Apolipoprotein B mRNA Editing

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

1987 • 1,021 citations

Apolipoprotein B-48 Is the Product of a Messenger RNA with an Organ-Specific In-Frame Stop Codon

1987 • 746 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Complete protein sequence and identification of structural domains of human apolipoprotein B

1986 • 620 citations

Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein

1993 • 609 citations

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit) *1Incidence and development of atherosclerosis and xanthoma

1980 • 540 citations

Adenoviruses as Gene-Delivery Vehicles

1996 • 480 citations

Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100

1986 • 423 citations

Cytidine Deaminase. The 2·3 Å Crystal Structure of an Enzyme: Transition-state Analog Complex

1994 • 378 citations

Effects of ethanol on lipid metabolism.

1979 • 374 citations

The apolipoprotein multigene family: biosynthesis, structure, structure-function relationships, and evolution.

1988 • 315 citations

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

1995 • 286 citations

The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.

1993 • 286 citations

Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins

1993 • 272 citations

Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins.

1992 • 234 citations

The number of nucleotides required to determine the branching order of three species, with special reference to the human-chimpanzee-gorilla divergence

1986 • 234 citations

A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.

1997 • 226 citations

Structure of apolipoprotein B-100 of human low density lipoproteins.

1989 • 210 citations

On the evolution of RNA editing

1993 • 202 citations

Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA.

1988 • 191 citations

Progress in Transcriptionally Targeted and Regulatable Vectors for Genetic Therapy

1997 • 180 citations

Evolutionary origins of apoB mRNA editing: Catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site

1995 • 180 citations

An in vitro system for the editing of apolipoprotein B mRNA

1989 • 175 citations

Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48

1996 • 152 citations

Sequence requirements for the editing of apolipoprotein B mRNA.

1991 • 140 citations

Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.

1994 • 137 citations

Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation.

1991 • 131 citations

The Neurofibromatosis Type I Messenger RNA Undergoes Base-Modification RNA Editing

1996 • 128 citations

apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Is a Novel RNA-binding Protein

1995 • 123 citations

Antibodies to hnRNP core proteins inhibitin vitrosplicing of human β-globin pre-mRNA

1986 • 119 citations

Apolipoprotein B messenger RNA editing in the rat liver. Modulation by fasting and refeeding a high carbohydrate diet.

1990 • 114 citations

Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed.

1994 • 113 citations

Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins.

1993 • 107 citations

In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.

1991 • 103 citations

Complete Phenotypic Characterization of apobec-1 Knockout Mice with a Wild-type Genetic Background and a Human Apolipoprotein B Transgenic Background, and Restoration of Apolipoprotein B mRNA Editing by Somatic Gene Transfer of Apobec-1

1996 • 102 citations

Fasting decreases apolipoprotein B mRNA editing and the secretion of small molecular weight apoB by rat hepatocytes: evidence that the total amount of apoB secreted is regulated post-transcriptionally

1990 • 94 citations

Cloning of an Apobec-1-binding Protein That Also Interacts with Apolipoprotein B mRNA and Evidence for Its Involvement in RNA Editing

1997 • 93 citations

Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editingin vitro

1992 • 93 citations

Apolipoprotein B mRNA editing is associated with UV crosslinking of proteins to the editing site.

1993 • 92 citations

Adenovirus-mediated gene transfer of rat apolipoprotein B mRNA-editing protein in mice virtually eliminates apolipoprotein B-100 and normal low density lipoprotein production.

1994 • 91 citations

Alternative mRNA Splicing and Differential Promoter Utilization Determine Tissue-specific Expression of the Apolipoprotein B mRNA-editing Protein (Apobec1) Gene in Mice.

1995 • 90 citations

Apolipoprotein B mRNA editing: a new tier for the control of gene expression

1992 • 88 citations

Intron-dependent enzymatic formation of modified nucleosides in eukaryotic tRNAs: A review

1997 • 87 citations

Site-specific Mutagenesis Demonstrates That Cysteine 4326 of Apolipoprotein B Is Required for Covalent Linkage with Apolipoprotein(a) in Vivo

1995 • 85 citations

RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitro coupled transcription editing.

1990 • 85 citations

Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.

1996 • 84 citations

Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: functional role in the modulation of apoB mRNA editing.

1995 • 83 citations

Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein

1994 • 79 citations

Apolipoprotein B mRNA sequences 3′ of the editing site are necessary and sufficient for editing and editosome assembly

1991 • 76 citations

Apobec-1 Interacts with a 65-kDa Complementing Protein to Edit Apolipoprotein-B mRNA in Vitro

1996 • 75 citations

Apobec-1 and apolipoprotein B mRNA editing

1997 • 74 citations

Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins.

1982 • 71 citations

Apolipoprotein B mRNA editing. Validation of a sensitive assay and developmental biology of RNA editing in the rat.

1990 • 71 citations

A 40 kilodalton rat liver nuclear protein binds specifically to apolipoprotein B mRNA around the RNA editing site

1990 • 68 citations

Hepatic Expression of the Catalytic Subunit of the Apolipoprotein B mRNA Editing Enzyme (apobec-1) Ameliorates Hypercholesterolemia in LDL Receptor-Deficient Rabbits

1996 • 61 citations

Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing.

1994 • 61 citations

An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing.

1996 • 51 citations

Ethanol modulates apolipoprotein B mRNA editing in the rat.

1996 • 45 citations

Tissue-specific Inhibition of Apolipoprotein B mRNA Editing in the Liver by Adenovirus-mediated Transfer of a Dominant Negative Mutant APOBEC-1 Leads to Increased Low Density Lipoprotein in Mice

1997 • 44 citations

Developmental regulation of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (APOBEC-1) in human small intestine.

1995 • 44 citations

Cloning and sequence analysis of a human type A/B hnRNP protein

1991 • 43 citations

Apolipoprotein B mRNA editing: the sequence to the event

1993 • 40 citations

Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein(a) in Transgenic Mice and Induces Apolipoprotein B Editing in Rabbits

1996 • 40 citations

REPR and complementation factor(s) interact to modulate rat apolipoprotein B mRNA editing in response to alterations in cellular cholesterol flux.

1994 • 35 citations

Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide

1997 • 31 citations

Effective Lowering of Plasma, LDL, and Esterified Cholesterol in LDL Receptor–Knockout Mice by Adenovirus-Mediated Gene Delivery of ApoB mRNA Editing Enzyme (Apobec1)

1997 • 27 citations

Cloning and characterization of the rat apobec-1 gene: a comparative analysis of gene structure and promoter usage in rat and mouse

1997 • 22 citations

In vitro apolipoprotein B mRNA editing activity can be modulated by fasting and refeeding rats with a high carbohydrate diet

1992 • 17 citations

Use of somatic gene transfer to study lipoprotein metabolism in experimental animals in vivo

1995 • 17 citations

Increased proportion of plasma apoB-48 to apoB-100 in non-insulin-dependent diabetic rats: contribution of enhanced apoB mRNA editing in the liver.

1995 • 13 citations

Control of Apolipoprotein B mRNA Editing: Implications of mRNA Dynamics at Various Maturation Stages

1996 • 10 citations