Blood—Brain Barrier: Transport Studies in Isolated Brain Capillaries and in Cultured Brain Endothelial Cells

A new natriuretic peptide in porcine brain

1988 • 1,811 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Transferrin receptor on endothelium of brain capillaries

1984 • 1,008 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Brain metabolism: a perspective from the blood-brain barrier

1983 • 745 citations

An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

1990 • 534 citations

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

1987 • 523 citations

The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids

1970 • 511 citations

Transport of glucose from blood to brain.

1979 • 477 citations

Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids

1973 • 424 citations

γ-Glutamyl Transpeptidase in Isolated Brain Endothelial Cells: Induction by Glial Cells in Vitro

1980 • 404 citations

HORMONAL REGULATION OF MAMMALIAN GLUCOSE TRANSPORT

1986 • 399 citations

Tight junctions of brain endothelium in vitro are enhanced by astroglia

1987 • 389 citations

Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells

1980 • 389 citations

Human Blood—Brain Barrier Insulin Receptor

1985 • 386 citations

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

1974 • 372 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

Human blood-brain barrier transferrin receptor

1987 • 347 citations

Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries

1978 • 335 citations

Brain microvessel endothelial cells in tissue culture: A model for study of blood‐brain barrier permeability

1983 • 320 citations

Isolation of metabolically active capillaries from rat brain^1,2

1975 • 316 citations

Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport.

1987 • 314 citations

Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

1986 • 309 citations

Implications of the Blood-Brain Barrier and Its Manipulation

1989 • 308 citations

The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.

1990 • 272 citations

γ-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino Acids

1974 • 269 citations

Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

1986 • 246 citations

Identification of Hypoxanthine Transport and Xanthine Oxidase Activity in Brain Capillaries

1985 • 239 citations

Independent blood-brain barrier transport systems for nucleic acid precursors

1975 • 238 citations

Primary culture of capillary endothelium from rat brain

1981 • 234 citations

Isolated Brain Microvessels: A Purified, Metabolically Active Preparation from Bovine Cerebral Cortex

1974 • 226 citations

CARRIER MEDIATED BLOOD‐BRAIN BARRIER TRANSPORT OF CHOLINE AND CERTAIN CHOLINE ANALOGS

1978 • 223 citations

Disposition characteristics of macromolecules in tumor-bearing mice.

1990 • 220 citations

Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein.

1989 • 211 citations

Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term Culture

1989 • 210 citations

Neutral amino acid transport at the human blood-brain barrier.

1988 • 191 citations

Transcytotic pathway for blood-borne protein through the blood-brain barrier.

1988 • 188 citations

Bovine Brain Microvessel Endothelial Cell Monolayers as a Model System for the Blood‐Brain Barriera

1987 • 177 citations

Insulin binds to brain blood vessels in vivo

1979 • 177 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Induction of γ-glutamyl transpeptidase in cultured cerebral endothelial cells by a product released by astrocytes

1987 • 164 citations

Glial Cells Influence Polarity of the Blood-Brain Barrier

1984 • 164 citations

A Direct In Vitro Demonstration of Insulin Binding to Isolated Brain Microvessels

1981 • 161 citations

The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain

1985 • 158 citations

Human blood-brain barrier insulin-like growth factor receptor

1988 • 155 citations

Isolation of brain capillaries: a simplified technique

1976 • 154 citations

Primary culture of rat cerebral microvascular endothelial cells. Isolation, growth, and characterization.

1982 • 139 citations

Isolation and Characterization of Brain Endothelial Cells: Morphology and Enzyme Activity

1980 • 137 citations

Hexose transport and phosphorylation by capillaries isolated from rat brain

1979 • 135 citations

Cerebral microvessels and derived cells in tissue culture: Isolation and preliminary characterization

1979 • 133 citations

Sodium Transport in Capillaries Isolated from Rat Brain

1983 • 128 citations

Isolated microvessels: the blood-brain barrier in vitro.

1978 • 126 citations

Relation of potassium transport to oxidative metabolism in isolated brain capillaries

1979 • 125 citations

Rapid Sequestration and Degradation of Somatostatin Analogues by Isolated Brain Microvessels

1985 • 123 citations

Capillary transport of amino acids in the developing brain

1976 • 122 citations

Characteristics of the Large Neutral Amino Acid Transport System of Bovine Brain Microvessel Endothelial Cell Monolayers

1986 • 122 citations

Characterization of ?-glutamyl transpeptidase activity of cultured endothelial cells from porcine brain capillaries

1989 • 122 citations

Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

1987 • 120 citations

Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults

1982 • 117 citations

Saturable transport of peptides across the blood-brain barrier

1987 • 115 citations

Glial cells influence membrane-associated enzyme activity at the blood-brain barrier

1986 • 115 citations

Cerebral microvessels and derived cells in tissue culture

1981 • 112 citations

Brain microvessels take up large neutral amino acids in exchange for glutamine. Cooperative role of Na+-dependent and Na+-independent systems.

