Phenotypic and Functional Changes Induced at the Clonal Level in Hematopoietic Stem Cells After 5-Fluorouracil Treatment

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

The aging of hematopoietic stem cells

1996 • 850 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

The purification and characterization of fetal liver hematopoietic stem cells.

1995 • 607 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells

1992 • 520 citations

Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?

1979 • 513 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Clonal analysis of hematopoietic stem-cell differentiation in vivo.

1991 • 379 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function

1995 • 340 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Competitive repopulation: a new assay for long-term stem cell functional capacity

1980 • 332 citations

5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.

1990 • 247 citations

Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil

1991 • 240 citations

Studies of hematopoietic stem cells spared by 5-fluorouracil.

1984 • 213 citations

Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity

1996 • 199 citations

Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells.

1992 • 160 citations

Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells

1996 • 140 citations

Survival and retrovirus infection of murine hematopoietic stem cells in vitro: effects of 5-FU and method of infection.

1991 • 137 citations

Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures

1995 • 131 citations

[19] Fluorescence-activated cell sorting: Theory, experimental optimization, and applications in lymphoid cell biology

1984 • 127 citations

The organization of hemopoietic tissue as inferred from the effects of 5-fluorouracil.

1982 • 122 citations

Stage-specific expression of c-kit protein by murine hematopoietic progenitors

1993 • 121 citations

Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil- treated murine marrow

1993 • 97 citations

The effects of 5-fluorouracil on hematopoiesis: studies of murine megakaryocyte-CFC, granulocyte-macrophage-CFC, and peripheral blood cell levels.

1983 • 65 citations

Large numbers of primitive stem cells are active simultaneously in aggregated embryo chimeric mice

1987 • 60 citations

Modulation of c-kit mRNA and protein by hemopoietic growth factors.

1991 • 53 citations

Long-term repopulation of hematolymphoid cells with only a few hemopoietic stem cells in mice.

1995 • 50 citations

Separation of pluripotent stem cells and early B lymphocyte precursors with antibody Fall-3.

1991 • 35 citations

High-frequency cell surface expression of a foreign protein in murine hematopoietic stem cells using a new retroviral vector

1996 • 29 citations

Enrichment for primitive hemopoietic progenitors of marrow cells from 5-fluorouracil-treated mice and normal mice.

1994 • 11 citations

Regulation of c-kit expression in human myeloid cells

1996 • 9 citations