Antiapoptotic Effect and Inhibition of Ischemia/Reperfusion-Induced Myocardial Injury in Metallothionein-Overexpressing Transgenic Mice

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1979 • 27,693 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Myocardial ischemia and reperfusion: a murine model

1995 • 424 citations

Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

1997 • 249 citations

Inhibition of cell membrane lipid peroxidation by cadmium- and zinc-metallothioneins

1986 • 241 citations

The role of mitochondria in ischemia/reperfusion injury

2002 • 224 citations

Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein

1989 • 218 citations

Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.

1993 • 214 citations

Apoptosis in Myocardial Ischemia‐Reperfusion

1999 • 214 citations

Suppression by Metallothionein of Doxorubicin-induced Cardiomyocyte Apoptosis through Inhibition of p38 Mitogen-activated Protein Kinases

2000 • 209 citations

Myocardial reperfusion injury: Role of oxygen radicals and potential therapy with antioxidants

1994 • 200 citations

The Antioxidant Function of Metallothionein in the Heart

1999 • 184 citations

Oxidative Stress Developed During the Reperfusion of Ischemic Myocardium Induces Apoptosis

1998 • 179 citations

Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes.

2001 • 167 citations

[13] Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay

1991 • 157 citations

Metallothionein Inhibits Peroxynitrite-induced DNA and Lipoprotein Damage

2000 • 155 citations

Myocardial ischemia, reperfusion and free radical injury

1990 • 134 citations

Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart.

2001 • 128 citations

Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis

1998 • 119 citations

Activation of caspases triggered by cytochrome c in vitro¹

1998 • 113 citations

Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischemia and reperfusion.

1990 • 96 citations

Specific Reduction of Toxic Side Effects of Adriamycin by Induction of Metallothionein in Mice

1988 • 74 citations

Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes

2001 • 64 citations

Tissue specific induction of metallothionein synthesis by tumor necrosis factor-alpha.

1992 • 60 citations

Metallothionein inhibits ischemia-reperfusion injury in mouse heart

1999 • 58 citations

Distal Regulatory Elements from the Mouse Metallothionein Locus Stimulate Gene Expression in Transgenic Mice

1993 • 58 citations

Cupric nitrilotriacetate-induced apoptosis in HL-60 cells

1999 • 50 citations

PROTECTION OF THE ISCHEMIC HEART WITH DMSO ALONE OR DMSO WITH HYDROGEN PEROXIDE*

1967 • 41 citations

Oxidative stress during reperfusion of human hearts: potential sources of oxygen free radicals

1995 • 40 citations

[Changes in myocardial metallothionein on isoproterenol-induced myocardial injury].

1993 • 11 citations

Changes of Myocardial Metallotionein on Isoproterenol-Induced Myocardial Injury

1993 • 9 citations

The role of hepatobiliary scintigraphy in the evaluation of the protective effects of dimethylsulphoxide in ischaemic/reperfusion injury of liver

2000 • 8 citations

The comparison of electron microscopy and scintigraphy in determining the protective effect of dimethylsulphoxide (DMSO) on ischemia/reperfusion injury through Pringle maneuver.

2001 • 8 citations

Oxidative stress during reperfusion of human hearts: potential sources of oxygen free radicals*1

1995 • 7 citations

Studies on Early Changes in Myocardial Electrolytes and Histological Reaction in Isoproterenol-Induced Myocardial Injury

1991 • 4 citations