Iron Regulation of Transferrin Receptor mRNA Stability

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS

1987 • 1,305 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Iron transport and storage

1987 • 688 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

1986 • 684 citations

Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency

1985 • 645 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

The physiology of transferrin and transferrin receptors.

1987 • 586 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA

1987 • 547 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis

1985 • 469 citations

Ferritin: structure, biosynthesis, and role in iron metabolism.

1978 • 390 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

1987 • 365 citations

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

1988 • 363 citations

Expression of the c-myb proto-oncogene during cellular proliferation

1986 • 360 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Regulation of ferritin and transferrin receptor mRNAs.

1990 • 339 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA.

1989 • 334 citations

Novel mechanism for translational control in regulation of ferritin synthesis by iron.

1976 • 324 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Ferritin: Its Properties and Significance for Iron Metabolism.

1946 • 266 citations

Microbial Iron Metabolism

1974 • 250 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.

1989 • 245 citations

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.

1989 • 244 citations

Prediction of RNA secondary structure, including pseudoknotting, by computer simulation

1990 • 227 citations

Recent developments in the field of iron‐sulfur proteins

1990 • 223 citations

Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.

1987 • 220 citations

Posttranscriptional regulation of c-fos mRNA expression

1987 • 215 citations

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

1990 • 205 citations

A regulated RNA binding protein also possesses aconitase activity.

1991 • 204 citations

Multiple regulatory steps control histone mRNA concentrations

1988 • 199 citations

The structure of aconitase

1989 • 183 citations

Regulation of HeLa cell transferrin receptors.

1982 • 182 citations

Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells.

1987 • 165 citations

Regulation of Interaction of the Iron-Responsive Element Binding Protein with Iron-Responsive RNA Elements

1989 • 164 citations

Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells.

1984 • 145 citations

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.

1989 • 144 citations

Purification of a Specific Repressor of Ferritin mRNA Translation from Rabbit Liver

1989 • 138 citations

Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 • 131 citations

Regulation of transferrin receptor expression on human leukemic cells during proliferation and induction of differentiation. Effects of gallium and dimethylsulfoxide.

1983 • 130 citations

Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.

1991 • 127 citations

The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution

1990 • 125 citations

A model for the structure and functions of iron-responsive elements

1988 • 119 citations

Multiple determinants of eukaryotic mRNA stability.

1989 • 118 citations

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation

1990 • 114 citations

Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.

1985 • 113 citations

Determinants of the interaction between the iron-responsive element-binding protein and its binding site in rat L-ferritin mRNA.

1990 • 112 citations

Translational repression in eukaryotes: partial purification and characterization of a repressor of ferritin mRNA translation.

1988 • 109 citations

Inorganic biochemistry of iron metabolism

1992 • 108 citations

Properties of the exonuclease activity that degrades H4 histone mRNA.

1987 • 102 citations

Poly(A) Tail Shortening Is the Translation-Dependent Step in c-myc mRNA Degradation

1990 • 100 citations

Intracellular trafficking of proteins

1991 • 97 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.

1989 • 94 citations

Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.

1988 • 91 citations

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.

1988 • 87 citations

Coordinate Post-Transcriptional Regulation of Ferritin and Transferrin Receptor Expression: The Role of Regulated RNA-Protein Interaction

1990 • 86 citations

Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

1986 • 83 citations

Failure to release iron from transferrin in a Chinese hamster ovary cell mutant pleiotropically defective in endocytosis.

1984 • 80 citations

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA

1989 • 72 citations

Ribonucleotide Reductases

1990 • 71 citations

Iron and Oxygen: A Biologically Damaging Mixture

1989 • 69 citations

Influence of altered transcription on the translational control of human ferritin expression.

1987 • 64 citations

Transcriptional Inactivation of c-myc and the Transferrin Receptor in Dibutyryl Cyclic AMP-Treated HL-60 Cells

1987 • 54 citations

Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation.

1990 • 50 citations

Characterization of Rat Transferrin Receptor cDNA: The Regulation of Transferrin Receptor mRNA in Testes and in Sertoli Cells in Culture

1990 • 49 citations

Transferrin: Receptor-Mediated Endocytosis and Iron Delivery

1985 • 44 citations

Chicken transferrin receptor gene: conservation 3′ noncoding sequences and expression in erythroid cells

1989 • 31 citations

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.

1987 • 31 citations

The transferrin receptor: a key function in iron metabolism.

1989 • 21 citations

The secondary structure of the regulatory region of the transferrin receptor mRNA deduced by enzymatic cleavage.

1992 • 14 citations