Mitogenic function of human procathepsin D: the role of the propeptide

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Lysosomes in Biology and Pathology

1974 • 768 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.

1988 • 287 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Cathepsin D. Purification of isoenzymes from human and chicken liver

1970 • 273 citations

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

1993 • 269 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.

1993 • 161 citations

Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation

1992 • 160 citations

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.

1991 • 156 citations

Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.

1993 • 149 citations

Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts.

1993 • 144 citations

Intracellular Sorting and Processing of a Yeast Vacuolar Hydrolase: Proteinase A Propeptide Contains Vacuolar Targeting Information

1988 • 121 citations

Interactions of Cathepsin-D and Insulin-Like Growth Factor-II (IGF-II) on the IGF-II/Mannose-6-Phosphate Receptor in Human Breast CancerCells and Possible Consequences on Mitogenic Activity of IGF-II

1990 • 119 citations

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells

1987 • 118 citations

Molecular recognition and targeting of lysosomal proteins

1991 • 105 citations

Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays.

1992 • 93 citations

Biological and Clinical Significance of Cathepsin D in Breast Cancer

1992 • 88 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

The pH-dependent membrane association of procathepsin L is mediated by a 9-residue sequence within the propeptide.

1994 • 74 citations

Effect of human procathepsin D on proliferation of human cell lines

1994 • 57 citations

Mannose 6-phosphate-specific receptor is a transmembrane protein with a C-terminal extension oriented towards the cytosol

1985 • 49 citations

The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein.

1993 • 49 citations

Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.

1994 • 43 citations

Human breast milk contains procathepsin D--detection by specific antibodies.

1993 • 42 citations

Proenzyme Form of Cathepsin L Produced by Thymic Epithelial Cells Promotes Proliferation of Immature Thymocytes in the Presence of IL-1, IL-7, and Anti-CD3 Antibody

1993 • 25 citations

Human cathepsin D precursor is associated with a 60 kDa glycosylated polypeptide

1992 • 22 citations

Isolation of a Membrane-Associated Cathepsin D-like Enzyme from the Model Antigen Presenting Cell, A20, and Its Ability to Generate Antigenic Fragments from a Protein Antigen in a Cell-Free System

1993 • 15 citations