1983 • 112 citations

ALUMINIUM INCREASES PERMEABILITY OF THE BLOOD-BRAIN BARRIER TO LABELLED DSIP AND β-ENDORPHIN: POSSIBLE IMPLICATIONS FOR SENILE AND DIALYSIS DEMENTIA

1983 • 110 citations

Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

1986 • 110 citations

Cultured human and canine endothelial cells from brain microvessels

1988 • 110 citations

Enkephalin and Blood-Brain Barrier: Studies of Binding and Degradation in Isolated Brain Micro vessels*

1981 • 106 citations

Endothelial cell cultures derived from isolated cerenrbal microvessels

1980 • 105 citations

Carrier‐mediated transport of vasorpressin across the blood‐brain barrier of the mouse

1987 • 102 citations

Cerebral Vessels Have the Capacity to Transport Sodium and Potassium

1979 • 99 citations

Evidence for the presence of viable endothelial cells in cultures derived from dissociated rat brain

1978 • 98 citations

Permeability and mechanism of albumin, cationized albumin, and glycosylated albumin transcellular transport across monolayers of cultured bovine brain capillary endothelial cells.

1989 • 90 citations

Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier

1988 • 90 citations

Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayers

1990 • 87 citations

Sodium Transport from Blood to Brain: Inhibition by Furosemide and Amiloride

1983 • 86 citations

Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary culture.

1988 • 86 citations

Drug Delivery to the Central Nervous System: General Principles and Relevance to Therapy for Infections of the Central Nervous System

1989 • 84 citations

Enhanced Insulin Binding to Blood-Brain Barrier In Vivo and to Brain Microvessels In Vitro in Newborn Rabbits

1985 • 83 citations

Neutral Amino Acid Transport Properties of Cerebral Endothelial Cells in Vitro

1983 • 82 citations

Angiotensin II receptor binding sites in brain microvessels.

1985 • 81 citations

The application of bovine brain microvessel endothelial-cell monolayers grown onto polycarbonate membranes in vitro to estimate the potential permeability of solutes through the blood-brain barrier.

1989 • 79 citations

Stimulation of Glucose Analogue Uptake by Cerebral Microvessel Endothelial Cells by a Product Released by Astrocytes

1989 • 78 citations

Developmental changes in metabolism and transport properties of capillaries isolated from rat brain.

1981 • 77 citations

Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier

1987 • 76 citations

Microvessels Isolated from Rat Brain: Localization of Astrocyte Processes by Immunohistochemical Techniques

1981 • 75 citations

Catecholamine‐Metabolizing Enzymes of Bovine Brain Microvessel Endothelial Cell Monolayers

1986 • 74 citations

Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers

1990 • 73 citations

Uptake of Amino Acids by Brain Microvessels Isolated from Rats after Portacaval Anastomosis

1981 • 72 citations

Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood-brain barrier

1987 • 66 citations

Transport of histone through the blood-brain barrier.

1989 • 64 citations

Isolation and characterization of endothelial cells from rat and cow brain white matter.

1979 • 64 citations

Pathophysiology of Cerebral Energy Metabolism

1979 • 63 citations

γ-Glutamyltranspeptidase induction mediated by glial foot process-to endothelium contact in co-culture

1981 • 57 citations

A direct in vitro demonstration of insulin binding to isolated brain microvessels

1981 • 57 citations

Hyperosmotic arabinose solutions open the tight junctions between brain capillary endothelial cells in tissue culture

1984 • 57 citations

Long-term serial cultivation of arterial and capillary endothelium from adult bovine brain

1985 • 56 citations

CARRIER MEDIATED GLUCOSE TRANSPORT IN CAPILLARIES ISOLATED FROM RAT BRAIN¹

1977 • 55 citations

Transport of potassium at the blood—brain barrier

1972 • 55 citations

Phenylalanine Transport at the Human Blood-Brain Barrier

1988 • 55 citations

Isolation and culture of cells derived from human cerebral microvessels

1987 • 54 citations

Gamma-glutanyl-transpeptidase (GGTP) and NA+K+-ATPase activities in different subpopulations of cloned cerebral endothelial cells: Reponses to glial stimulation

1990 • 54 citations

Uptake of Adenosine by Isolated Rat Brain Capillaries

1982 • 54 citations

Relationship of octanol/buffer and octanol/water partition coefficients to transcellular diffusion across brain microvessel endothelial cell monolayers

1986 • 53 citations

TRANSPORT OF SUGARS INTO MICROVESSELS ISOLATED FROM RAT BRAIN: A MODEL FOR THE BLOOD‐BRAIN BARRIER¹

1979 • 53 citations

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

1986 • 51 citations

Angiotensin Peptide Regulation of Fluid-Phase Endocytosis in Brain Microvessel Endothelial Cell Monolayers

1990 • 49 citations

Specific binding of atrial natriuretic factor in brain microvessels.

