Alterations of neurotransmitter-related gene expression in human and experimental portal-systemic encephalopathy.

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts.

1977 • 430 citations

Ammonia: Key factor in the pathogenesis of hepatic encephalopathy

1987 • 397 citations

Cerebral Ammonia Metabolism in Patients with Severe Liver Disease and Minimal Hepatic Encephalopathy

1991 • 328 citations

Brain α‐Ketoglutarate Dehydrogenase Complex: Kinetic Properties, Regional Distribution, and Effects of Inhibitors

1986 • 308 citations

Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms

1996 • 275 citations

Manganese intoxication and chronic liver failure

1994 • 239 citations

Role of liver in regulating distribution and excretion of manganese

1966 • 229 citations

Visualizing manganese in the primate basal ganglia with magnetic resonance imaging

1989 • 227 citations

Hyperintense basal ganglia on T1-weighted MR images in patients receiving parenteral nutrition.

1991 • 203 citations

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure

1997 • 184 citations

Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy

1995 • 182 citations

Pallidal hyperintensity on magnetic resonance imaging in cirrhotic patients: Clinical correlations

1992 • 153 citations

EXPERIMENTAL MANGANESE ENCEPHALOPATHY IN MONKEYS

1963 • 152 citations

Altered Cerebral Blood Flow and Glucose Metabolism in Patients with Liver Disease and Minimal Encephalopathy

1991 • 152 citations

Increased Densities of Peripheral–Type Benzodiazepine Receptors in Brain Autopsy Samples From Cirrhotic Patients With Hepatic Encephalopathy

1990 • 142 citations

The Astrocyte in Liver Disease

1981 • 140 citations

Selective Loss of N‐Methyl‐d‐Aspartate‐Sensitive l‐[³H]Glutamate Binding Sites in Rat Brain Following Portacaval Anastomosis

1990 • 116 citations

Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

1989 • 114 citations

Mitochondrial benzodiazepine receptors as potential modulators of intermediary metabolism

1986 • 113 citations

Pallidal lesions in patients with liver cirrhosis: clinical and MRI evaluation

1995 • 113 citations

Positron-emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy

1993 • 107 citations

Manganese, Copper, and Zinc Concentrations in Serum and Packed Blood Cells during Acute Hepatitis, Chronic Hepatitis, and Posthepatitic Cirrhosis

1974 • 106 citations

Selective loss of pallidal dopamine D2 receptor density in hepatic encephalopathy

1993 • 102 citations

Dystonia, hyperintense basal ganglia, and high whole blood manganese levels in Alagille's syndrome

1994 • 86 citations

Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis

1997 • 80 citations

Increased densities of binding sites for the ‘peripheral-type’ benzodiazepine receptor ligand [3H]PK 11195 in rat brain following portacaval anastomosis

1992 • 80 citations

Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy

1987 • 77 citations

Long-term hemodynamic effects of ketanserin, a 5-hydroxytryptamine blocker, in portal hypertensive patients

1989 • 77 citations

Increased Density of Catalytic Sites and Expression of Brain Monoamine Oxidase A in Humans with Hepatic Encephalopathy

1997 • 71 citations

Neurochemical and electrophysiological studies on the inhibitory effect of ammonium ions on synaptic transmission in slices of rat hippocampus: Evidence for a postsynaptic action

1990 • 70 citations

Ammonia-induced upregulation of peripheral-type benzodiazepine receptors in cultured astrocytes labeled with [3H]PK 11195

1994 • 67 citations

Increased activities of MAOA and MAOB in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

1993 • 65 citations

Chronic exposure of rat primary astrocyte cultures to manganese results in increased binding sites for the ‘peripheral-type’ benzodiazepine receptor ligand 3H-PK 11195

1999 • 64 citations

Portal-Systemic Encephalopathy: A Disorder of Neuron-Astrocytic Metabolic Trafficking

1993 • 62 citations

Neurophysiology of Ammonia Intoxication

1989 • 57 citations

Cerebral Phosphorus-31 magnetic resonance spectroscopy in patients with chronic hepatic encephalopathy

1994 • 55 citations

Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy

1991 • 52 citations

Cerebrospinal Fluid Lactate in Patients with Hepatic Encephalopathy

1987 • 46 citations

Increased expression of the peripheral-type benzodiazepine receptor-isoquinoline carboxamide binding protein mRNA in brain following portacaval anastomosis

1997 • 36 citations

Portacaval Shunting and Hyperammonemia Stimulate the Uptake of <scp>l</scp>‐[³H]Arginine but Not of <scp>l</scp>‐[³H]Nitroarginine into Rat Brain Synaptosomes

1997 • 36 citations

Alterations of [3H]8-OH-DPAT and [3H]ketanserin binding sites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

1994 • 36 citations

Increased Densities of Binding Sites for the Peripheral-Type Benzodiazepine Receptor Ligand [3H]PK 11195 in Congenital Ornithine Transcarbamylase-Deficient Sparse Fur Mouse

1993 • 36 citations

Local Cerebral Glucose Metabolism in Rats with Chronic Portacaval Shunts

1983 • 36 citations

CNS tryptamine metabolism in hepatic coma

1980 • 34 citations

Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis

1994 • 33 citations

Neuronal nitric oxide synthase and Hepatic Encephalopathy.

1998 • 30 citations

Portacaval anastomosis induces region-selective alterations of the endogenous opioid system in the rat brain

1996 • 25 citations

Brain β-endorphin concentrations in experimental chronic liver disease

1982 • 25 citations

Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues

1999 • 22 citations

Portacaval anastomosis results in more widespread alterations of cerebral metabolism in old versus young adult rats: implications for post-shunt encephalopathy.

1998 • 15 citations

Chronic hepatic encephlopathy studied by NMR spectroscopy and MRI in man

1991 • 11 citations

The Portacaval‐Shunted Rat: A New Model for the Study of the Mechanisms Controlling Voluntary Ethanol Consumption and Ethanol Preference?

1997 • 9 citations

Beta-Endorphin and Opiate Receptor Changes in Acute and Chronic Models of Hepatic Encephalopathy

1989 • 6 citations

Increased manganese (Mn2+) in blood and in pallidum of cirrhotic patients with hepatic encephalopathy: Factor responsible for magnetic resonance (MR) Signal hyperintensity?

1995 • 5 citations

Deleted Work

1955 • 0 citations