Neuronal nitric oxide synthase and Hepatic Encephalopathy.

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Nitric oxide synthases: which, where, how, and why?

1997 • 1,019 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Biochemistry and physiology of brain ammonia.

1987 • 829 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Nitric Oxide Synthase in Models of Focal Ischemia

1997 • 659 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

1996 • 576 citations

Nitric Oxide in the Nervous System

1995 • 503 citations

Role of NO Production in NMDA Receptor-Mediated Neurotransmitter Release in Cerebral Cortex

1994 • 476 citations

Nitric oxide-induced blockade of NMDA receptors

1992 • 455 citations

Ammonia: Key factor in the pathogenesis of hepatic encephalopathy

1987 • 397 citations

Modulation of In Vivo Striatal Transmitter Release by Nitric Oxide and Cyclic GMP

1994 • 367 citations

CAPON: A Protein Associated with Neuronal Nitric Oxide Synthase that Regulates Its Interactions with PSD95

1998 • 365 citations

Nitric Oxide in the Vasculature: Physiology and Pathophysiology

1997 • 348 citations

Endothelial Nitric-oxide Synthase

1996 • 322 citations

Excitatory Amino Acid Receptors Coupled to the Nitric Oxide/Cyclic GMP Pathway in Rat Cerebellum During Development

1991 • 224 citations

Selective inhibitors of neuronal nitric oxide synthase – is no NOS really good NOS for the nervous system?

1997 • 201 citations

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure

1997 • 184 citations

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure

1996 • 168 citations

Glutamine,myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: Implications for ammonia-induced brain edema

1996 • 167 citations

Subcellular Localization and Characterization of Neuronal Nitric Oxide Synthase

1994 • 148 citations

The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: Relation to energy metabolism and glutamatergic neurotransmission

1997 • 145 citations

The Release and Neosynthesis of Glutamic Acid Are Increased in Experimental Models of Hepatic Encephalopathy

1983 • 127 citations

Induced Nitric Oxide Synthesis Is Dependent on Induced Alternatively Spliced CAT-2 Encoding L-Arginine Transport in Brain Astrocytes

1996 • 118 citations

Natural Disruption of the Mouse Mast Cell Protease 7 Gene in the C57BL/6 Mouse

1996 • 116 citations

Selective Loss of N‐Methyl‐d‐Aspartate‐Sensitive l‐[³H]Glutamate Binding Sites in Rat Brain Following Portacaval Anastomosis

1990 • 116 citations

Metabolic Abnormalities and Grade of Encephalopathy in Acute Hepatic Failure

1994 • 114 citations

Cloning and Characterization of a Brain-specific Cationic Amino Acid Transporter

1997 • 114 citations

Current Theories on the Pathogenesis of Hepatic Encephalopathy

1994 • 110 citations

A New Member of the Cationic Amino Acid Transporter Family Is Preferentially Expressed in Adult Mouse Brain

1997 • 108 citations

Nitric oxide inhibits ³H‐glutamate transport in synaptosomes

1994 • 105 citations

Brain Ion and Amino Acid Contents During Edema Development in Hepatic Encephalopathy

1994 • 99 citations

Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors.

1993 • 85 citations

Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy

1984 • 85 citations

Transport of <scp>l</scp>‐[³H]Arginine in Cultured Neurons: Characteristics and Inhibition by Nitric Oxide Synthase Inhibitors

1993 • 84 citations

Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis

1997 • 80 citations

Increased Nitric Oxide Synthase Activities and <scp>l</scp>‐[³H]Arginine Uptake in Brain Following Portacaval Anastomosis

1995 • 77 citations

Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes

1995 • 77 citations

Hyperammonaemia causes many of the changes found after portacaval shunting

1990 • 75 citations

Brain cortical amino acids measured by intracerebral dialysis in portacaval shunted rats

1987 • 73 citations

Neurochemical and electrophysiological studies on the inhibitory effect of ammonium ions on synaptic transmission in slices of rat hippocampus: Evidence for a postsynaptic action

1990 • 70 citations

Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter: A comparison of two rodent models of fulminant liver failure

1992 • 70 citations

Roles of neuroactive amino acids in ammonia neurotoxicity.

1998 • 69 citations

Protective effect ofL-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat

1997 • 65 citations

Transport of L‐arginine in cultured glial cells

1994 • 62 citations

Selective Alterations of Extracellular Brain Amino Acids in Relation to Function in Experimental Portal‐Systemic Encephalopathy: Results of an In Vivo Microdialysis Study

1995 • 58 citations

Effect of Portacaval Anastomosis on Electrically Stimulated Release of Glutamate from Rat Hippocampal Slices

1991 • 55 citations

Pathologic concentrations of ammonium ions block l-glutamate uptake

1985 • 54 citations

Ammonia and manganese increase arginine uptake in cultured astrocytes.

