Effects of dimethylthiourea on ischemic brain damage in hyperglycemic rats

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1984 • 968 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Moderate hyperglycemia augments ischemic brain damage

1982 • 730 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Brain Lactic Acidosis and Ischemic Cell Damage: 1. Biochemistry and Neurophysiology

1981 • 585 citations

Free Radicals and Brain Damage

1993 • 527 citations

Nervous System Effects of Cardiac Arrest in Monkeys

1977 • 408 citations

Brain Lactic Acidosis and Ischemic Cell Damage: 2. Histopathology

1981 • 396 citations

Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats

2009 • 382 citations

Acidosis and ischemic brain damage

1988 • 378 citations

Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger.

1988 • 377 citations

Significance of xanthine oxidase in capillary endothelial cells.

1986 • 333 citations

Hypoglycemic Brain Injury in the Rat: Correlation of Density of Brain Damage with the EEG Isoelectric Time: A Quantitative Study

1984 • 328 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

Status epilepticus in well–oxygenated rats causes neuronal necrosis

1985 • 312 citations

Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization.

1980 • 294 citations

Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema

1987 • 283 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro

1985 • 278 citations

Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.

1980 • 277 citations

21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.

1988 • 266 citations

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.

1990 • 266 citations

Lipid peroxidation: its measurement, occurrence, and significance in animal tissues.

1967 • 250 citations

Hydrogen Ions Kill Brain at Concentrations Reached in Ischemia

1987 • 237 citations

Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats.

1989 • 237 citations

Excessive cellular acidosis: an important mechanism of neuronal damage in the brain?

1980 • 218 citations

Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia

1974 • 215 citations

Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.

1988 • 208 citations

Chronic Granulomatous Disease

1987 • 204 citations

Progression and Generalization of Seizure Discharge: Anatomical and Neurochemical Substrates

1988 • 203 citations

Enhancement of Iron-Catalyzed Free Radical Formation by Acidosis in Brain Homogenates: Difference in Effect by Lactic Acid and CO₂

1989 • 201 citations

Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.

1985 • 191 citations

Advances in Perinatal Neurology

1980 • 179 citations

The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of α1-antiproteinase against inactivation by hypochlorous acid

1987 • 170 citations

Comparison of the capacities of the perhydroxyl and the superoxide radicals to initiate chain oxidation of linoleic acid

1981 • 168 citations

Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea.

1987 • 168 citations

Astrocytic Acidosis in Hyperglycemic and Complete Ischemia

1990 • 165 citations

Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats.

1989 • 162 citations

Recirculation in the Rat Brain following Incomplete Ischemia

1983 • 159 citations

Substantia nigra-mediated anticonvulsant actions: Role of nigral output pathways

1987 • 155 citations

Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico‐Striatal Transmitter

1982 • 153 citations

Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: Effects of intranigral 2-amino-7-phosphonoheptanoate and n-methyl-d-aspartate

1986 • 143 citations

The Effect of pH upon Human Transferrin: Selective Labelling of the Two Iron‐binding Sites

1976 • 137 citations

The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat

1984 • 133 citations

Morphological lesions in the brain preceding the development of postischemic seizures

1988 • 131 citations

Prevention of reperfusion injury in the neonatal heart with leukocyte-depleted blood

1989 • 127 citations

Ferritin: an iron-storage molecule.

1977 • 118 citations

GABA in Epilepsy: The Pharmacologic Basis

1989 • 116 citations

Cerebrovascular Diseases

1988 • 114 citations

Ischemia in normo- and hyperglycemic rats: effects on brain water and electrolytes.

1987 • 111 citations

Free radical production and ischemic brain damage: Influence of postischemic oxygen tension

1991 • 97 citations

Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen.

1987 • 94 citations

Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats.

1988 • 87 citations

Failure of GABAergic inhibition: a key to local and global seizures.

1986 • 82 citations

Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study

1984 • 73 citations

Dimethylthiourea Reduces Ischemic Brain Edema without Affecting Cerebral Blood Flow

1990 • 63 citations

Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats

1986 • 59 citations

Acidosis-Induced Ischemic Brain Damage: Are Free Radicals Involved?

1991 • 55 citations

Some Physicochemical Aspects of Iron Metabolism

1977 • 51 citations

Influence of moderate hypothermia on ischemic brain damage incurred under hyperglycemic conditions

1991 • 43 citations

The effect of glucose upon restitution after transient cerebral ischemia: A summary

2009 • 39 citations

Substantia nigra damage induced by ischemia in hyperglycemic rats

1987 • 36 citations

Pathogenesis of Substantia Nigra Lesions following Hyperglycemic Ischemia: Changes in Energy Metabolites, Cerebral Blood Flow, and Morphology of Pars Reticulata in a Rat Model of Ischemia

1988 • 33 citations

Preischemic Hyperglycemia and Postischemic Alteration of Rat Brain Pyruvate Dehydrogenase Activity

1990 • 27 citations

Ischemic brain damage is not ameliorated by 1,3-butanediol in hyperglycemic rats.

1992 • 9 citations

Frontal cortex lesion prior to hyperglycemic ischemia: no decrease in ensuing substantia nigra pars reticulata damage or fatal post-ischemic seizures

1992 • 4 citations