Exploitable Aspects of Central Cholinergic Functions, Particularly with Respect to the EEG, Motor, Analgesic and Mental Functions

The Sciences of the Artificial

1969 • 11,821 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

Design for a Brain

1952 • 1,473 citations

Human Memory and the Cholinergic System

1974 • 1,378 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Ann Arbor, Michigan

1969 • 1,061 citations

THE CHOLINERGIC LIMBIC SYSTEM: PROJECTIONS TO HIPPOCAMPAL FORMATION, MEDIAL CORTEX, NUCLEI OF THE ASCENDING CHOLINERGIC RETICULAR SYSTEM, AND THE SUBFORNICAL ORGAN AND SUPRA-OPTIC CREST

1967 • 966 citations

Psychopharmacology. A Review of Progress, 1957-1967

1969 • 844 citations

Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital

1975 • 765 citations

The significance of the rabbit's septum as a relay station between the midbrain and the hippocampus I. The control of hippocampus arousal activity by the septum cells

1962 • 756 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

Cholinergic Mechanisms

1981 • 609 citations

Self-Organizing Systems

1961 • 604 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

Alcohol Intoxication and Withdrawal

1976 • 481 citations

Antischizophrenic Drugs and Brain Cholinergic Receptors

1974 • 474 citations

Eating or Drinking Elicited by Direct Adrenergic or Cholinergic Stimulation of Hypothalamus

1960 • 449 citations

Neocortical and hippocampal activation in relation to behavior: Effects of atropine, eserine, phenothiazines, and amphetamine.

1975 • 427 citations

Self-Stimulation of the Brain

1958 • 403 citations

Biology of cholinergic function

1977 • 368 citations

Behavioral and electroencephalographic effects of atropine and related compounds.

1966 • 355 citations

Memory and the Hippocampal Complex

1966 • 334 citations

Advances in Sleep Research.

1974 • 320 citations

PSYCHIATRIC SEQUELÆ OF CHRONIC EXPOSURE TO ORGANOPHOSPHORUS INSECTICIDES

1961 • 314 citations

Sleep Physiology and Pathology.

1969 • 297 citations

Neuro-Psychopharmacology.

1960 • 277 citations

Pharmacologic Dissociation of Behavior and EEG "Sleep Patterns" in Dogs: Morphine, N-Allylnormorphine, and Atropine

1952 • 263 citations

Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces

1975 • 242 citations

Effects of dopaminergic receptor agonists and antagonists on the activity of the neo-striatal cholinergic system

1975 • 236 citations

Modification of Morphine Withdrawal by Drugs interacting with Humoral Mechanisms: Some Contradictions and their Interpretation

1972 • 233 citations

REM Sleep Induction by Physostigmine Infusion During Sleep

1976 • 230 citations

Parasympathetic Suppression of Manic Symptoms by Physostigmine

1973 • 227 citations

Handbook of Drug and Chemical Stimulation of the Brain

1976 • 222 citations

Synaptic mechanisms in the substantia nigra

1976 • 217 citations

Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.

1973 • 213 citations

Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice.

1975 • 213 citations

Scientific Basis of Drug Dependence

1970 • 199 citations

Reduced effect of morphine in midbrain raphe lesioned rats

1970 • 197 citations

THE INHIBITION OF THE CONDITIONED RESPONSE AND THE COUNTERACTION OF SCHIZOPHRENIA BY MUSCARINIC STIMULATION OF THE BRAIN

1957 • 191 citations

Bed with bedpan.

1958 • 189 citations

Reciprocal Hunger-Regulating Circuits Involving Alpha-and Beta-Adrenergic Receptors Located, Respectively, in the Ventromedial and Lateral Hypothalamus

1970 • 187 citations

CEAN-computerized EEG analysis

1977 • 186 citations

Sleep cycle control and cholinergic mechanisms: Differential effects of carbachol injections at pontine brain stem sites

1975 • 186 citations

Psychomotor Activity in Affective States

1974 • 183 citations

Nicotinic effect of acetylcholine on the release of newly synthesized [3H]dopamine in rat striatal slices and cat caudate nucleus

1976 • 180 citations

Choline acetylase and glutamic acid decarboxylase in Huntington's chorea

1973 • 180 citations

The “caudate-spindle” IV. A behavioral index of caudate-induced inhibition

1961 • 180 citations

A pharmacological model of paradoxical sleep: The role of cholinergic and monoamine systems

1970 • 162 citations

The “caudate-spindle” I. electrophysiological properties

1961 • 159 citations

Biology of cholinergic function

1976 • 154 citations

Central cholinergic‐anticholinergic antagonism in Huntington's chorea

1972 • 150 citations

A General Theory of the Genesis of Drug Dependence by Induction of Receptors

1965 • 149 citations

Brain and Human Behavior

1972 • 147 citations

Cholinergic seizure kindling in the rat: Comparison of caudate, amygdala and hippocampus

1975 • 145 citations

The role of the neurotransmitters in the epilepsies.