1998 • 54 citations

Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat

1995 • 52 citations

Human Postsynaptic Density-95 (PSD95): Location of the Gene (DLG4) and Possible Function in Nonneural as Well as in Neural Tissues

1997 • 51 citations

Glutamatergic synaptic dysfunction in hyperammonemic syndromes

1992 • 50 citations

Na+-Independent Transport (Uniport) of Amino Acids and Glucose in Mammalian Cells

1994 • 46 citations

Alterations in Cortical [³H]Kainate and α‐[³H]Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Binding in a Spontaneous Canine Model of Chronic Hepatic Encephalopathy

1991 • 46 citations

Differential Effects on Portal and Effective Hepatic Blood Flow

1997 • 44 citations

Neocortical Dialysate Monoamines of Rats After Acute, Subacute, and Chronic Liver Shunt

1995 • 44 citations

Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure

1997 • 43 citations

[³H]L-N^G-Nitroarginine Binding after Transient Focal Ischemia and NMDA-Induced Excitotoxicity in Type I and Type III Nitric Oxide Synthase Null Mice

1997 • 43 citations

Portacaval Anastomosis Results in Altered Neuron‐Astrocytic Metabolic Trafficking of Amino Acids: Evidence from ¹³C‐NMR Studies

1996 • 41 citations

Characterization of Neuronal Amino Acid Transporters: Uptake of Nitric Oxide Synthase Inhibitors and Implication for Their Biological Effects

1995 • 40 citations

Cerebral aminoacids in portal-systemic encephalopathy: Lack of evidence for altered ?-aminobutyric acid (GABA) function

1986 • 40 citations

Cerebrospinal fluid amino acids in relation to neurological status in experimental portal-systemic encephalopathy

1991 • 39 citations

Substrate specificity of uptake of diamines in mouse brain slices

1974 • 38 citations

Characterization of the binding of [³H]‐<scp>l</scp>‐N^G‐nitro‐arginine in rat brain

1993 • 37 citations

Portacaval Shunting and Hyperammonemia Stimulate the Uptake of <scp>l</scp>‐[³H]Arginine but Not of <scp>l</scp>‐[³H]Nitroarginine into Rat Brain Synaptosomes

1997 • 36 citations

Activation of arginine metabolism to glutamate in rat brain synaptosomes in thioacetamide‐induced hepatic encephalopathy: An adaptative response?

1990 • 33 citations

Partial Portacaval Shunt for Variceal Hemorrhage

1998 • 31 citations

Characterization of <scp>l</scp>‐Arginine and Aminoguanidine Uptake into Isolated Rat Choroid Plexus: Differences in Uptake Mechanisms and Inhibition by Nitric Oxide Synthase Inhibitors

1995 • 22 citations

L-Ornithine vs. L-ornithine-L-aspartate as a treatment for hyperammonemia-induced encephalopathy in rats

1997 • 22 citations

Membrane Transport of Neuronal Nitric Oxide Synthase Substrate <scp>l</scp>‐Arginine Is Constitutively Expressed with CAT1 and 4F2hc, but Not CAT2 or rBAT

1998 • 20 citations

Stenosis of a portacaval anastomosis affects circadian locomotor activity in the rat: a multivariable analysis

1997 • 20 citations

Amino acids differentially inhibit the l-[3H]arginine transport and nitric oxide synthase in rat brain synaptosomes

1994 • 20 citations

<scp>l</scp>‐[³H]Nitroarginine and <scp>l</scp>‐[³H]Arginine Uptake into Rat Cerebellar Synaptosomes: Kinetics and Pharmacology

1996 • 19 citations

Arginine in thioacetamide-induced hepatogenic encephalopathy in rats: activation of enzymes of arginine metabolism to glutamate

1986 • 18 citations

Effect of Citalopram on Brain Serotonin Release in Experimental Hepatic Encephalopathy

1997 • 16 citations

Modulation of AMPA receptor subunits GluR1 and GluR2/3 in the rat cerebellum in an experimental hepatic encephalopathy model

1997 • 16 citations

Portacaval anastomosis results in more widespread alterations of cerebral metabolism in old versus young adult rats: implications for post-shunt encephalopathy.

1998 • 15 citations

Experimental, clinical, and metabolic results of side-to-side portacaval shunt for intractable cirrhotic ascites.

1997 • 14 citations

Kinetics, Pharmacology, and Autoradiographic Distribution of <scp>l</scp>‐[³H]Nitroarginine Binding Sites in Rat Cerebellum

1996 • 14 citations

Comparison of the metabolic disturbances caused by end-to-side and side-to-side portacaval shunts

1996 • 12 citations

Regional distribution of binding sites for the nitric oxide synthase inhibitorl-[3H]Nitroarginine in rat brain

1996 • 12 citations

Nitric oxide.

1994 • 11 citations

Hyperammonemia inhibits platelet aggregation in rats

1996 • 10 citations

Immediate and Long-Term Portal Hemodynamic Consequences of Small-Diameter H-Graft Portacaval Shunt

1998 • 9 citations

An enzymatic route to L-ornithine from L-arginine--activation and stabilization studies on L-arginase.

1991 • 6 citations