HLA-DR4 (DRB1*0401) Transgenic Mice Expressing an Altered CD4-Binding Site: Specificity and Magnitude of DR4-Restricted T Cell Response

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

1996 • 192 citations

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

1985 • 191 citations

Gene organization of DC and DX subregions of the human major histocompatibility complex.

1985 • 146 citations

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1996 • 139 citations

The role of CD4 in T-cell activation: accessory molecule or co-receptor?

1989 • 134 citations

Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401.

1994 • 127 citations

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

1994 • 90 citations

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

1993 • 87 citations

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

1986 • 83 citations

Species-specific binding of CD4 to the beta 2 domain of major histocompatibility complex class II molecules.

1992 • 70 citations

Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis.

1994 • 65 citations

Transgenic HLA-DRα faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to Eα in Eα0 mutant mice

1989 • 64 citations

EXPRESSION AND FUNCTION OF HLA‐DQ8 (DQA1*0301/DQB1*0302) GENES IN TRANSGENIC MICE

1996 • 55 citations

Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules.

1988 • 51 citations

T‐Cell Receptor Repertoire Selection by Mouse Mammary Tumor Viruses and MHC Molecules

1993 • 48 citations

Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma.

1989 • 44 citations

Thymic deletion of V beta 11+, V beta 5+ T cells in H-2E negative, HLA-DQ beta+ single transgenic mice.

1991 • 36 citations

Structural analysis of anti-DR1 allorecognition by using DR1/H-2Ek hybrid molecules. Influence of the beta 2-domain correlates with CD4 dependence.

1991 • 21 citations

In vivo expression and function of hybrid Ia dimers (E alpha A beta) in recombinant and transgenic mice.

1989 • 17 citations

DETERMINATION OF TOLERANCE TO SELF Eα PEPTIDES BY CLONAL ELIMINATION OF H-2E REACTIVE T CELLS AND ANTIGEN PRESENTATION BY H-2A MOLECULES

1992 • 12 citations

Mouse mammary tumor virus-mediated T-cell receptor negative selection in HLA-DRA transgenic mice

1993 • 11 citations

Structural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses

1992 • 9 citations

Identification and characterization of new intra h 2 recombinants

1985 • 1 citations