidermal Growth Factor

1974 • 72 citations

The purification of bovine cathepsin B1 and its mode of action on bovine collagens

1974 • 70 citations

A new serum component which specifically inhibits thiol proteinases

1977 • 67 citations

Compartmentation of inhibitors of proteinases A and B and carboxypeptidase Y in yeast

1974 • 67 citations

Isolation of a Protease Inhibitor from Tissues Resistant to Tumor Invasion

1977 • 66 citations

Primary structural analysis of sulfhydryl protease inhibitors from pineapple stem.

1975 • 65 citations

Plasma‐kinin‐forming enzymes in body fluids and tissues

1959 • 64 citations

alpha-N-Benzoylarginine-2-naphthylamide Hydrolase (Cathepsin B1 ?) from Rat Skin. II. Purification of the Enzyme and Demonstration of Two Inhibitors in the Skin.

1975 • 62 citations

Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart

1979 • 61 citations

Elevated levels of a calcium-activated muscle protease in rapidly atrophying muscles from vitamin E-deficient rabbits

1979 • 61 citations

Identification of Human Glandular Kallikrein in the Beta Cell of the Pancreas

1979 • 60 citations

Lysosomal Cathepsin B1: Partial Characterization in Rat Preputial Gland and Recompartmentation in Response to Estradiol‐17β

1976 • 58 citations

Platelet alpha2-macroglobulin and alpha1-antitrypsin.

1976 • 58 citations

Extracellular hydrolases of the lung

1978 • 57 citations

Further purification of a protease inhibitor from rabbit skin with healing inflammation

1965 • 57 citations

Nerve growth factor: a protease that can activate plasminogen.

1978 • 56 citations

A protein reminiscent of the epidermal SH-protease inhibitor occurs in squamous epithelia of man and rat

1978 • 56 citations

The inactivation of native enzymes by a neutral proteinase from rat intestinal muscle

1978 • 55 citations

Yeast proteinase B: Identification of the inactive form as an enzyme-inhibitor complex

1969 • 55 citations

Intracellular Distribution of Proteolytic Enzymes in Rat Liver Tissue.

1957 • 53 citations

Proteases and Protease Inhibitors in Chronic Obstructive Lung Disease

1978 • 52 citations

Elevated serum cathepsin B1-like activity in women with neoplastic disease

1979 • 52 citations

Proteolytic Enzymes and Endogenous Trypsin Inhibitor in Germinating Lettuce Seeds

1965 • 52 citations

Intracellular Distribution of Neutral Proteinases and Inhibitors in Pig Leucocytes. Isolation of Two Inhibitors of Neutral Proteinases

1975 • 51 citations

A Kallikrein-Specific Inhibitor in Rat Kidney Tubules

1976 • 51 citations

On the Mechanism of Activation of Phosphorylase b Kinase by Calcium

1968 • 49 citations

Latent proteinase activity of gamma-glutamyl transpeptidase light subunit.

1979 • 46 citations

Inhibition studies of an intracellular inhibitor on thiol proteinases

1978 • 45 citations

Increased calcium-activated neutral protease activity in muscles of dystrophic hamsters and mice

1979 • 45 citations

Characterization of a protein inhibitor of intracellular protease fromBacillus subtilis

1977 • 44 citations

The Low-Molecular-Weight SH-Protease Inhibitor in Rat Skin is Epidermal

1978 • 44 citations

Elevated serum cathepsin B1 and vaginal pathology after prenatal DES exposure.

1978 • 42 citations

Elution Volume versus Reciprocal Elution Volume in the Interpretation of Gel-filtration Experiments

1966 • 42 citations

Lysosomal enzymuria in the testosterone-treated mouse. A manifestation of cell defecation of residual bodies.

1978 • 42 citations

Bestimmung der Molekulargewichte von neuen Trypsin-Inhibitoren mit Hilfe der Sephadex-Gelfiltration

1965 • 42 citations

Intracellular Protein Catabolism II

1977 • 42 citations

Purification and characterization of rat liver lysosomal cathepsin B2

1974 • 39 citations

Proteolytic enzymes of rat liver mitochondria. Evidence for a mast cell origin

1979 • 39 citations

Synthesis of a collagenase inhibitor by smooth muscle cells in culture

1978 • 38 citations

Human skin proteases

1976 • 37 citations

BIOCHEMICAL STUDY OF CELLULAR ANTIGEN-ANTIBODY REACTION IN TISSUE CULTURE

1960 • 37 citations

Separation of a new protease from cathepsin B1 of rat liver lysosomes

1976 • 36 citations

Isolation and partial characterization of an endogenous inhibitor of ceramide glycosyltransferases from rat brain.

