Ammonia: Key factor in the pathogenesis of hepatic encephalopathy

Handbook of clinical neurology

1975 • 1,642 citations

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts.

1977 • 430 citations

HYPERAMMONÆMIA, PLASMA AMINOACID IMBALANCE, AND BLOOD-BRAIN AMINOACID TRANSPORT: A UNIFIED THEORY OF PORTAL-SYSTEMIC ENCEPHALOPATHY

1979 • 413 citations

Episodic Stupor Associated with an Eck Fistula in the Human with Particular Reference to the Metabolism of Ammoniaxs12

1954 • 341 citations

The neurological disorder associated with liver disease.

1953 • 329 citations

Plasma and Brain Amino Acids in Fulminant Hepatic Failure and their Relationship to Hepatic Encephalopathy

1976 • 285 citations

Die Eck'sche Fistel zwischen der unteren Hohlvene und der Pfortader und ihre Folgen für den Organismus

1893 • 250 citations

Reversible Toxic Manifestations in Patients with Cirrhosis of the Liver Given Cation-Exchange Resins

1952 • 152 citations

BLOOD-AMMONIUM LEVELS IN LIVER DISEASE AND "HEPATIC COMA"

1955 • 119 citations

Ein Beitrag zur Klinik und pathologischen Anatomie der Westphal-Strümpellschen Pseudosklerose

1912 • 101 citations

Metabolic and Toxic Diseases of the Nervous System

1954 • 90 citations

Disinhibition in cat motor cortex by ammonia

1975 • 90 citations

Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy

1984 • 85 citations

Blood ammonia concentration in liver disease, and liver coma.

1954 • 82 citations

THE EFFECT OF PORTA‐CAVAL ANASTOMOSIS UPON THE ENERGY STATE AND UPON ACID‐BASE PARAMETERS OF THE RAT BRAIN

1974 • 68 citations

Regulation of glutaminase by exogenous glutamate, ammonia and 2-oxoglutarate in synaptosomal enriched preparation from rat brain

1982 • 65 citations

AMMONIUM ION INHIBITION OF EVOKED RELEASE OF ENDOGENOUS GLUTAMATE FROM HIPPOCAMPAL SLICES

1979 • 60 citations

BRAIN HISTOLOGY AND BEHAVIOR OF MICE INJECTED WITH UREASE

1974 • 57 citations

Glutamic acid and glutamine levels in serum and cerebrospinal fluid in hepatic encephalopathy

1984 • 50 citations

Alzheimer II Astrocytosis Following Methionine Sulfoximine

1975 • 46 citations

An Experimental Model for the Study of Hepatic Encephalopathy

1974 • 41 citations

Cerebral aminoacids in portal-systemic encephalopathy: Lack of evidence for altered ?-aminobutyric acid (GABA) function

1986 • 40 citations

Effects of ammonium chloride on synaptic transmission in the rat hippocampal slice

1985 • 38 citations

Pathophysiology of Hepatic Encephalopathy

1984 • 33 citations

Action of ammonium on a chloride pump

1974 • 32 citations

Über die Bedeutung der Eckschen Fistel für die normale und pathologische Physiologie der Leber

1920 • 16 citations

Advances in hepatic encephalopathy and urea cycle diseases

1985 • 16 citations

Region-Selective Glutamine Changes in the CNS in Relation to Function in Experimental Subacute Hepatic Encephalopathy

2015 • 9 citations

Glutamic acid abnormalities in the central nervous system in hepatic encophalopathy

1982 • 9 citations

Metabolic turnover in the reticular activating system in ammonia induced coma.

1981 • 4 citations