p53 expression in colorectal adenomas.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

P53 expression in breast cancer

1988 • 612 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Localization of gene for human p53 tumour antigen to band 17p13

1986 • 498 citations

Overexpression and mutation of p53 in epithelial ovarian cancer.

1991 • 464 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

1986 • 371 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

p53 expression in colorectal tumors.

1991 • 243 citations

Frequency and structure of p53 rearrangements in human osteosarcoma.

1990 • 199 citations

Expression of the nuclear oncogene p53 in colon tumours

1989 • 173 citations

Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.

1990 • 165 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

Expression of p53 and 17p allelic loss in colorectal carcinoma.

1992 • 130 citations

Mutation of the p53 gene in human acute myelogenous leukemia

1991 • 128 citations

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

1985 • 117 citations

Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP.

1988 • 106 citations

Purification of Complexes of Nuclear Oncogene p53 with Rat and Escherichia coli Heat Shock Proteins: In Vitro Dissociation of hsc70 and dnaK from Murine p53 by ATP

1988 • 28 citations