1987 • 48 citations

Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits

1985 • 46 citations

Isolated brain capillaries: A model for the study of lead encephalopathy

1977 • 45 citations

Heterogeneity of intimal and microvessel endothelial cell barriers in vitro

1986 • 45 citations

Uptake of <scp>l</scp>‐[³⁵S]Cystine by Isolated Rat Brain Capillaries

1980 • 45 citations

Capacity for energy metabolism in microvessels isolated from rat brain

1984 • 42 citations

Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cells.

1989 • 39 citations

Characteristics of Aminopeptidase Activity from Bovine Brain Microvessel Endothelium

1987 • 38 citations

Choline Uptake by Cerebral Capillary Endothelial Cells in Culture

1990 • 36 citations

Kinetics of Choline Uptake into Isolated Rat Forebrain Microvessels: Evidence of Endocrine Modulation

1988 • 36 citations

In-vitro Characterization of Blood-brain Barrier Permeability to Delta Sleep-inducing Peptide

1989 • 35 citations

Uptake of Glucose Analogues into Cultured Cerebral Microvessel Endothelium

1985 • 34 citations

Identification of the insulin receptor of cerebral microvessels

1985 • 34 citations

History of the Blood-Brain Barrier Concept

1989 • 34 citations

Characterization of specific receptors for atrial natriuretic factor on cultured bovine brain capillary endothelial cells

1988 • 32 citations

Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain

1989 • 31 citations

Aluminum effects on brain microvessel endothelial cell monolayer permeability

1988 • 31 citations

Ischemic and post-ischemic effects on the 2-deoxy-D-[3H]glucose uptake in cerebral capillaries

1977 • 29 citations

Inhibition by steroids of the uptake of potassium by capillaries isolated from rat brain

1981 • 28 citations

A comparative study on the uptake and subsequent decarboxylation of monoamine precursors in cerebral microvessels

1979 • 27 citations

Uptake of L‐[¹⁴C]Proline by Isolated Rat Brain Capillaries

1983 • 27 citations

The Basis for Active Transport at the Blood-Brain Barrier

1980 • 26 citations

Culture of mouse brain capillary endothelial cell lines that express factor VIII, γ-glutamyl transpeptidase, and form junctional complexes in vitro

1987 • 25 citations

Uptake of adenosine into cultured cerebral endothelium

1983 • 25 citations

The uptake and fate of the radiolabeled 5-hydroxytryptamine in isolated cerebral microvessels

1981 • 25 citations

Cerebromicrovascular endothelial permeability

1987 • 23 citations

Establishment and preliminary growth characteristics of a transformed mouse cerebral microvessel endothelial cell line.

1986 • 22 citations

Phorbol ester stimulates hexose uptake by brain microvessel endothelial cells

1988 • 21 citations

Transport of Macromolecules Across the Capillary Endothelium

1991 • 21 citations

Demonstration of Acid Hydrolase Activity in Primary Cultures of Bovine Brain Microvessel Endothelium

1989 • 20 citations

Metabolism of Catecholamine Esters by Cultured Bovine Brain Microvessel Endothelial Cells

1989 • 20 citations

Substrate specificity of phenol sulfotransferase from primary cultures of bovine brain microvessel endothelium

1989 • 20 citations

Changes in the capillary lactate and 2-deoxy-D-glucose uptake in developing brain

1978 • 17 citations

Glucose Transfer across the Blood-Brain Barrier

1983 • 16 citations

Transport of Sodium and Potassium across the Blood-Brain Barrier

1980 • 15 citations

New Directions in Blood‐Brain Barrier Researcha

1988 • 14 citations

Cultured bovine brain capillary endothelial cells (BBCEC) - a blood-brain barrier model for studying the binding and internalization of insulin and insulin-like growth factor 1

1987 • 13 citations

Insulin increases entrane of 2-deoxy-d-[3H]glucose in isolated rat brain microvessels

1983 • 12 citations

Characteristics of Some Monoamine Uptake Systems in Isolated Cerebral Capillaries

1980 • 11 citations

The effect of in vitro and in vivo lead intoxication on monosaccharide transport in isolated rat brain microvessels

1980 • 11 citations

Aluminum effects on growth of brain microvessel endothelial cells in primary culture.

1988 • 11 citations

Cerebral microvessel 2‐deoxy‐<scp>D</scp>‐glucose uptake during ischemia‐induced seizures

1980 • 11 citations

Blood-brain barrier: Mechanisms of peptide regulation and transport

1990 • 10 citations

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by bovine brain microvessel endothelial cells

1989 • 9 citations

Attenuated Blood-Brain Barrier

1984 • 8 citations

Transport Phenomena in Cerebral Ischemia

1979 • 6 citations

In vitro of peptide transport through a cell culture model of the blood-brain barrier

1990 • 2 citations