Regulation of Insulin Secretion in Vivo

Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.

1981 • 1,606 citations

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

1993 • 1,516 citations

Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function

1993 • 1,391 citations

Prevalence of Diabetes and Impaired Glucose Tolerance and Plasma Glucose Levels in U.S. Population Aged 20–74 Yr

1987 • 1,072 citations

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

1967 • 908 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*

1999 • 650 citations

Concordance for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland

1992 • 635 citations

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

1992 • 612 citations

Islet Pathology and the Pathogenesis of Type 1 and Type 2 Diabetes mellitus Revisited

1985 • 580 citations

Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay

1963 • 573 citations

Abnormal Patterns of Insulin Secretion in Non-Insulin-Dependent Diabetes Mellitus

1988 • 565 citations

Concordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins

1987 • 519 citations

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1988 • 506 citations

Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance Tests

1976 • 493 citations

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

1999 • 483 citations

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1984 • 481 citations

Evaluation of Simple Indices of Insulin Sensitivity and Insulin Secretion for Use in Epidemioiogic Studies

2000 • 471 citations

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.

1983 • 466 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

1998 • 442 citations

Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

1995 • 435 citations

The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity

1998 • 421 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

Insulin release: The fuel hypothesis

1979 • 351 citations

Minimal Model Analysis of Intravenous Glucose Tolerance Test-Derived Insulin Sensitivity in Diabetic Subjects*

1990 • 342 citations

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

1998 • 324 citations

Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function

1993 • 320 citations

THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS

1901 • 298 citations

Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative

1995 • 289 citations

Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr

1987 • 287 citations

Decreased Insulin Secretion and Increased Insulin Resistance Are Independently Related to the 7-Year Risk of NIDDM in Mexican-Americans

1995 • 282 citations

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels

1999 • 276 citations

Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

1987 • 274 citations

Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man

1981 • 265 citations

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

1999 • 258 citations

Pulsatile Insulin Has Greater Hypoglycemic Effect Than Continuous Delivery

1983 • 248 citations

Pathophysiology of Insulin Secretion in Non-insulin-dependent Diabetes Mellitus

1984 • 221 citations

Insulin responses to glucose: evidence for a two pool system in man

1969 • 220 citations

Concordance rate for Type II diabetes mellitus in monozygotic twins: actuarial analysis

1999 • 218 citations

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

1997 • 217 citations

Release of Incompletely Processed Proinsulin Is the Cause of the Disproportionate Proinsulinemia of NIDDM

1997 • 212 citations

Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus.

1995 • 210 citations

Disproportionately Elevated Proinsulin Levels Reflect the Degree of Impaired B Cell Secretory Capacity in Patients with Noninsulin-Dependent Diabetes Mellitus¹

1998 • 206 citations

Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging

1990 • 198 citations

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in Type II diabetes

2000 • 192 citations

Increased β-Cell Secretory Capacity as Mechanism for Islet Adaptation to Nicotinic Acid-Induced Insulin Resistance

1989 • 181 citations

Control of pulsatile insulin secretion in man

1983 • 176 citations

Disproportionately Elevated Proinsulin in Pima Indians with Noninsulin-Dependent Diabetes Mellitus*

1990 • 171 citations

Pancreatic Beta-Cell Dysfunction as the Primary Genetic Lesion in NIDDM

1995 • 166 citations

Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands.

1998 • 158 citations

Disproportionately Elevated Proinsulin Levels Reflect the Degree of Impaired B Cell Secretory Capacity in Patients with Noninsulin-Dependent Diabetes Mellitus

1998 • 155 citations

Potentiation of Insulin Secretory Responses by Plasma Glucose Levels in Man: Evidence That Hyperglycemia in Diabetes Compensates for Impaired Glucose Potentiation*

1979 • 151 citations

Insulin Resistance and Impaired Insulin Secretion in Subjects with Histories of Gestational Diabetes Mellitus

1985 • 150 citations

Heritability of Pancreatic β-Cell Function among Nondiabetic Members of Caucasian Familial Type 2 Diabetic Kindreds¹

1999 • 145 citations

The Insulin Gene Contains Multiple Transcriptional Elements That Respond to Glucose

1994 • 145 citations

Earlier Appearance of Impaired Insulin Secretion Than of Visceral Adiposity in the Pathogenesis of NIDDM: 5-Year Follow-up of Initially Nondiabetic Japanese-American Men

1995 • 145 citations

Differential volumetry of A,B and D cells in the pancreatic islets of diabetic and nondiabetic subjects.