1975 • 143 citations

A comparative study of haloperidol and chlorpromazine in terms of clinical effects and therapeutic reversal with benztropine in schizophrenia. Theoretical implications for potency differences among neuroleptics

1975 • 142 citations

Lesions in the medial forebrain bundle: Relationship between pain sensitivity and telencephalic content of serotonin.

1971 • 136 citations

Interaction of drugs with norepinephrine in the brain.

1959 • 131 citations

Cholinergic Mechanism Involved in Function of Mesodiencephalic Activating System

1955 • 130 citations

Post-reinforcement EEG synchronization during alimentary behavior

1964 • 117 citations

Psychobiology of Convulsive Therapy

1975 • 114 citations

Cholinergic and dopaminergic mechanisms in Huntington's chorea

1971 • 112 citations

Cholinesterasic striatopallidal and striatonigral efferents in the cat and the monkey

1970 • 110 citations

Muscarinic synapses in the hypothalamus

1962 • 107 citations

Role of Cholinergic Mechanisms in States of Wakefulness and Sleep

1968 • 98 citations

Sleep EEG Studies in Untreated, Long-Term Schizophrenic Patients

1973 • 94 citations

Physiology and Pathology

1978 • 88 citations

Pharmacological and Biophysical Agents and Behavior

1971 • 88 citations

Cholinergic suppression of tardive dyskinesia

1974 • 87 citations

Action of eserine and amphetamine on the electrical activity of the rabbit brain.

1957 • 84 citations

Interaction between cholinergic and catecholaminergic agents in a spontaneous alternation task

1976 • 82 citations

Effects of intraventriculary injected 6-OH dopamine or midbrain raphe lesion on morphine analgesia in rats

1972 • 81 citations

Physostigmine in choreiform movement disorders

1974 • 80 citations

Psychobiology of convulsive therapy

1974 • 75 citations

Functional antagonism between diffuse reticular and intralaminary recruiting projections in the medial thalamus

1960 • 74 citations

CHOLINERGIC TRANSMISSION AND ACETYLCHOLINE OUTPUT

1963 • 73 citations

Mixed depressant and stimulant actions of morphine and their relationship to brain acetylcholine

1976 • 71 citations

Neurotransmitter balances regulating behavior

1975 • 70 citations

Antinociceptive action of quipazine: Relation to central serotonergic receptor stimulation

1976 • 68 citations

Sleep Disturbance in Schizophrenia

1975 • 67 citations

Behaviorally Evoked Hippocampal Theta Waves: a Cholinergic Response

1975 • 66 citations

ACTION OF NICOTINE ON SPONTANEOUS AND ACQUIRED BEHAVIOR IN RATS AND MICE*

1967 • 66 citations

Acetylcholine Sensitivity of Hippocampal Formation Neurons

1974 • 66 citations

Behavioral Effects of Atropine and Scopolamine

1971 • 65 citations

Huntington's Disease: Regional alteration in muscarinic cholinergic receptor binding in human brain

1976 • 65 citations

Effects of acute and chronic morphine on regional rat brain acetylcholine turnover rate

1974 • 64 citations

Neuropsychopharmacology

1963 • 64 citations

Differential effects of scopolamine and chlorpromazine on REM and NREM sleep in normal male subiects

1969 • 64 citations

Alcohol Intoxication and Withdrawal, Experimental Studies

1974 • 63 citations

Psychomotor activity as a correlate of Depression and sleep in acutely disturbed psychiatric inpatients

1975 • 61 citations

Scientific basis of drug dependence

1971 • 61 citations

The presynaptic site of action of norepinephrine in the superior cervical ganglion of guinea pig.

1977 • 58 citations

Hippocampal electrical correlates of free behavior and behavior induced by stimulation of two hypothalamic-hippocampal systems in the cat

1975 • 58 citations

Effects of pilocarpine or arecoline administration on acetylcholine levels and serotonin turnover in rat brain.

