“Wages of Fear”: transient threefold decrease in intracellular ATP level imposes apoptosis

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Physiological concentrations of purines and pyrimidines

1994 • 1,722 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

2001 • 1,025 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Bcl-2-family proteins and the role of mitochondria in apoptosis

2003 • 611 citations

Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle

2001 • 387 citations

Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide‐producing mitochondria and cell

1996 • 376 citations

Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

2003 • 337 citations

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

2001 • 320 citations

Ratio‐fluorescence microscopy of lipid oxidation in living cells using C11‐BODIPY^581/591

1999 • 303 citations

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

1998 • 294 citations

mTOR integrates amino acid- and energy-sensing pathways

2003 • 268 citations

Programmed Death Phenomena: From Organelle to Organism

2002 • 167 citations

Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis

2002 • 160 citations

Anti-apoptotic Effect of cGMP in Cultured Astrocytes

2001 • 147 citations

Mitochondria hyperpolarization is an early event in oxidized low‐density lipoprotein‐induced apoptosis in Caco‐2 intestinal cells

2002 • 114 citations

Mitochondria in the Programmed Death Phenomena; A Principle of Biology: “It Is Better to Die than to be Wrong”

2000 • 112 citations

Suppression of Stress Kinase JNK Is Involved in HSP72-mediated Protection of Myogenic Cells from Transient Energy Deprivation

2000 • 107 citations

Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism

2003 • 97 citations

Coenzyme Q blocks biochemical but not receptor‐mediated apoptosis by increasing mitochondrial antioxidant protection

2001 • 84 citations

Regulation of Necrosis of H9c2 Myogenic Cells upon Transient Energy Deprivation

2003 • 67 citations

Stoichiometry, Free Energy, and Kinetic Aspects of Cytochromec: Apaf-1 Binding in Apoptosis

1999 • 46 citations

Effects of the inhibitors of dynamics of cytoskeletal structures on the development of apoptosis induced by the tumor necrosis factor.

2002 • 23 citations

Respiration and mitochondrial membrane potential are not required for apoptosis and anti-apoptotic action of Bcl-2 in HeLa cells.

2002 • 15 citations