The Role of Fructose 2,6-Bisphosphate in the Regulation of Carbohydrate Metabolism

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

A Kinetic Study of Pyrophosphate: Fructose‐6‐Phosphate Phosphotransferase from Potato Tubers

1982 • 651 citations

Fructose 2,6-bisphosphate 2 years after its discovery

1982 • 428 citations

Futile Cycles in the Metabolism of Glucose

1976 • 322 citations

Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase

1980 • 309 citations

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate.

1981 • 257 citations

The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver

1972 • 250 citations

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate.

1981 • 239 citations

Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors.

1981 • 237 citations

Effects of ischaemia on content of metabolites in rat liver and kidney in vivo

1970 • 234 citations

Metabolic Interconversion of Enzymes

1972 • 228 citations

Control of Glycolysis and Gluconeogenesis in Liver and Kidney Cortex

1967 • 223 citations

Control of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase

1980 • 213 citations

Fructose 2,6-bisphosphate. A new activator of phosphofructokinase.

1981 • 207 citations

The effect of natural and synthetic D-fructose 2,6-bisphosphate on the regulatory kinetic properties of liver and muscle phosphofructokinases.

1981 • 195 citations

Regulation of Fructose‐Bisphosphatase Activity

1983 • 169 citations

Regulation of rat liver fructose 2,6-bisphosphatase.

1982 • 163 citations

Mechanism of Action of Fructose 1,6‐Bisphosphatase

1982 • 156 citations

The effect of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liver

1968 • 146 citations

Fructose‐2,6‐bisphosphatase from Rat Liver

1982 • 146 citations

Inactivation of phosphofructokinase by glucagon in rat hepatocytes.

1979 • 135 citations

Mechanism for the differential effects of high carbohydrate diets on lipogenesis in rat liver

1967 • 132 citations

Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs.

1982 • 131 citations

Glucagon and the Ca2+-linked hormones angiotensin II, norepinephrine, and vasopressin stimulate the phosphorylation of distinct substrates in intact hepatocytes.

1982 • 126 citations

The Role of Futile Cycles in the Regulation of Carbohydrate Metabolism in the Liver

1981 • 124 citations

D-Fructose 2,6-bisphosphate: A naturally occurring activator for inorganic pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase in plants

1981 • 124 citations

Hormone-stimulated phosphorylation of liver phosphofructokinase in vivo.

1979 • 119 citations

Phosphofructokinase 2 the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP

1981 • 116 citations

Fructose-2,6-P2, chemistry and biological function

1982 • 115 citations

Metabolic Interconversion of Enzymes 1980

1981 • 109 citations

Fructose 2,6-bisphosphate: A mediator of hormone action at the fructose 6-phosphate/fructose 1,6-bisphosphate substrate cycle

1982 • 105 citations

In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase.

1977 • 98 citations

An activation factor of liver phosphofructokinase.

1980 • 97 citations

Regulation of 6-phosphofructo-2-kinase activity by cyclic AMP-dependent phosphorylation.

1982 • 95 citations

Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid

1980 • 95 citations

Formation of Fructose 2,6‐Bisphosphate from Fructose 1,6‐Bisphosphate by Intramolecular Cyclisation followed by Alkaline Hydrolysis

1981 • 92 citations

Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver.

1981 • 91 citations

Regulation of fructose-6-phosphate 2-kinase by phosphorylation and dephosphorylation: possible mechanism for coordinated control of glycolysis and glycogenolysis.

1982 • 91 citations

The role of fructose 2,6-bisphosphate in regulation of fructose-1,6-bisphosphatase.

1981 • 90 citations

Study of the fructose 6-phosphate/fructose 1,6-bi-phosphate cycle in the liver in vivo

1980 • 82 citations

A novel enzyme catalyzes the synthesis of activation factor from ATP and D-fructose-6-P.

1981 • 80 citations

Properties of phospho and dephospho forms of muscle phosphofructokinase.

1982 • 78 citations

6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase from rat liver.

1983 • 78 citations

Changes in the concentration of activation factor for phosphofructokinase in hepatocytes in response to glucose and glucagon

1980 • 77 citations

The action of insulin on hepatic fructose 2,6-bisphosphate metabolism.

1983 • 77 citations

The structure of “activation factor” for phosphofructokinase.

1981 • 76 citations

Cyclic AMP-dependent phosphorylation of rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase

1982 • 75 citations

Enzymic determination of inorganic phosphate in the presence of creatine phosphate

1972 • 75 citations

Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes

1979 • 73 citations

Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate

1981 • 73 citations

The stimulation of yeast phosphofructokinase by fructose 2,6‐bisphosphate

1982 • 72 citations

Stereochemical courses of nucleotidyltransferase and phosphotransferase action. Uridine diphosphate glucose pyrophosphorylase, galactose-1-phosphate uridylyltransferase, adenylate kinase, and nucleoside diphosphate kinase

1979 • 72 citations

Fructose 2,6-bisphosphate in yeast

1981 • 71 citations

Role of fructose 2,6-bisphosphate in the stimulation of glycolysis by anoxia in isolated hepatocytes

1982 • 70 citations

Effect of Diabetes, Insulin, Starvation, and Refeeding on the Level of Rat Hepatic Fructose 2,6-Bisphosphate

1981 • 68 citations

Fructose diphosphatase from rabbit liver. X. Isolation and kinetic properties of the enzyme-adenosine monophosphate complex

1968 • 68 citations

The purification of fructose 1,6-diphosphatase from ox liver and its activation by ethylenediaminetetra-acetate

1975 • 68 citations

Effects of hormones and of ethanol on the fructose 6-P-fructose 1,6-P2 futile cycle during gluconeogenesis in the liver

1976 • 67 citations

Binding of adenosine 5'-monophosphate and substrate by rabbit liver fructose 1,6-diphosphatase

1969 • 65 citations

The interaction of fructose 2,6-bisphosphate and AMP with rat hepatic fructose 1,6-bisphosphatase.

