Insertional Mutagenesis in Mouse Mammary Tumorigenesis

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Peptide growth factors are multifunctional

1988 • 835 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

The new mouse genetics: Altering the genome by gene targeting

1989 • 608 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Molecular cloning of sequences from wingless , a segment polarity gene in Drosophila : the spatial distribution of a transcript in embryos

1987 • 437 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumors

1983 • 327 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Retinoic Acid-Induced Neural Differentiation of Embryonal Carcinoma Cells

1983 • 308 citations

The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements

1983 • 299 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene.

1989 • 284 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos

1987 • 261 citations

Complete nucleotide sequence of a milk-transmitted mouse mammary tumor virus: two frameshift suppression events are required for translation of gag and pol

1987 • 258 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact

1984 • 222 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Retinoic acid-induced neural differentiation of embryonal carcinoma cells.

1983 • 213 citations

Multiple functions of segment polarity genes in Drosophila

1987 • 212 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors

1987 • 203 citations

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

1988 • 194 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

1990 • 188 citations

The development of wingless, a homeotic mutation of Drosophila

1977 • 185 citations

Breast Cancer: Cellular and Molecular Biology

1988 • 182 citations

Amplification of the int-2 gene in primary human breast tumors.

1988 • 172 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors.

1989 • 160 citations

Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF

1989 • 154 citations

A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human.

1989 • 151 citations

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway

1987 • 141 citations

Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene

1983 • 140 citations

Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus

1986 • 137 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

Amplification of human int-2 in breast cancers and squamous carcinomas.

1988 • 125 citations

Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.

1989 • 123 citations

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17

1987 • 122 citations

The int genes in mammary tumorigenesis and in normal development

1988 • 117 citations

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.

1987 • 116 citations

Long terminal repeats of endogenous mouse mammary tumour virus contain a long open reading frame which extends into adjacent sequences

1982 • 114 citations

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

1988 • 111 citations

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.

1985 • 110 citations

Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.

1988 • 107 citations

The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.

1985 • 106 citations

Interaction Between Viral and Genetic Factors in Murine Mammary Cancer

1978 • 97 citations

Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

1988 • 95 citations

Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.

1988 • 93 citations

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway.

1987 • 91 citations

The activation of cellular oncogenes by retroviral insertion

1986 • 87 citations

Identification of protein products encoded by the proto-oncogene int-1.

1987 • 80 citations

Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis

1989 • 74 citations

Isolation of theXenopusbomolog ofint-1/winglessand expression during neurula stages of early development

1989 • 73 citations

Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development

1984 • 70 citations

Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene

1989 • 70 citations

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.

1989 • 67 citations

Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family.

1988 • 67 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Inducible overexpression and secretion of int-1 protein.

1989 • 62 citations

COAMPLIFICATION OF THE hst‐1 AND int‐2 GENES IN HUMAM CANCERS

1988 • 61 citations

A new site of integration for mouse mammary tumor virus proviral DNA common to BALB/cf(C3H) mammary and kidney adenocarcinomas.

1986 • 60 citations

Molecular Cloning and Chromosomal Assignment of the Human Homolog of int-1, a Mouse Gene Implicated in Mammary Tumorigenesis

1984 • 59 citations

The Wnt-1 (int-1) Oncogene Promoter and Its Mechanism of Activation by Insertion of Proviral DNA of the Mouse Mammary Tumor Virus

1990 • 59 citations

The mouse homologue ofhst/ k-FGF: sequence, genome organization and location relative toint-2

1989 • 51 citations

Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.

1984 • 48 citations

Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice

1987 • 47 citations

int-1--a proto-oncogene involved in cell signalling.

1989 • 46 citations

The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.

1990 • 38 citations

Cloned hst gene from normal human leukocyte DNA transforms NIH3T3 cells

1988 • 38 citations

Proviral insertions within the int-2 gene can generate multiple anomalous transcripts but leave the protein-coding domain intact

1990 • 33 citations

Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2.

1989 • 33 citations

Transient Expression of the Proto-Oncogene int-1 during Differentiation of P19 Embryonal Carcinoma Cells

1989 • 33 citations

Oncogene expression during progression of mouse mammary tumor cells; activity of a proviral enhancer and the resulting expression of int-2 is influenced by the state of differentiation.

1987 • 33 citations

The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2.

1988 • 32 citations

Mouse mammary tumor virus mediated transfer and expression of neomycin resistance to infected cultured cells

1986 • 32 citations

The int-1 proto-oncogene is transcriptionally activated during neuroectodermal differentiation of P19 mouse embryonal carcinoma cells.

1989 • 32 citations

Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain

1990 • 31 citations

Breast Cancer: Origins, Detection, and Treatment

1986 • 30 citations

Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.

1989 • 25 citations

Insertion elements and transitions in cloned mouse mammary tumour virus DNA: further delineation of the poison sequences

1986 • 25 citations

The activation of cellular oncogenes by proviral insertion in murine mammary cancer

1988 • 23 citations

Construction of a retroviral cDNA version of the int-l mammary oncogene and its expression in vitro

1986 • 19 citations

A putative int domain for mouse mammary tumor virus on mouse chromosome 7 is a 5' extension of int-2

1989 • 19 citations

Transactivating potential of the 3' open reading frame of murine mammary tumor virus

1988 • 19 citations

Amplification of the human putative oncogene INT1 in primary retinoblastoma tumors

1988 • 18 citations

Activation of int-1 and int-2 loci in GRf mammary tumors

1986 • 17 citations

Drosophila homolog of the murine Int-1 protooncogene.

1988 • 16 citations

Isolation of a pathogenic clone of mouse mammary tumor virus

1989 • 13 citations

A rare common integration site of proviruses of the mouse mammary tumor virus in P-type mammary tumors of mouse strain GR

1987 • 10 citations

Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammary tumor.

1990 • 9 citations

Molecular cloning and localization to chromosome 6 of mouseINT1L1 gene

1989 • 8 citations

The Importance of Epithelial-Stromal Interaction in Mammary Gland Development

1986 • 7 citations