Fructose 2,6-bisphosphate: A mediator of hormone action at the fructose 6-phosphate/fructose 1,6-bisphosphate substrate cycle

The Regulation of Glycolysis and Gluconeogenesis in Animal Tissues

1968 • 635 citations

Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase

1980 • 309 citations

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate.

1981 • 239 citations

Control of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase

1980 • 213 citations

Fructose 2,6-bisphosphate. A new activator of phosphofructokinase.

1981 • 207 citations

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1975 • 202 citations

Studies on the inhibition of hepatic lipogenesis by N6,O2′-dibutyryl adenosine 3′,5′-monophosphate

1975 • 196 citations

The effect of natural and synthetic D-fructose 2,6-bisphosphate on the regulatory kinetic properties of liver and muscle phosphofructokinases.

1981 • 195 citations

Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats☆

1974 • 163 citations

The Regulation of Liver Pyruvate Kinase by Phosphorylation—Dephosphorylation

1978 • 143 citations

Inhibition of Glucagon Effects in Perfused Rat Liver by (+)Decanoylcarnitine

1969 • 140 citations

Inactivation of phosphofructokinase by glucagon in rat hepatocytes.

1979 • 135 citations

Rapid Reciprocal Changes in Rat Hepatic Glycolytic Enzyme and Fructose Diphosphatase Activities following Insulin and Glucagon Injection

1974 • 135 citations

The Fructose 1,6-Diphosphatase-Phosphofructokinase Substrate Cycle

1974 • 121 citations

Hormone-stimulated phosphorylation of liver phosphofructokinase in vivo.

1979 • 119 citations

Phosphofructokinase 2 the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP

1981 • 116 citations

Hormonal control of [14C]glucose synthesis from [U-14C]dihydroxyacetone and glycerol in isolated rat hepatocytes

1976 • 108 citations

The Regulation of Pyruvate Kinase

1971 • 105 citations

Modulation of the phosphorylation state of rat liver pyruvate kinase by allosteric effectors and insulin.

1979 • 101 citations

Activation and inactivation of rat liver phosphofructokinase by phosphorylation—dephosphorylation

1975 • 98 citations

Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid

1980 • 95 citations

Studies on the phosphorylation and dephosphorylation of L-type pyruvate kinase by the catalytic subunit of cyclic AMP-dependent protein kinase.

1980 • 92 citations

Formation of Fructose 2,6‐Bisphosphate from Fructose 1,6‐Bisphosphate by Intramolecular Cyclisation followed by Alkaline Hydrolysis

1981 • 92 citations

Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver.

1981 • 91 citations

On the use of [3H, 14C] labelled glucose in the study of the so-called “Futile cycles” in liver and muscle

1974 • 85 citations

Influence of Glucagon on the Metabolism of Xylitol and Dihydroxyacetone in the Isolated Perfused Rat Liver

1973 • 84 citations

Study of the fructose 6-phosphate/fructose 1,6-bi-phosphate cycle in the liver in vivo

1980 • 82 citations

A novel enzyme catalyzes the synthesis of activation factor from ATP and D-fructose-6-P.

1981 • 80 citations

Changes in the concentration of activation factor for phosphofructokinase in hepatocytes in response to glucose and glucagon

1980 • 77 citations

The structure of “activation factor” for phosphofructokinase.

1981 • 76 citations

Control of pyruvate kinase activity by glucagon in isolated hepatocytes

1976 • 75 citations

Isolation and characterization of muscle phosphofructokinases with varying degrees of phosphorylation.

1978 • 75 citations

Rapid reciprocal changes of rat hepatic glycolytic enzymes and fructose-1,6-diphosphatase following glucagon and insulin injection in vivo

1972 • 74 citations

Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes

1979 • 73 citations

Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate

1981 • 73 citations

Fructose diphosphatase from rabbit liver. X. Isolation and kinetic properties of the enzyme-adenosine monophosphate complex

1968 • 68 citations

The purification of fructose 1,6-diphosphatase from ox liver and its activation by ethylenediaminetetra-acetate

1975 • 68 citations

Effects of hormones and of ethanol on the fructose 6-P-fructose 1,6-P2 futile cycle during gluconeogenesis in the liver

1976 • 67 citations

Binding of adenosine 5'-monophosphate and substrate by rabbit liver fructose 1,6-diphosphatase

1969 • 65 citations

Regulation of phosphofructokinase by a new mechanism. An activation factor binding to phosphorylated enzyme.

