Rnd Proteins: A New Family of Rho-Related Proteins That Interfere with the Assembly of Filamentous Actin Structures and Cell Adhesion

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.

1996 • 272 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Endosome dynamics regulated by a Rho protein

1996 • 225 citations

Farnesyltransferase Inhibition Causes Morphological Reversion of ras-Transformed Cells by a Complex Mechanism That Involves Regulation of the Actin Cytoskeleton

1994 • 197 citations

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.

1988 • 196 citations

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1997 • 192 citations

Cytoskeletal and adhesion proteins as tumor suppressors

1997 • 185 citations

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

1994 • 142 citations

The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers.

1995 • 113 citations

[21] In Vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases

1995 • 57 citations

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

1994 • 51 citations

Genomic Structure and Assignment of theRhoH/TTFSmall GTPase Gene (ARHH) to 4p13 byin SituHybridization

1997 • 39 citations

Mapping of ras-related GTP-binding proteins by GTP-overlay and 2D-gel analysis.

1994 • 36 citations