Molecular Mechanisms of Acidosis-Mediated Damage

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Metabolic regulation via intracellular pH

1984 • 674 citations

Free Radicals and Brain Damage

1993 • 527 citations

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca²⁺ and Na⁺: Implications for Neurodegeneration

1994 • 492 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Mechanisms of ischemic brain damage

1988 • 426 citations

Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.

1994 • 421 citations

Brain Lactic Acidosis and Ischemic Cell Damage: 2. Histopathology

1981 • 396 citations

Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats

2009 • 382 citations

What causes infarction in ischemic brain?

1983 • 382 citations

Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia.

1979 • 379 citations

Calcium Accumulation and Neuronal Damage in the Rat Hippocampus following Cerebral Ischemia

1987 • 374 citations

Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures

1990 • 372 citations

Oxygen radicals in cerebral ischemia

1992 • 332 citations

Regional Accumulation of Calcium in Postischemic Rat Brain

1984 • 320 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification.

1993 • 286 citations

Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro

1985 • 278 citations

Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage.

1986 • 258 citations

Lipid peroxidation: its measurement, occurrence, and significance in animal tissues.

1967 • 250 citations

Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation

1990 • 202 citations

Enhancement of Iron-Catalyzed Free Radical Formation by Acidosis in Brain Homogenates: Difference in Effect by Lactic Acid and CO₂

1989 • 201 citations

Acid-Base Homeostasis in the Brain: Physiology, Chemistry, and Neurochemical Pathology

1985 • 199 citations

Effects of Intracellular H+ on the Electrical Properties of Excitable Cells

1984 • 198 citations

Microvascular changes during cerebral ischemia and reperfusion.

1994 • 194 citations

Evolving Concepts About the Role of Acidosis in Ischemic Neuropathology

1993 • 191 citations

Respiratory Activity of Isolated Rat Brain Mitochondria followingin vitroExposure to Oxygen Radicals

1983 • 181 citations

Mechanisms of brain damage in focal cerebral ischemia

1988 • 166 citations

Altered Mitochondrial Respiration in Selectively Vulnerable Brain Subregions Following Transient Forebrain Ischemia in the Rat

1987 • 159 citations

Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction

1987 • 157 citations

Calcium in the mitochondria following brief ischemia of gerbil brain

1987 • 151 citations

Acidosis-related brain damage.

1993 • 143 citations

Lactic Acidosis and Recovery of Mitochondrial Function following Forebrain Ischemia in the Rat

1985 • 139 citations

Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration

1987 • 134 citations

The Calcium Content of Mitochondria from Brain Subregions Following Short‐Term Forebrain Ischemia and Recirculation in the Rat

1994 • 130 citations

Brain lactic acidosis and ischemic cell damage: Quantitative ultrastructural changes in capillaries of rat cerebral cortex

1983 • 125 citations

Acidosis Induced by Hypercapnia Exaggerates Ischemic Brain Damage

1994 • 123 citations

Influence of in vitro Lactic Acidosis and Hypercapnia on Respiratory Activity of Isolated Rat Brain Mitochondria

1984 • 121 citations

Carbonic acid buffer changes during complete brain ischemia

1986 • 121 citations

Glial swelling during extracellular acidosis in vitro.

1988 • 120 citations

Cerebrovascular Diseases

1988 • 114 citations

Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil

1977 • 113 citations

Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids

1978 • 113 citations

Ischemia in normo- and hyperglycemic rats: effects on brain water and electrolytes.

1987 • 111 citations

Motor neuron disease in Cantabria

1988 • 106 citations

Generation of superoxide anion by brain endothelial cell xanthine oxidase

1991 • 100 citations

Extra‐ and Intracellular pH in the Brain During Ischaemia, Related to Tissue Lactate Content in Normo‐and Hypercapnic rats

1992 • 92 citations

Inflammatory reactions at the blood-endothelial interface in acute stroke.

1996 • 89 citations

A possible mechanism of mitochondrial dysfunction during cerebral ischemia: Inhibition of mitochondrial respiration activity by arachidonic acid

1991 • 86 citations

Ischemia‐Induced Changes in Cerebral Mitochondrial Free Fatty Acids, Phospholipids, and Respiration in the Rat

1994 • 81 citations

Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels

1993 • 63 citations

Preischemic Hyperglycemia Enhances Postischemic Depression of Cerebral Metabolic Rate

1989 • 63 citations

Delayed decreases in specific brain mitochondrial electron transfer complex activities and cytochrome concentrations following anoxia/ischemia

1990 • 57 citations

Selective Reductions in the Activity of the Pyruvate Dehydrogenase Complex in Mitochondria Isolated from Brain Subregions following Forebrain Ischemia in Rats

1993 • 57 citations

Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia

1988 • 55 citations

Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats.

1993 • 49 citations

Effect of Peroxide, Sodium, and Calcium on Brain Mitochondrial Respiration In Vitro: Potential Role in Cerebral Ischemia and Reperfusion

1990 • 45 citations

Degradation of Mitochondrial Phospholipids During Experimental Cerebral Ischemia in Rats

1991 • 44 citations

The Influence of Acidosis on Hypoglycemic Brain Damage

1995 • 35 citations

Hyperglycemia Suppresses c-FosmRNA Expression following Transient Cerebral Ischemia in Gerbils

1992 • 32 citations

Delayed Neurologic Deterioration Following Anoxia: Brain Mitochondrial and Metabolic Correlates

1989 • 29 citations

Effects of dimethylthiourea on ischemic brain damage in hyperglycemic rats

1992 • 20 citations

Cerebrovascular Diseases

1985 • 18 citations

Influence of cerebral ischemia and post-ischemic reperfusion on mitochondrial oxidative phosphorylation

1990 • 17 citations

Catabolism of mitochondrial membrane phospholipids in conditions of ischemia and barbiturate anesthesia.

1977 • 13 citations