1980 • 64 citations

Regulation of fructose 2,6-P2 concentration in isolated hepatocytes

1981 • 63 citations

Studies on the phosphorylation of muscle phosphofructokinase.

1981 • 60 citations

Phosphorylation of rat hepatic fructose-1,6-bisphosphatase and pyruvate kinase.

1980 • 59 citations

Studies on the cyclic 3':5'-AMP-stimulated pig liver protein kinase reaction with pyruvate kinase as substrate.

1977 • 57 citations

Evidence for a new activator of rat liver phosphofructokinase

1981 • 49 citations

Fructose Diphosphatase from Rabbit Liver. VII. Tyrosine Residues and Adenosine Monophosphate Inhibition^*

1966 • 47 citations

Purification and properties of liver fructose 1,6-bisphosphatase from C57BL/KsJ normal and diabetic mice.

1980 • 47 citations

Stimulation of glycolysis and accumulation of a stimulator of phosphofructokinase in hepatocytes incubated with vasopressin

1981 • 43 citations

Phosphorylation of muscle phosphofructokinase by the catalytic subunit of cyclic AMP-dependent protein kinase

1978 • 41 citations

SYNTHESIS OF <scp>d</scp>-FRUCTOPYRANOSE 2-PHOSPHATE AND <scp>d</scp>-FRUCTOFURANOSE 2-PHOSPHATE

1963 • 40 citations

Mechanism of action of fructose 1,6-diphosphatase. Inhibition by structural analogs of fructose 1,6-diphosphate

1971 • 36 citations

Regulation of rat liver phosphofructokinase by glucagon-induced phosphorylation

1980 • 35 citations

Glucagon stimulation of fructose 1,6-bisphosphatase phosphorylation in rat hepatocytes

1981 • 31 citations

Stimulation of Fructose 1,6-Diphosphatase by Sulfhydryl Reagents and Interaction between the Different Enzymic Sites in the Molecule

1969 • 30 citations

Anomeric Specificity of the Alkaline Form of Fructose 1,6-Diphosphatase from Rabbit Liver

1974 • 30 citations

Fructose 1,6-Diphosphatase from Rabbit Liver. VI. Functional Tyrosyl Residues in the Active Center^*

1966 • 27 citations

Structure and Configuration of Fructose 2,6‐Bisphosphate by ³¹P and ¹³C Nuclear Magnetic Resonance

1981 • 27 citations

Amino acid sequence at the phosphorylated site of rat liver fructose-1,6-diphosphatase and phosphorylation of a corresponding synthetic peptide

1979 • 25 citations

The binding of products, metal ion, and a substrate analog to rabbit liver fructose bisphosphatase

1978 • 24 citations

Fructose 1,6-bisphosphatase in rat liver cytosol: Activation after glucagon treatment in vivo and inhibition by fructose 2,6-bisphosphate in vitro

1981 • 24 citations

Mouse muscle phosphofructokinase is partially phosphorylated

1978 • 24 citations

On the mechanism of alkaline and neutral fructose 1,6-diphosphatase: Inhibition by substrate analogs at neutral pH

1972 • 23 citations

Computer Simulation of the Fructose Bisphosphatase/Phosphofructokinase Couple in Rat Liver

1979 • 22 citations

Control in vivo of rat liver phosphofructokinase by glucagon and nutritional changes

1980 • 20 citations

Effect of glucagon administration on mice liver fructose-1, 6-bisphosphatase

1978 • 19 citations

Inactivation of liver phosphofructokinase by phosphofructokinase phosphatase or by low pH is inhibited by fructose 2,6‐bisphosphate

1981 • 19 citations