1972 • 57 citations

Central Cholinergic Mechanism and Behavior

1971 • 53 citations

SOME OBSERVATIONS ON THE PSYCHOLOGY (AND SOME FEWER, ON THE BIOLOGY) OF SCHIZOPHRENIA

1971 • 51 citations

SLEEP AND ACTIVITY IN A PSYCHOTIC DEPRESSION

1973 • 50 citations

HISTOCHEMICAL VISUALIZATION OF PERIPHERAL AND CENTRAL ADRENERGIC NEURONES

1973 • 50 citations

The influence of raphe lesions on the effect of morphine on nociception and cortical ACh output

1975 • 50 citations

Pharmacology and the Future of Man

1974 • 48 citations

Man's aggression;: The defense of the self

1973 • 48 citations

Advances in Neuropharmacology

2020 • 47 citations

Aggression and Central Neurotransmitters

1975 • 44 citations

The release of acetylcholine into the cerebral subarachnoid space of anaesthetized cats

1965 • 43 citations

Neurochemical correlates of alcohol preference in inbred strains of mice

1975 • 43 citations

Neurotransmitter function

2024 • 42 citations

Oxotremorine- and atropine-induced changes of dopamine metabolism in the rat striatum

1975 • 41 citations

THE EFFECTS OF ACETYLCHOLINE AND DOPAMINE ON THE CAUDATE NUCLEUS DEPLETED OF BIOGENIC AMINES

1975 • 39 citations

Antagonism of the antiavoidance effects of various agents by anticholinergic drugs.

1970 • 38 citations

CHOLINERGIC BLOCKADE AS AN APPROACH TO THE DEVELOPMENT OF NEW PSYCHOTROPIC AGENTS

1962 • 38 citations

Central nervous system : studies on metabolic regulation and function

1974 • 38 citations

Alteration in nicotinic and muscarinic responses of rabbit superior cervical ganglion cells after chronic preganglionic denervation

1976 • 37 citations

Parasympathetlc Neurohumors; Posslble Precursors and Effect on Behavior

1959 • 36 citations

Hippocampal influence on hyperreactivity induced by septal lesions

1975 • 36 citations

The “caudate-spindle” III. Inhibition by high frequency stimulation of subcortical structures

1961 • 36 citations

Correlation between the experimental data from animal studies and therapeutical effects of antidepressant drugs

1971 • 35 citations

Effects of repeated doses of scopolamine on the electroencephalographic stages of sleep in normal volunteers

1975 • 34 citations

Models of human neurological diseases

1975 • 34 citations

Some Monoaminergic Mechanisms Controlling Sleep and Waking

1972 • 33 citations

A pharmacological analysis of processes underlying differential responding: a review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine

1976 • 32 citations

Introduction to Pharmacology

2020 • 32 citations

Effects of cholinergic and anticholinergic drugs and a partial cholinergic agonist on the development and expression of physical dependence on morphine in rat.

1975 • 32 citations

Brain acetylcholine and choline following acute and chronic morphine treatment and during withdrawal.

1975 • 29 citations

The subacute toxicity of four organic phosphates to dogs

1959 • 29 citations

Septal afterdischarges and their modification by the cerebellum

1975 • 28 citations

Rebound Phenomena in Manic Patients following Physostigmine

1975 • 28 citations

Catecholamines and Schizophrenia

1975 • 28 citations

Intraventricular anti-cholinergics do not block cholinergic hippocampal RSA or neocortical desynchronization in the rabbit or rat

1976 • 28 citations

Evidence for peripheral cholinergic components in thirst-induced water consumption

1969 • 27 citations

An application of long-term frequency analysis in measuring drug-specific alterations in the EEG of the cat

1975 • 27 citations

A longitudinal therapeutic comparison between two prototypic neuroleptics (haloperidol and chlorpromazine) in matched groups of schizophrenics. Nontherapeutic interactions with trihexyphenidyl. Theoretical implications for potency differences

1975 • 26 citations

Effects of morphine on brain and spinal acetyclholine levels and nociceptive threshold in the frog

1974 • 25 citations

Physostigmine Reversal of Antihistamine-induced Excitement and Depression

1975 • 25 citations

Model Systems in Biological Psychiatry

1976 • 24 citations

Effects of intraventricular 6-hydroxydopamine and replacement therapy with norepinephrine, dopamine, and serotonin on self-stimulation in diencephalic and mesencephalic regions in the rat

