Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

1974 • 1,038 citations

Synthetic immunostimulants derived from the bacterial cell wall

1980 • 196 citations

Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components

1976 • 160 citations

Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.

1975 • 139 citations

Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds

1976 • 125 citations

Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

1974 • 108 citations

The comparative selectivity of adjuvants for humoral and cell-mediated immunity. I. Effect on the antibody response to bovine serum albumin and sheep red blood cells of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.

1980 • 98 citations

Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs

1980 • 95 citations

Stimulation of thymocyte mitogenic protein secretion and of cytostatic activity of mouse peritoneal macrophages by trehalose dimycolate and muramyl‐dipeptide

1980 • 70 citations

Peptides as requirement for immunotherapy of the guinea-pig line-10 tumor with endotoxins

1979 • 55 citations

Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate

1981 • 44 citations

Relationship between chemical structure and adjuvant activity of some synthetic analogues of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP).

1977 • 32 citations

Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil.

1979 • 28 citations