DNA Methylation Patterns: Formation and Biological Functions

DNA Methylation and Gene Function

1980 • 2,069 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

1982 • 1,002 citations

Sequence specificity of methylation in higher plant DNA

1981 • 719 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.

1982 • 575 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 442 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

The somatic replication of DNA methylation

1981 • 368 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression.

1980 • 309 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 281 citations

5-Methylcytosine localised in mammalian constitutive heterochromatin

1974 • 267 citations

Clonal inheritance of the pattern of DNA methylation in mouse cells.

1982 • 229 citations

The absence of detectable methylated bases in Drosophila melanogaster DNA

1982 • 211 citations

Variable patterns of total DNA and rDNA methylation in animals

1980 • 210 citations

Independent mechanisms involved in suppression of the moloney leukemia virus genome during differentiation of murine teratocarcinoma cells

1983 • 205 citations

Dna Methylation and its Possible Biological Roles

1981 • 202 citations

EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme.

1977 • 202 citations

Distribution of 5-methylcytosine in chromatin.

1977 • 196 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

Mechanism of action of eukaryotic DNA methyltransferase

1982 • 195 citations

Methylation of foreign DNA sequences in eukaryotic cells.

1980 • 190 citations

Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells

1981 • 190 citations

Direct detection of methylated cytosine in DNA by use of the restriction enzyme Mspl

1979 • 188 citations

Variations in DNA methylation during mouse cell differentiation in vivo and in vitro.

1984 • 187 citations

Expression of a cloned adenovirus gene is inhibited by in vitro methylation.

1982 • 184 citations

Pleiotropic effects of a DNA adenine methylation mutation (dam-3) in Escherichia coli K12

1975 • 183 citations

Unmethlated domains in vertebrate DNA

1983 • 173 citations

Pattern of methylation of two genes coding for housekeeping functions.

1983 • 148 citations

[6N]METHYL ADENINE IN THE NUCLEAR DNA OF A EUCARYOTE, TETRAHYMENA PYRIFORMIS

1973 • 145 citations

Studies on Sequence Recognition By Type II Restriction and Modification Enzyme

1982 • 120 citations

Loss of rDNA methylation accompanies the onset of ribosomal gene activity in early development of X. laevis

1981 • 116 citations

DNA methylase from HeLa cell nuclei

1975 • 114 citations

ESCHERICHIA COLI K-12*

1973 • 114 citations

The kinetics of DNA methylation in cultures of a mouse adrenal cell line

1970 • 112 citations

Modified bases in the DNAs of unicellular eukaryotes: an examination of distributions and possible roles, with emphasis on hydroxymethyluracil in dinoflagellates

1978 • 108 citations

Mouse nuclear satellite DNA: 5-methylcytosine content, pyrimidine isoplith distribution and electron microscopic appearance

1969 • 105 citations

Mechanism of action of rat liver DNA methylase

1971 • 103 citations

Restriction enzyme digestion of hemimethylated DNA

1981 • 101 citations

DNA-methylase from regenerating rat liver: purification and characterisation

1978 • 99 citations

Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

1983 • 98 citations

DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity.

1976 • 97 citations

5-methylcytosine is localized in nucleosomes that contain histone H1.

1983 • 97 citations

Organization of 5-methylcytosine in chromosomal DNA

1978 • 95 citations

Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells.

1982 • 88 citations

Mouse DNA methylase: Methylation of native DNA

1979 • 86 citations

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

1982 • 85 citations

Amplified ribosomal RNA genes in a rat hepatoma cell line are enriched in 5-methylcytosine.

1981 • 80 citations

Methylation of the bacterial chromosome: an event at the “replication point”?

1968 • 77 citations

Studies on the in vivo methylation of DNA in Escherichia coli 15T−

1968 • 77 citations

S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line

1975 • 73 citations

DNA methylation pattern is determined by the intracellular level of the methylase.

1984 • 72 citations

Methylated and unmethylated ribosomal RNA genes in the mouse

1981 • 71 citations

Methylation of replicating and post-replicated mouse L-cell DNA.

1983 • 70 citations

Distribution of 5-methylcytosine in the DNA of somatic and germline cells from bovine tissues

1981 • 66 citations

Isolation and characterisation of DNA cytosine 5-methyltransferase from human placenta

1983 • 65 citations

Kinetics of Methylation of DNA by a Restriction Endonuclease from Escherichia coli B

1974 • 64 citations

The 5‐methylcytosine content of DNA: Tissue specificity

1971 • 59 citations

Studies on the biological role of DNA methylation; IV. Mode of methylation of DNA in E. coli cells

1980 • 58 citations

Variable methylation of the ribosomal RNA genes of the rat

1982 • 58 citations

The relationship between synthesis and methylation of DNA in mouse fibroblasts

1971 • 55 citations

Inheritance of DNA methylation in microinjected eggs of Xenopus laevis.

1982 • 55 citations

Nucleotide clusters in deoxyribonucleic acids

1969 • 55 citations

Mechanism of action of rat liver DNA methylase

1971 • 47 citations

Nucleotide clusters in deoxyribonucleic acids XII. The distribution of 5-methylcytosine in pyrimidine oligonucleotides of mouse L-cell satellite DNA and main band DNA

1975 • 46 citations

Sequence and substrate specificity of isolated DNA methylases from Escherichia coli C

1983 • 44 citations

Effect of DNA Methylation on Gene Expression

1983 • 39 citations

Studies on the biological role of DNA methylation: V. The pattern ofE.coliDNA methylation

1982 • 37 citations

Effect of several inhibitors of enzymatic DNA methylation on thein vivomethylation of different classes of DNA sequences in a cultured human cell line

1983 • 36 citations

Shope papilloma virus DNA is extensively methylated in non-virus-producing neoplasms

1983 • 35 citations

Restriction Endonuclease B and f1 Heteroduplex DNA

1973 • 34 citations

Topographical Distribution of 5-Methylcytosine in Animal and Plant DNA

1982 • 22 citations

Sequence organisation in nuclear DNA from Physarum polycephalum: methylation of repetitive sequences

1981 • 22 citations

Methylation of Mouse Ribosomal RNA Genes

1982 • 17 citations

DNA methylation patterns in the 5S DNAs ofXenopus laevis

1983 • 15 citations

Effect ofin vitromethylation at CpG sites on gene expression in a genome functioning autonomously in a vertebrate host

1982 • 14 citations

Intracellular epstein-barr virus DNA is methylated in and around the EcoRI-J fragment in both producer and nonproducer cell lines

1983 • 13 citations

Topographical distribution of 5-methylcytosine in animal and plant DNA.

1982 • 11 citations

Nucleic acids methylation of synchronized BHK 21 HS 5 fibroblasts during the mitotic phase

1980 • 10 citations