The Regulation and Role of Epidermal Lipid Synthesis

Dermatology in General Medicine.

1987 • 4,066 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Permeability of the skin

1971 • 1,388 citations

Epidermal Lipids, Barrier Function, and Desquamation

1983 • 1,296 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Metabolic Control and Disease.

1980 • 570 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat

1983 • 414 citations

Transepidermal water loss: the signal for recovery of barrier structure and function.

1989 • 407 citations

Studies on Contact Sensitivity to Chromium in the Guinea Pig. The Role of Valence in the Formation of the Antigenic Determinant

1983 • 354 citations

Dermatology in General Medicine

1988 • 338 citations

Lipid content and lipid type as determinants of the epidermal permeability barrier.

1989 • 327 citations

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 • 309 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Lipid composition and metabolism in normal and diseased epidermis

1981 • 261 citations

Barrier function regulates epidermal DNA synthesis.

1991 • 252 citations

Glycolipids in Mammalian Epidermis: Structure and Function in the Water Barrier

1982 • 246 citations

Relationship of epidermal lipogenesis to cutaneous barrier function.

1987 • 245 citations

Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth

1984 • 235 citations

THE EXTRAHEPATIC SYNTHESIS OF CHOLESTEROL

1950 • 231 citations

Regulation of rates of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water.

1980 • 228 citations

The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition.

1978 • 215 citations

De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements.

1985 • 208 citations

Measurement of rates of cholesterol synthesis using tritiated water

1984 • 204 citations

Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants.

1977 • 195 citations

Cholesterol synthesis is required for cutaneous barrier function in mice.

1990 • 191 citations

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

1974 • 161 citations

Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates.

1979 • 160 citations

Sphingolipids of the Stratum Corneum and Lamellar Granules of Fetal Rat Epidemis

1984 • 150 citations

Limitations of Acetate as a Substrate for Measuring Cholesterol Synthesis in Liver

1974 • 144 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

1978 • 143 citations

Refsum's Disease: Nature of the Enzyme Defect

1967 • 134 citations

The Lovastatin-Treated Rodent: A New Model of Barrier Disruption and Epidermal Hyperplasia

1991 • 116 citations

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements.

1990 • 115 citations

Measurement of rate of rat liver sterol synthesis in vivo using tritiated water.

1977 • 114 citations

Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens.

1989 • 105 citations

LIPOGENESIS OF THE INTACT ALLOXAN-DIABETIC RAT

1954 • 100 citations

Reversible modulation of liver hydroxymethylglutaryl CoA reductase

1978 • 97 citations

Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton.

1977 • 90 citations

Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid

1984 • 90 citations

[34] Measurement of rates of lipogenesis with deuterated and tritiated water

1975 • 85 citations

Cultured Human Skin Fibroblasts and Keratinocytes: Differences in the Regulation of Cholesterol Synthesis

1983 • 84 citations

Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by .beta.-chloroalanine

1988 • 78 citations

Serine-palmitoyl transferase activity in cultured human keratinocytes

1990 • 77 citations

The Site of Sterol and Squalene Synthesis in the Human Skin123

1955 • 76 citations

Phosphorylation of Native 97-kDa 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase from Rat Liver

1989 • 70 citations

Effect of Essential Fatty Acid Deficiency on Cutaneous Sterol Synthesis

1986 • 69 citations

Cholesterogenesis: Derepression in Extrahepatic Tissues with 4-Aminopyrazolo [3,4- d ]pyrimidine

1976 • 68 citations

The Effect of Diabetes Mellitus on Sterol Synthesis in the Intact Rat

1982 • 67 citations

Effects of cholesterol sulfate on lipid metabolism in cultured human keratinocytes and fibroblasts

1987 • 65 citations

Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin

1988 • 64 citations

Localization of De Novo Sterologenesis in Mammalian Skin

1983 • 60 citations

Epidermal Metabolism in Heredopathia Atactica Polyneuritiformis (Refsum's Disease)

1978 • 57 citations

Dietary Supplementation with Oils Rich in (n-3) and (n-6) Fatty Acids Influences in Vivo Levels of Epidermal Lipoxygenase Products in Guinea Pigs

1990 • 56 citations

Localization of sites of lipid biosynthesis in mammalian epidermis.

