Fructose 2,6-bisphosphate 2 years after its discovery

Evolution and Tinkering

1977 • 2,509 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

Phosphofructokinase and the Pasteur effect

1962 • 517 citations

Adenosine 3‘,5‘-Phosphate in Escherichia coli

1965 • 469 citations

The control of glycogen metabolism in the liver

1970 • 414 citations

Futile Cycles in the Metabolism of Glucose

1976 • 322 citations

Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase

1980 • 309 citations

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate.

1981 • 257 citations

Pathway of Succinate and Propionate Formation in Bacteroides fragilis

1978 • 246 citations

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate.

1981 • 239 citations

Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors.

1981 • 237 citations

Control of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase

1980 • 213 citations

Fructose 2,6-bisphosphate. A new activator of phosphofructokinase.

1981 • 207 citations

The Structures and Related Functions of Phosphorylase a

1980 • 197 citations

Studies on the inhibition of hepatic lipogenesis by N6,O2′-dibutyryl adenosine 3′,5′-monophosphate

1975 • 196 citations

The effect of natural and synthetic D-fructose 2,6-bisphosphate on the regulatory kinetic properties of liver and muscle phosphofructokinases.

1981 • 195 citations

Physiological Effects of Seven Different Blocks in Glycolysis in Saccharomyces cerevisiae

1979 • 171 citations

The Role of the Liver in the Homeostasis of Blood Glucose

1976 • 163 citations

Pyrophosphate:d-Fructose 6-Phosphate 1-Phosphotransferase

1974 • 162 citations

Turnover of Yeast Fructose-Bisphosphatase in Different Metabolic Conditions

1980 • 147 citations

Fructose‐2,6‐bisphosphatase from Rat Liver

1982 • 146 citations

End-product inhibition of yeast phosphofructokinase by ATP

1963 • 145 citations

Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation

1981 • 144 citations

Pyrophosphate-dependent 6-phosphofructokinase, a new glycolytic enzyme in pineapple leaves

1979 • 138 citations

Inactivation of phosphofructokinase by glucagon in rat hepatocytes.

1979 • 135 citations

Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii.

1975 • 131 citations

Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs.

1982 • 131 citations

The Role of Futile Cycles in the Regulation of Carbohydrate Metabolism in the Liver

1981 • 124 citations

D-Fructose 2,6-bisphosphate: A naturally occurring activator for inorganic pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase in plants

1981 • 124 citations

The Stimulation of Glycogen Synthesis and of Glycogen Synthetase in the Liver by the Administration of Glucose

1967 • 122 citations

Hormone-stimulated phosphorylation of liver phosphofructokinase in vivo.

1979 • 119 citations

Phosphofructokinase 2 the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP

1981 • 116 citations

Metabolic Interconversion of Enzymes 1980

1981 • 109 citations

An activation factor of liver phosphofructokinase.

1980 • 97 citations

Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid

1980 • 95 citations

Formation of Fructose 2,6‐Bisphosphate from Fructose 1,6‐Bisphosphate by Intramolecular Cyclisation followed by Alkaline Hydrolysis

1981 • 92 citations

The role of fructose 2,6-bisphosphate in regulation of fructose-1,6-bisphosphatase.

1981 • 90 citations

On the use of [3H, 14C] labelled glucose in the study of the so-called “Futile cycles” in liver and muscle

1974 • 85 citations

Study of the fructose 6-phosphate/fructose 1,6-bi-phosphate cycle in the liver in vivo

1980 • 82 citations

A novel enzyme catalyzes the synthesis of activation factor from ATP and D-fructose-6-P.

1981 • 80 citations

Changes in the concentration of activation factor for phosphofructokinase in hepatocytes in response to glucose and glucagon

1980 • 77 citations

The structure of “activation factor” for phosphofructokinase.

1981 • 76 citations

Rat Liver Phosphofructokinase

1974 • 75 citations

Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes

1979 • 73 citations

Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate

1981 • 73 citations

Fructose 2,6-bisphosphate in yeast

1981 • 71 citations

Utile and futile cycles in the liver

1974 • 68 citations

Regulation of phosphofructokinase by a new mechanism. An activation factor binding to phosphorylated enzyme.

1980 • 64 citations

Regulation of fructose 2,6-P2 concentration in isolated hepatocytes

1981 • 63 citations

Pathways of d-fructose and d-glucose catabolism in marine species of Alcaligenes, Pseudomonas marina, and Alteromonas communis

1977 • 62 citations

Stimulation of yeast phosphofructokinase activity by Fructose 2,6-bisphosphate

1981 • 57 citations

Mechanism of action of glucagon on hepatocyte phosphofructokinase activity.

1980 • 56 citations

Inorganic pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase in mung beans and its activation by D-fructose 1,6-bisphosphate and D-glucose 1,6-bisphosphate

1981 • 51 citations

Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation.

1979 • 47 citations

Stimulation of glycolysis and accumulation of a stimulator of phosphofructokinase in hepatocytes incubated with vasopressin

1981 • 43 citations

SYNTHESIS OF <scp>d</scp>-FRUCTOPYRANOSE 2-PHOSPHATE AND <scp>d</scp>-FRUCTOFURANOSE 2-PHOSPHATE

1963 • 40 citations

Regulation of rat liver phosphofructokinase by glucagon-induced phosphorylation

1980 • 35 citations

Inactivation of Gluconegenic Enzymes in Glycolytic Mutants of Saccharomyces cervisiae

1979 • 35 citations

Covalent Modification of Phosphofructokinase by Phosphorylation—Dephosphorylation* *Dedicated to Prof. Dr. Helmut Holzer, Biochemisches Institut der Universität Freiburg/Brg. on the occasion of his 60th birthday.

1981 • 29 citations

Structure and Configuration of Fructose 2,6‐Bisphosphate by ³¹P and ¹³C Nuclear Magnetic Resonance

1981 • 27 citations

Glucose-Induced Accumulation of Fructose-2,6-Bisphosphate in Pancreatic Islets

1982 • 26 citations

Is the glucose‐induced stimulation of glycolysis in pancreatic islets attributable to activation of phosphofructokinase by fructose 2,6‐bisphosphate?

1981 • 25 citations

Fructose 1,6-bisphosphatase in rat liver cytosol: Activation after glucagon treatment in vivo and inhibition by fructose 2,6-bisphosphate in vitro

1981 • 24 citations

Tricarboxylic Acid Cycle Intermediates and the Control of Fatty Acid Synthesis and Ketogenesis

1981 • 20 citations

Inactivation of liver phosphofructokinase by phosphofructokinase phosphatase or by low pH is inhibited by fructose 2,6‐bisphosphate

1981 • 19 citations

The Fructose 6-Phosphate/Fructose 1,6-Bisphosphate Cycle

1981 • 11 citations

Presence of fructose‐6‐phosphate,2‐kinase in pancreatic islets

1981 • 11 citations