Construction of Synthetic Immunogen: Use of New T-Helper Epitope on Malaria Circumsporozoite Protein

Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum

1984 • 716 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

T-cell antigenic sites tend to be amphipathic structures.

1985 • 527 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

1980 • 439 citations

Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria

1985 • 371 citations

Lymphocyte specificity to protein antigens. I. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice.

1977 • 361 citations

Expression of Plasmodium falciparum Circumsporozoite Proteins in Escherichia coli for Potential Use in a Human Malaria Vaccine

1985 • 210 citations

Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine.

1986 • 181 citations

Lymphocyte Specificity to Protein Antigens

1977 • 175 citations

The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines.

1986 • 142 citations

Strong conformational propensities enhance T cell antigenicity.

1987 • 130 citations

Immunity to sporozoite-induced malaria infeciton in mice. I. The effect of immunization of T and B cell-deficient mice.

1977 • 109 citations

Constraints in T‐B cooperation related to epitope topology on E. coli β‐galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation‐ dependent determinants

1985 • 97 citations

An Ia-restricted epitope-specific circuit regulating T cell-B cell interaction and antibody specificity

1983 • 81 citations

Immunity to Sporozoite-Induced Malaria Infection in Mice

1977 • 76 citations

Structure of the circumsporozoite protein gene in 18 strains of Plasmodium falciparum

1985 • 71 citations