1979 • 142 citations

Sequence Variants in the Sulfonylurea Receptor (SUR) Gene Are Associated With NIDDM in Caucasians

1996 • 134 citations

Biosynthetic Human Proinsulin: Review of Chemistry, in Vitro and in Vivo Receptor Binding, Animal and Human Pharmacology Studies, and Clinical Trial Experience

1992 • 132 citations

Proinsulin as a Marker for the Development of NIDDM in Japanese-American Men

1995 • 130 citations

Antepartum predictors of the development of type 2 diabetes in Latino women 11-26 months after pregnancies complicated by gestational diabetes.

1999 • 129 citations

Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors.

1992 • 128 citations

Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20

1995 • 127 citations

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

1998 • 122 citations

The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity

1998 • 121 citations

Familiality of Quantitative Metabolic Traits in Finnish Families with Non-Insulin-Dependent Diabetes mellitus

1999 • 119 citations

Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins

2000 • 114 citations

Molecular Genetics of Maturity-onset Diabetes of the Young

1999 • 113 citations

Severe Diabetes Induced in Subtotally Depancreatized Dogs by Sustained Hyperglycemia

1988 • 113 citations

Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians.

1997 • 112 citations

Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic Beta cell

1991 • 112 citations

Reduced beta-cell compensation to the insulin resistance associated with obesity in members of caucasian familial type 2 diabetic kindreds.

2000 • 110 citations

Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans

1995 • 103 citations

Insulin Secretion in Normal Glucose-Tolerant Relatives of Type 2 Diabetic Subjects: Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests

1998 • 102 citations

Genetic Studies of the Sulfonylurea Receptor Gene Locus in NIDDM and in Morbid Obesity Among French Caucasians

1997 • 97 citations

Hexose metabolism in pancreatic islets

1990 • 96 citations

Treatment with a Somatostatin Analog Decreases Pancreatic B-Cell and Whole Body Sensitivity to Glucose*

1990 • 95 citations

Variants in the sulphonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians

1999 • 87 citations

Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects

1995 • 87 citations

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

1998 • 83 citations

Potentiation of insulin release by glucose in man. I. Quantitative analysis of the enhancement of glucose-induced insulin secretion by pretreatment with glucose in normal subjects.

1975 • 83 citations

The insulin gene contains multiple transcriptional elements that respond to glucose.

1994 • 83 citations

Abnormal Glucose Regulation of Insulin Secretion in Models of Reduced B-Cell Mass

1984 • 81 citations

Proinsulin and Specific Insulin Concentration in High- and Low-Risk Populations for NIDDM

1994 • 79 citations

The Effect of Rate and Dose of Glucose Infusion on the Acute Insulin Response in Man

1976 • 76 citations

POTENTIATION OF INSULIN RELEASE BY GLUCOSE IN MAN

1975 • 75 citations

Heritability of Pancreatic -Cell Function among Nondiabetic Members of Caucasian Familial Type 2 Diabetic Kindreds

1999 • 74 citations

Pulsatile insulin has greater hypoglycemic effect than continuous delivery

1983 • 74 citations

Reduction of Glycemic Potentiation: Sensitive Indicator of β-Cell Loss in Partially Pancreatectomized Dogs

1988 • 74 citations

Relationship of Islet Function to Insulin Action in Human Obesity*

1987 • 73 citations

A distinct difference in the metabolic stimulus–response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties

1998 • 72 citations

Reduced β-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding

1999 • 72 citations

Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man

1981 • 72 citations

Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity--clinical research center study.

1995 • 64 citations

Glucose intolerance is predicted by low insulin secretion and high glucagon secretion: outcome of a prospective study in postmenopausal Caucasian women

2000 • 63 citations

Intact proinsulin and beta-cell function in lean and obese subjects with and without type 2 diabetes.

