Chronic Lymphocytic Leukemia B Cells Can Express CD40 Ligand and Demonstrate T-Cell Type Costimulatory Capacity

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

Chronic Lymphocytic Leukemia

1995 • 799 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.

1996 • 516 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas

1995 • 462 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.

1996 • 360 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation

1995 • 252 citations

Acquired CD40-ligand deficiency in chronic lymphocytic leukemia

1997 • 206 citations

The CD40 ligand expressed by human B cells costimulates B cell responses.

1995 • 200 citations

Advances in the biology and treatment of B-cell chronic lymphocytic leukemia

1995 • 198 citations

T Cell Helper Defect in Patients with Chronic Lymphocytic Leukemia

1979 • 197 citations

Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases

1993 • 183 citations

Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.

1978 • 173 citations

T-Cell chronic lymphocytic leukemia

1982 • 170 citations

Abnormal T-cell subpopulation function in CLL: excessive suppressor (T gamma) and deficient helper (T mu) activity with respect to B-cell proliferation

1981 • 168 citations

CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease.

1995 • 156 citations

Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells

1995 • 155 citations

Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases

1993 • 151 citations

Human CD40‐ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production

1993 • 143 citations

Serum immunoglobulins in B-chronic lymphocytic leukemia.Natural history and prognostic significance

1988 • 143 citations

Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).

1987 • 141 citations

Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B- lineage non-Hodgkin's lymphoma cells

1990 • 129 citations

A One-Step Procedure for Biotinylation and Chemical Cross-Linking of Lymphocyte Surface and Intracellular Membrane-Associated Molecules

1995 • 126 citations

Human B cell precursors proliferate and express CD23 after CD40 ligation.

1993 • 123 citations

T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.

1994 • 117 citations

Human Native Soluble CD40L Is a Biologically Active Trimer, Processed Inside Microsomes

1996 • 117 citations

Differentiation Capacity and Other Properties of the Leukemic Cells of Chronic Lymphocytic Leukemia*

1979 • 102 citations

Clinical staging and immunological findings in chronic lymphocytic leukemia

1979 • 93 citations

Adenovirus vector infection of chronic lymphocytic leukemia B cells

1996 • 91 citations

B lymphocytes from patients with chronic lymphoproliferative disorders are equipped with different costimulatory molecules.

1997 • 91 citations

5th International Workshop on Chronic Lymphocytic Leukemia

1992 • 77 citations

HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

1997 • 61 citations

The CD5/CD72 receptor system is coexpressed with several functionally relevant counterstructures on human B cells and delivers a critical signaling activity.

1996 • 56 citations

In vitro activation of leukaemic B cells by interleukin-4 and antibodies to CD40.

1993 • 51 citations

A human CD4- T cell leukemia subclone with contact-dependent helper function.

1991 • 50 citations

Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification

1996 • 42 citations

Defective interleukin-2 production and responsiveness by T cells in patients with chronic lymphocytic leukemia of B cell variety

1986 • 34 citations

Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes.

1982 • 30 citations

Isolation of cDNAS encoding T-BAM, a surface glycoprotein on CD4+ T cells mediating contact-dependent helper function for B cells: Identity with the CD40-ligand

1994 • 29 citations

PHA-induced soluble factor(s) can activate B-cells from patients with chronic lymphatic leukaemia.

1979 • 22 citations

Abnormal T cell function in early‐stage chronic lymphocytic leukemia (CLL) patients

1986 • 20 citations

Listeria monocytogenes osteomyelitis complicating leukemia: report and literature review of Listeria osteoarticular infections.

1990 • 20 citations

Phenotypic and functional characterization of T-BAM (CD40 ligand)+ T- cell non-Hodgkin's lymphoma

1994 • 15 citations

Bone marrow histopathologic patterns and immunologic findings in B-chronic lymphocytic leukemia

1984 • 15 citations

Update of CD antigens, 1996.

1997 • 10 citations

Study of CD40 ligand expression in B-cell chronic lymphocytic leukemia.

1995 • 9 citations

Chronic lymphocytic leukemia cells induce non-T cells to produce IgE in the presence of interleukin-4

1993 • 4 citations