1988 • 55 citations

Low Density Lipoprotein Receptor Expression on Keratinocytes in Normal and Psoriatic Epidermis

1987 • 55 citations

Inhibition of lipid synthesis and glucose-6-phosphate dehydrogenase in rat skin by dehydroepiandrosterone

1970 • 49 citations

Essential Fatty Acids and Polyunsaturated Fatty Acids: Significance in Cutaneous Biology

1990 • 48 citations

Cell Proliferation Kinetics of Epidermis in the Essential Fatty Acid Deficient Rat

1978 • 48 citations

Free fatty acid effects on leakage, phase properties and fusion of fully hydrated model membranes

1989 • 47 citations

De novo sterologenesis in the intact rat

1983 • 46 citations

Quantitative importance of different organs for cholesterol synthesis and low-density-lipoprotein degradation

1983 • 46 citations

Lipid‐Related Barriers and Gradients in the Epidermis^a

1988 • 43 citations

Relative contribution of the main tissues and organs to body fatty acid synthesis in the rat

1983 • 42 citations

Free sterol metabolism and low density lipoprotein receptor expression as differentiation markers of cultured human keratinocytes

1987 • 40 citations

Defective Low-Density Lipoprotein Metabolism in Cultured, Normal, Transformed, and Malignant Keratinocytes

1984 • 40 citations

THE EFFECT OF OCCULUSIVE AND SEMIUPERMEABLE DRESSINGS ON THE MITOTIC ACTRIVITY OF NORMAL AND WOUDED HUMAN EPIDERMIS

1972 • 35 citations

THE IN VITRO INCORPORATION OF 14C-ACETATE INTO THE ISOLATED SEBACEOUS GLANDS AND APPENDAGE-FREED EPIDERMIS OF HUMAN SKIN.

1971 • 34 citations

Abnormal Lipogenesis in Thyroid Hormone-Deficient Epidermis

1986 • 33 citations

Lipid Metabolism in the Diabetic Rat

1960 • 33 citations

Physical Occlusion Controlling Epidermal Mitosis

1972 • 32 citations

De novo sterologenesis in intact primates.

1982 • 30 citations

Altered activation state of hydroxymethylglutaryl-coenzyme A reductase in liver tumors

1983 • 25 citations

Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis

1971 • 24 citations

Lipogenesis in Human Skin11From the Department of Medicine, New England Center Hospital, and Tufts University School of Medicine, Boston 11, Massachusetts

1959 • 24 citations

EPIDERMAL CELL KINETICS IN PSORIASIS

1979 • 23 citations

Lipogenesis in rat skin: A possible regulatory role of glycerol 3-phosphate

1969 • 21 citations

Lipid Metabolism in Human Skin

1966 • 21 citations

Lipid Synthesis from Acetate-1-14C by Suction Blister Epidermis and Other Skin Components

1970 • 20 citations

Lipogenesis in Human Skin. III. Variation with Body Site

1963 • 19 citations

Specific sites of fatty acid and sterol synthesis in isolated skin components

1966 • 18 citations

Differences in de Novo Cholesterol Synthesis between the Intact Male and Female Rat *

1983 • 17 citations

LIPID SYNTHESIS IN RAT SKIN

1972 • 14 citations

Anaerobic Conversion of Acetate to Squalene by Rat Skin.

1961 • 11 citations

The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro

1987 • 8 citations

Some Factors Affecting C14-Acetate Incorporation into Polyunsaturated Fatty Acids of Skin

1973 • 5 citations

Studies of the Lipids of Dog Skin. IV

1968 • 5 citations

Effects of long-term tolbutamide therapy on severity of diabetes in partially depancreatized rats.

1960 • 4 citations