1999 • 59 citations

Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM

1997 • 55 citations

Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus

1985 • 54 citations

Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging.

1992 • 53 citations

POTENTIATION OF INSULIN RELEASE BY GLUCOSE IN MAN

1975 • 51 citations

Proinsulin as a marker for the development of NIDDM in Japanese-American men

1995 • 49 citations

Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20

1995 • 49 citations

Natural History of Impaired Glucose Tolerance: Follow‐up at Joslin Clinic

1996 • 49 citations

Missense Mutations in the Human Insulin Promoter Factor-1 Gene and Their Relation to Maturity-Onset Diabetes of the Young and Late-Onset Type 2 Diabetes Mellitus in Caucasians*

2000 • 45 citations

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians

1996 • 44 citations

Linkage Analysis of Acute Insulin Secretion With GLUT2 and Glucokinase in Pima Indians and the Identification of a Missense Mutation in GLUT2

1994 • 43 citations

Basal and stimulated hyperinsulinism: reversible metabolic sequelae of obesity.

1974 • 38 citations

A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide and insulin.

1986 • 36 citations

Prospective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity

1999 • 36 citations

Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance

1989 • 36 citations

Effects of Dietary Treatment on Serum Insulin and Proinsulin Response in Newly Diagnosed NIDDM

1989 • 36 citations

The genetics of non-insulin-dependent diabetes mellitus: tools and aims

1994 • 35 citations

The Effect of Exogenous Hyperinsulinemia on Proinsulih Secretion in Normal Man, Obese Subjects, and Patients with Insulinoma*

1986 • 34 citations

History of Gestational Diabetes Leads to Distinct Metabolic Alterations in Nondiabetic African-American Women With a Parental History of Type 2 Diabetes

1998 • 34 citations

Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians

1997 • 32 citations

Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance

1991 • 32 citations

Missense Mutations in the Human Insulin Promoter Factor-1 Gene and Their Relation to Maturity-Onset Diabetes of the Young and Late-Onset Type 2 Diabetes Mellitus in Caucasians

2000 • 31 citations

Proinsulin and specific insulin concentration in high- and low-risk populations for NIDDM

1994 • 29 citations

Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass

1984 • 29 citations

Decreased glucose effectiveness but not insulin resistance in glucose-tolerant offspring of Japanese non—insulin-dependent diabetic patients: A minimal-model analysis

1997 • 29 citations

Biosynthesis of islet amyloid polypeptide. Elevated expression in mouse beta TC3 cells

1991 • 28 citations

Plasminogen Activator Inhibitor (PAI-1) Activity is Elevated in Asian and Caucasian Subjects with Non-insulin-dependent (Type 2) Diabetes but not in Those with Impaired Glucose Tolerance (IGT) or Non-diabetic Asians

1996 • 27 citations

Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia

1988 • 27 citations

Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging

1992 • 26 citations

Impact of family history of diabetes on the assessment of β-cell function

1998 • 24 citations

Oscillations in Activities of Enzymes in Pancreatic Islet Subcellular Fractions Induced by Physiological Concentrations of Effectors

1997 • 23 citations

Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2

1994 • 22 citations

Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity--clinical research center study

1995 • 22 citations

Effect of Epinephrine on Pancreatic β-cell and α-Cell Function in Patients With NIDDM

1991 • 18 citations

Reduction of glycemic potentiation. Sensitive indicator of beta-cell loss in partially pancreatectomized dogs

1988 • 17 citations

Hexose metabolism in pancreatic islets. Regulation of aerobic glycolysis and pyruvate decarboxylation

1991 • 16 citations

Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM

1989 • 14 citations

Glucokinase Gene Variations in Japanese-Americans With a Family History of NIDDM

1994 • 13 citations

Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals

1998 • 12 citations

The Prevalence of Low Insulin Responders to Oral Glucose Load Among Groups with Various Patterns of Family History of Diabetes

1996 • 9 citations

Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentrations of effectors

1997 • 6 citations

Effect of epinephrine on pancreatic beta-cell and alpha-cell function in patients with NIDDM

1991 • 5 citations

Cited By (0)

Loading...