Mechanism and Regulation of Protein Turnover in Animal Cells

Mammalian Protein Metabolism

1964 • 3,199 citations

Functions of Lysosomes

1966 • 2,942 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

THE LARGE-SCALE SEPARATION OF PEROXISOMES, MITOCHONDRIA, AND LYSOSOMES FROM THE LIVERS OF RATS INJECTED WITH TRITON WR-1339

1968 • 1,112 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Lysosomes and storage diseases

1973 • 745 citations

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.

1968 • 742 citations

The Dynamic State of Body Constituents.

1942 • 735 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

The Importance of Both Synthesis and Degradation in the Control of Arginase Levels in Rat Liver

1964 • 396 citations

A convenient, rapid and sensitive method for measuring the incorporation of radioactive amino acids into protein

1960 • 332 citations

Enzyme synthesis and degradation in mammalian systems

1971 • 310 citations

Digestive Activity of Lysosomes

1968 • 254 citations

Compartmentation of Free Valine and Its Relation to Protein Turnover in Perfused Rat Liver

1972 • 231 citations

Metabolic Interconversion of Enzymes

1972 • 228 citations

Digestive Activity of Lysosomes

1968 • 219 citations

Direct evidence of importance of lysosomes in degradation of intracellular proteins

1975 • 209 citations

Intracellular protein turnover

1976 • 202 citations

Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine.

1976 • 192 citations

Relationship between in vivo degradative rates and isoelectric points of proteins.

1975 • 171 citations

Studies on the Correlation between Size and Relative Degradation Rate of Soluble Proteins

1973 • 165 citations

Catabolism of Desialylated Ceruloplasmin in the Liver

1970 • 163 citations

Quantitative studies of pinocytosis. I. Kinetics of uptake of (125I)polyvinylpyrrolidone by rat yolk sac cultured in vitro.

1975 • 151 citations

Glycoprotein catabolism in rat liver. Lysosomal digestion of iodinated asialo-fetuin

1975 • 145 citations

THE FATE OF PEPTIDES PINOCYTOSED BY MACROPHAGES IN VITRO

1969 • 127 citations

On the Roles of Synthesis and Degradation in Regulation of Enzyme Levels in Mammalian Tissues* *Some of the studies described in this paper were supported by research grant GM14931 from the National Institute of General Medical Sciences, and research grant P-427 from the American Cancer Society.

1969 • 110 citations

Biochemical Regulatory Mechanisms in Eukaryotic Cells

1973 • 102 citations

Quantitative studies of pinocytosis. II. Kinetics of protein uptake and digestion by rat yolk sac cultured in vitro.

1975 • 101 citations

A statistical analysis of the relationship between degradative rates and molecular weights of proteins

1975 • 97 citations

Kinetic Aspects of Assembly and Degradation of Proteins

1956 • 89 citations

Protein substrate conformation and proteolysis.

1965 • 81 citations

Coenzyme dissociation, a possible determinant of short half-life of inducible enzymes in mammalian liver

1973 • 81 citations

Relationship between Degradation Rates of Proteins in Vivo and Their Susceptibility to Lysosomal Proteases

1974 • 77 citations

Lysosomal Enzymes as Agents of Turnover of Soluble Cytoplasmic Proteins

1975 • 69 citations

Rate Behavior of Metabolic Systems

1952 • 69 citations

Some characteristics of the alanine aminotransferase- and arginase-inactivating system of lysosomes

1972 • 67 citations

Metabolic Interconversion of Enzymes

1972 • 66 citations

A study of permeability of lysosomes to amino acids and small peptides

1971 • 66 citations

Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes

1975 • 64 citations

A comparison of the proteolytic susceptibility of several rat liver enzymes

1971 • 63 citations

Effect of ATP on Protein Degradation in Rat Liver Lysosomes

1973 • 50 citations

Ligand-induced Resistance of Staphylococcal Nuclease and Nuclease-T to Proteolysis by Subtilisin, α-Chymotrypsin, and Thermolysin

1969 • 44 citations

Further evidence for a proton pump in mouse kidney phagolysosomes: Effect of nigericin and 2,4-dinitrophenol on the stimulation of intralysosomal proteolysis by ATP

1975 • 44 citations

Purification and physiological role of a peptide stabilizing factor of rat liver phosphofructokinase.

1976 • 44 citations

What determines the half-life of proteins in, vivo? Some experiences with alanine aminotransferase of rat tissues

1969 • 42 citations

Localization of products of endogenous proteolysis in lysosomes of perfused rat liver

1974 • 38 citations

Inactivation of tyrosine aminotransferase in neutral homogenates and rat liver slices

1972 • 27 citations

Insulin degradation by lysosomal extracts from rat liver; model for a role of lysosomes in hormone degradation

1976 • 27 citations

Biochemical regulatory mechanisms in eukaryotic cells

1972 • 22 citations

Über die katheptische Inaktivierung einiger Enzyme der Rattenleber, insbesondere der Glucokinase

1967 • 22 citations

Studies on the Composition of Lysosomes

1965 • 19 citations

Regulation of intracellular enzyme levels by limited proteolysis

1975 • 18 citations

Proteolysis at neutral pH in a lysosomal‐cytosol system can not be attributed to the uptake of proteins into lysosomes

1974 • 16 citations

Facilitation of lysosome disruption by ATP at low pH

1974 • 15 citations

Inaktivierung mikrosomaler Proteine durch Lysosomen

1973 • 8 citations