1975 • 23 citations

An effect of physostigmine on the central nervous system of rabbits, related to brain levels of norepinephrine

1971 • 23 citations

Dissociation of EEG and behavioural effects of ethanol provide evidence for a noncholinergic basis of intoxication

1974 • 22 citations

Cholinergic mechanism determines the occurrence of Reward Contingent Positive Variation (RCPV) in cat

1971 • 22 citations

Cellular Pharmacology of Ganglionic Transmission

1976 • 21 citations

Central cholinergic suppression of hyper-reactivity and aggression in septal-lesioned rats

1972 • 20 citations

Effects of Ethanol on Electrolyte Metabolism and Neurotransmitter Release in the CNS

1975 • 19 citations

Extension of tranquilizer action by anticholinesterases

1964 • 19 citations

The role of hippocampal cholinergic mechanisms in the aquisition of a barpress response

1976 • 18 citations

Electrophysiological analysis of the neuroleptic and antidepressant actions of psychotropic drugs in rabbits

1964 • 17 citations

Brain acetylcholine in morphine pellet implanted rats given naloxone

1975 • 17 citations

Behavioral inhibition induced by pallidal stimulation in monkeys

1975 • 16 citations

Brain choline acetylase and monoamine oxidase activity in normal and aggressive mice

1970 • 16 citations

Cholinergic modification of ethanol-induced electroencephalographic synchrony in the rat

1976 • 16 citations

Anorexia nervosa: Telemetric assessment of family interaction and hospital events

1975 • 16 citations

Reward contingent positive variation (RCPV) and post-reinforcement EEG synchronization (PRS) in the cat: Physiological aspects, the effect of morphine and LSD-25, and a new interpretation of cholinergic mechanisms

1976 • 15 citations

Cholinergic modulation of an opposed effect of d-amphetamine and methylphenidate on the rearing response

1975 • 15 citations

Taste phenomena and drug effects on thirst-induced fluid consumption by rats

1972 • 14 citations

Agression intraspécifique induite par chocsélectriques et réactivitéaprès lésion du raphéchez le rat. Effets de la physostigmine

1976 • 13 citations

Food deprivation at weaning and adult behavior elicited by hypothalamic stimulation in the rat

1976 • 13 citations

Neurosciences research. 4

1973 • 13 citations

Neurophysiological and Behavioral Aspects of Psychotropic Drugs

1970 • 13 citations

Electrocortical activity cholinergic stimulation of the caudate nucleus in the cat

1969 • 13 citations

Cholinergic modification of abnormal involuntary movements induced in the guinea-pig by intrastriatal dopamine

1975 • 11 citations

Tumor Sites in Cases of Brain Tumor with Mitten Patterns in the Electroencephalogram

1973 • 9 citations

Modification of evoked responses in the caudate nucleus by cholinergic agents

1976 • 9 citations

Models of human neurological diseases

1974 • 9 citations

The role of central cholinergic mechanisms in schizophrenia

1975 • 8 citations

The interaction of Δ9-tetrahydrocannabinol with cholinomimetic drugs in an agonist-antagonist paradigm

1976 • 8 citations

Biochemical pharmacology of brain amine mechanisms.

1975 • 7 citations

[Pilot study on the effects of an antiparkinson anticholinergic agent during depressive conditions].

1975 • 6 citations

Proceedings: The EEG in alkylphosphate poisoning (anticholinesterase insecticides).

1975 • 6 citations

Anorexigenic Action of Methylphenidate (Ritalin) and Pipradrol (Meratran)

1959 • 6 citations

Neurochemical Aspects of Behavior

1974 • 6 citations

Some Effects of Subcortical Stimulation on the Bar Press Response

1960 • 5 citations

Model systems in biological psychiatry

1975 • 5 citations

Differential Responses to an Anticholinergic Psychotomimetic (Ditran) in a Mixed Psychiatric Population

1966 • 5 citations

Electroencephalographic Findings in Treatment-Seeking Homosexuals Compared with Heterosexuals: a Controlled Study

1975 • 3 citations

Introduction to Pharmacology

1970 • 3 citations

L'E.E.G. dans les intoxations par les inhibiteurs de la cholinestérase (insecticides organo-phosphorés)

1975 • 3 citations

Influence of atropine and carbachol on the fluorescence of catecholaminergic structures in selected areas of the rat brain.

1976 • 1 citations