1983 • 65 citations

Regulation of phosphofructokinase by a new mechanism. An activation factor binding to phosphorylated enzyme.

1980 • 64 citations

Regulation of fructose 2,6-P2 concentration in isolated hepatocytes

1981 • 63 citations

Studies on the phosphorylation of muscle phosphofructokinase.

1981 • 60 citations

Phosphorylation of rat hepatic fructose-1,6-bisphosphatase and pyruvate kinase.

1980 • 59 citations

Mechanism of action of glucagon on hepatocyte phosphofructokinase activity.

1980 • 56 citations

Regulation of the phosphorylation and activity of 6-phosphofructo 1-kinase in isolated hepatocytes by alpha-glycerolphosphate and fructose 2,6-bisphosphate.

1982 • 55 citations

Similarity of activation of yeast phosphofructokinase by AMP and fructose-2,6-bisphosphate

1983 • 50 citations

Studies on the mechanism of interaction of fructose 2,6-bisphosphate with fructose-1,6-bisphosphatase.

1982 • 49 citations

Rat liver phosphofructokinase: kinetic and physiological ramifications of the aggregation behavior

1980 • 49 citations

Evidence for a new activator of rat liver phosphofructokinase

1981 • 49 citations

Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: A unique bifunctional enzyme

1983 • 46 citations

An enzyme that catalyzes hydrolysis of fructose-2,6-bisphosphate

1982 • 45 citations

Phosphorylation of muscle phosphofructokinase by the catalytic subunit of cyclic AMP-dependent protein kinase

1978 • 41 citations

On the mechanism of inhibition of fructose 1,6-bisphosphatase by fructose 2,6-bisphosphate

1982 • 39 citations

Fructose-bisphosphatase as a substrate of cyclic AMP-dependent protein kinase.

1981 • 38 citations

Reciprocal changes in fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase activity in response to glucagon and epinephrine

1982 • 37 citations

Regulation of rat liver phosphofructokinase by glucagon-induced phosphorylation

1980 • 35 citations

Hormonal regulation of fructose-6-P-2-kinase and fructose-2,6-P2 by two mechanisms.

1982 • 34 citations

Nucleoside diphosphokinase from beef heart cytosol. II. Characterization of the phosphorylated intermediate

1972 • 33 citations

The effect of fructose 2,6-bisphosphate on the reverse reaction kinetics of fructose 1,6-bisphosphatase from bovine liver

1982 • 33 citations

Covalent Catalysis by Enzymes

1982 • 31 citations

The stimulation of phosphofructokinase from human erythrocytes by fructose 2,6‐bisphosphate

1982 • 31 citations

Glucagon stimulation of fructose 1,6-bisphosphatase phosphorylation in rat hepatocytes

1981 • 31 citations

Specific activation by fructose 2,6-bisphosphate and inhibition by P-enolpyruvate of ascites tumor phosphofructokinase

1982 • 30 citations

The effect of insulin and glucose on fructose-2,6-P2 in hepatocytes

1982 • 27 citations

Studies on the in vitro phosphorylation of 6-phosphofructo-1-kinase from rat liver

1982 • 27 citations

Structure and Configuration of Fructose 2,6‐Bisphosphate by ³¹P and ¹³C Nuclear Magnetic Resonance

1981 • 27 citations

Glucose-Induced Accumulation of Fructose-2,6-Bisphosphate in Pancreatic Islets

1982 • 26 citations

Is the glucose‐induced stimulation of glycolysis in pancreatic islets attributable to activation of phosphofructokinase by fructose 2,6‐bisphosphate?

1981 • 25 citations

Fructose 1,6-bisphosphatase in rat liver cytosol: Activation after glucagon treatment in vivo and inhibition by fructose 2,6-bisphosphate in vitro

1981 • 24 citations

Covalent Catalysis by Enzymes

2011 • 21 citations

The kinetics of unphosphorylated, phosphorylated and proteolytically modified fructose bisphosphatase from rat liver

1981 • 20 citations

Uridine diphosphate glucose breakdown is mediated by a unique enzyme activated by fructose 2,6-bisphosphate in Solanum tuberosum

1983 • 20 citations

Inactivation of liver phosphofructokinase by phosphofructokinase phosphatase or by low pH is inhibited by fructose 2,6‐bisphosphate

1981 • 19 citations

Regulation of hepatic altro heptulose 1,7‐bisphosphate levels and control of flux through the pentose pathway by fructose 2,6‐bisphosphate

1982 • 17 citations

Identification of the phosphorylated sites of phosphofructokinase from skeletal muscle after in vivo and in vitro phosphorylation

1979 • 17 citations

Reciprocal regulation of fructose 1,6-bisphosphatase and phosphofructokinase by fructose 2,6-bisphosphate in swine kidney

1983 • 14 citations

Increased concentration of fructose 2,6‐bisphosphate in livers of genetically obese mice

1982 • 13 citations

Fructose 2,6-bisphosphate levels are elevated in livers of genetically obese mice

1982 • 11 citations

Fructose-2,6-bisphosphate increases the binding affinity of yeast phosphofructokinase to AMP

1982 • 11 citations

Rat and rabbit liver mRNAs code for fructose 1,6-bisphosphatases that differ in molecular weight

1982 • 8 citations