Consequences of HMG-Domain Protein Binding to Cisplatin-Modified DNA

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Male development of chromosomally female mice transgenic for Sry

1991 • 2,157 citations

The locus of sequence-directed and protein-induced DNA bending

1984 • 1,453 citations

HMG domain proteins: architectural elements in the assembly of nucleoprotein structures

1994 • 813 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins

1990 • 656 citations

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

1991 • 627 citations

Specific Binding of Chromosomal Protein HMG1 to DNA Damaged by the Anticancer Drug Cisplatin

1992 • 492 citations

Structural features of the HMG chromosomal proteins and their genes

1990 • 474 citations

DNA flexibility studied by covalent closure of short fragments into circles.

1981 • 456 citations

SRY, like HMG1, recognizes sharp angles in DNA.

1992 • 439 citations

Xeroderma Pigmentosum Group E Cells Lack a Nuclear Factor That Binds to Damaged DNA

1988 • 417 citations

Structure of the HMG box motif in the B-domain of HMG1.

1993 • 403 citations

HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

1994 • 343 citations

Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.

1993 • 340 citations

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

1993 • 327 citations

DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein.

1992 • 322 citations

DNA unwinding produced by site-specific intrastrand crosslinks of the antitumor drug cis-diamminedichloroplatinum(II)

1991 • 289 citations

Solution structure of a DNA-binding domain from HMG1

1993 • 275 citations

An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.

1992 • 260 citations

A signature for the HMG‐1 box DNA‐binding proteins

1993 • 258 citations

Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.

1992 • 246 citations

Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.

1992 • 218 citations

The DNA-Bending Protein HMG-1 Enhances Progesterone Receptor Binding to Its Target DNA Sequences

1994 • 200 citations

In vivo effects of cis- and trans-diamminedichloroplatinum(II) on SV40 chromosomes: differential repair, DNA-protein crosslinking, and inhibition of replication

1985 • 199 citations

High-mobility-group 1 protein mediates DNA bending as determined by ring closures.

1993 • 193 citations

Ixr1, a Yeast Protein That Binds to Platinated DNA and Confers Sensitivity to Cisplatin

1993 • 177 citations

DNA binding properties of an HMG1-related protein from yeast mitochondria.

1992 • 175 citations

LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites.

1993 • 161 citations

SRY recognizes conserved DNA sites in sex-specific promoters.

1993 • 151 citations

Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1 and 2.

1992 • 150 citations

Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor).

1994 • 149 citations

Bending studies of DNA site-specifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-[Pt(NH3) 2 (N3-cytosine) Cl]+

1990 • 145 citations

DNA looping by the HMG-box domains of HMG1 and modulation of DNA binding by the acidic C-terminal domain

1994 • 139 citations

HMG-D, the Drosophila melanogaster homologue of HMG 1 protein, is associated with early embryonic chromatin in the absence of histone H1.

1994 • 138 citations

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity.

1993 • 137 citations

Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin

1990 • 133 citations

High mobility group proteins 1 and 2 function as general class II transcription factors

1990 • 129 citations

Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines.

1993 • 129 citations

Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors.

1994 • 116 citations

An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

1992 • 113 citations

The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences.

1994 • 108 citations

The specific interactions of HMG 1 and 2 with negatively supercoiled DNA are modulated by their acidic C-terminal domains and involve cysteine residues in their HMG 1/2 boxes

1993 • 107 citations

Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)

1989 • 102 citations

Functional differences between the two splice variants of the nucleolar transcription factor UBF: the second HMG box determines specificity of DNA binding and transcriptional activity.

1994 • 98 citations

HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes.

1991 • 96 citations

Mouse rRNA gene transcription factor mUBF requires both HMG-box1 and an acidic tail for nucleolar accumulation: molecular analysis of the nucleolar targeting mechanism.

1992 • 89 citations

High mobility group proteins 1 and 2 stimulate binding of a specific transcription factor to the adenovirus major late promoter

1988 • 89 citations

HMG Domain Proteins Induce Sharp Bends in Cisplatin-Modified DNA

1994 • 81 citations

The HMG box-containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I.

1994 • 70 citations

Effects of high mobility group proteins 1 and 2 on initiation and elongation of specific transcription by RNA polymerase IIin vitro

1988 • 69 citations

High mobility group protein 1 preferentially conserves torsion in negatively supercoiled DNA

1989 • 61 citations

Characterization of high mobility group protein binding to cisplatin-damaged DNA

1992 • 60 citations

Specific interaction between H1 histone and high mobility protein HMG1

1994 • 52 citations

Biological processing of DNA modified by platinum compounds

1990 • 51 citations

Harnessing the writhe: a role for DNA chaperonesin nucleoprotein- complex formation

1994 • 51 citations

Assessment of the Transcriptional Activation Potential of the HMG Chromosomal Proteins

1991 • 46 citations

A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus.

1993 • 37 citations

Isolation and characterization of cDNA clones encoding theDrosophilahomolog of the HMG-box SSRP family that recognizes specific DNA structures

1993 • 37 citations

The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.

1993 • 36 citations

Binding of cis- and trans-diamminedichloroplatinum(II) to deoxyribonucleic acid exposes nucleosides as measured immunochemically with anti-nucleoside antibodies

1986 • 35 citations

Cis-diamminedichloroplatinum(II) selectively cross-links high mobility group proteins 1 and 2 to DNA in micrococcal nuclease accessible regions of chromatin

1987 • 33 citations

Assessment of the transcriptional activation potential of the HMG chromosomal proteins.

1991 • 27 citations

Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly at physiological ionic strength

1989 • 25 citations

Cisplatin-DNA damage recognition proteins in human tumour extracts

1993 • 23 citations

cis-Diamminedichloroplatinum (II) modified chromatin and nucleosomal core particle

1991 • 21 citations

Localization of the binding region of high mobility group protein 2 to cisplatin-damaged DNA.

1993 • 17 citations

Rat and chick cDNA clones encoding HMG-like proteins

1993 • 12 citations

cis-Diamminedichloroplatinum (II) modified chromatin and nucleosomal core particle probed with DNase I

1991 • 10 citations

Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2)

1992 • 7 citations

Potential negative regulation of damage-recognition proteins in cisplatin-resistant HeLa cells in response to DNA damage

1991 • 7 citations