1978 • 34 citations

Human skin proteases

1972 • 31 citations

Ribonuclease-Inhibitor System Abnormality in Dystrophic Mouse Skeletal Muscle

1970 • 31 citations

Fractionation of the rat liver enzymes that hydrolyze benzoyl-arginine-2-naphthylamide

1975 • 29 citations

Early elevation of cathepsin B1 in human muscle disease

1977 • 28 citations

Serine proteinases and their inhibitors in Phycomyces blakesleeanus.

1979 • 28 citations

Mechanism and Regulation of Protein Turnover in Animal Cells

1976 • 27 citations

Inhibition of the Elastase-Like Esterase in Human Leukocyte Granules by Human Leukocyte Cell Sap

1971 • 27 citations

Proteolytic activity of nerve growth factor: a case of autocatalytic activation

1979 • 27 citations

Proteinase and proteinase-inhibitor activities of rat uterine myometrium during pregnancy and involution

1979 • 26 citations

Some properties of alkaline protease in rat muscle compared with that in peritoneal cavity cells.

1976 • 24 citations

Removal of a bound ligand from a macromolecule by gel filtration

1976 • 23 citations

α-N-Benzoylarginine-β-naphthylamide Amidohydrolase of Rat Liver Lysosomes

1972 • 23 citations

The proteolytic enzyme system of skin

1958 • 23 citations

Migration of rapidly-equilibrating systems comprising two reactants with equal velocities

1965 • 22 citations

The Localization of an Intracellular Membrane-Bound Proteinase from Rat Liver

1978 • 21 citations

Further studies of an inactive form of a trypsin-like enzyme in rabbit testes

1973 • 20 citations

In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide

1978 • 20 citations

Molecular-weight determination of a protease inhibitor from rabbit skin with healing inflammation

1965 • 20 citations

Further studies on an esterase inhibitor in human leukocyte cytosol.

1971 • 19 citations

The interactiion of a trypsin-dependent neutral protease and its inhibitor found in tumour cells Analysis of complex kinetic data involved in a thiol-disulphide exchange mechanism

1978 • 17 citations

Identification of glycoprotein, and antithrombin III as components of normal and malignant human tissues

1977 • 17 citations

A mosquito-chymotrypsin inhibitor in tissues of adult Aedes aegypti

1972 • 16 citations

The Identification, Properties and Subcellular Distribution of Cathepsins B1 and C (Dipeptidyl Aminopeptidase 1) in Human Peripheral-Blood Leucocytes

1974 • 16 citations

Continuous fluorometric assay for cathepsin B-like activity in lysosomes

1972 • 14 citations

An Acrosin Inhibitor in Ram Spermatozoa that Does Not Originate from the Seminal Plasma

1975 • 14 citations

The Occurrence of a Neutral Protease and Its Inhibitor in Rat Peritoneal Macrophages1

1977 • 13 citations

The reversible thiol-disulphide exchange of trypsin and chymotrypsinogen with a tumour-derived inhibitor Kinetic data obtained with fluorescein-labelled polymeric collagen fibrils and casein as substrates

1979 • 12 citations

Human‐Polymorphonuclear‐Leucocyte Neutral Protease and Its Inhibitor

1976 • 12 citations

An inhibitor protein of nuclear protein kinases

1979 • 12 citations

A Chromatin-Bound Neutral Protease and Its Inhibitor in Rat Peritoneal Macrophages1

1978 • 12 citations

Inhibition of Autolytic Breakdown of Muscle Proteins by the Sarcoplasm and the Serum of Rat

1969 • 11 citations

Large scale separation of protease inhibitors from malignant human breast tissue

1977 • 9 citations

Über die Reaktion de Kallikrein-Inaktivators mit Elastin

1966 • 7 citations

alpha-N-Benzoylarginine-2-naphthylamide Hydrolase (Cathepsin B1?) from Rat Skin. III. Substrate Specificity, Modifier Characteristics, and Transfomation of the Enzyme at Acidic pH.

1976 • 7 citations

A deoxyribonucleic acid binding protein from KB cells which inhibits deoxyribonuclease activity on single-stranded DNA.

1979 • 7 citations

[On the reaction of kallikrein inactivator with elastin].

1966 • 6 citations

A New Inhibitor Protein from Rat Uterus against Yeast Proteinase B

1978 • 6 citations

An Endogenous Inhibitor of the Neutral Proteinase from Rat Intestinal Smooth Muscle

1978 • 3 citations