Studies on Sequence Recognition By Type II Restriction and Modification Enzyme

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Personal Communication

1997 • 2,763 citations

Nucleotide sequence of bacteriophage G4 DNA

1978 • 2,137 citations

Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis

1973 • 1,616 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

E. coli RNA polymerase interacts homologously with two different promoters

1980 • 911 citations

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1981 • 873 citations

A Restriction enzyme from Hemophilus influenzae

1970 • 859 citations

Crystal structure analysis of a complete turn of B-DNA

1980 • 844 citations

DNA Restriction Enzyme from E. coli

1968 • 816 citations

Studies on the cleavage of bacteriophage lambda DNA with EcoRI restriction endonuclease

1975 • 798 citations

Lac represser-operator interaction

1973 • 699 citations

The nucleotide sequence of bacteriophage φX174

1978 • 689 citations

A restriction enzyme from Hemophilus influenzae

1970 • 592 citations

Cruciform structures in supercoiled DNA

1981 • 545 citations

Genetic Regulation: The Lac Control Region

1975 • 523 citations

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.

1980 • 519 citations

Helical repeat of DNA in solution.

1979 • 481 citations

A Suggested nomenclature for bacterial host modification and restriction systems and their enzymes

1973 • 457 citations

A restriction enzyme from Hemophilus influenzae: II. Base sequence of the recognition site

1970 • 455 citations

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

DNA-Protein Interactions

1972 • 412 citations

Restriction Endonuclease

1976 • 405 citations

Isolation of Deoxyribonucleic Acid Methylase Mutants of Escherichia coli K-12

1973 • 372 citations

Complementary specificity of restriction endonucleases of Diplococcus pneumoniae with respect to DNA methylation

1977 • 369 citations

DNA Nucleotide Sequence Restricted by the RI Endonuclease

1972 • 365 citations

Diffusion controlled reaction rates in spheroidal geometry

1974 • 344 citations

Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.

1979 • 339 citations

DNA Restriction and Modification Mechanisms in Bacteria

1971 • 324 citations

Restriction and modification enzymes and their recognition sequences

1981 • 317 citations

Specificity of substrate recognition by the EcoRI restriction endonuclease.

1975 • 313 citations

lac represser binding to non-operator DNA: Detailed studies and a comparison of equilibrium and rate competition methods

1972 • 304 citations

Isolation of a sequence-specific endonuclease (BamI) from Bacillus amyloliquefaciens H

1975 • 301 citations

How many base-pairs per turn does DNA have in solution and in chromatin? Some theoretical calculations.

1978 • 286 citations

EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme.

1976 • 259 citations

Manipulation of restriction targets in phage λ to form receptor chromosomes for DNA fragments

1974 • 253 citations

Viable Molecular Hybrids of Bacteriophage Lambda and Eukaryotic DNA

1974 • 250 citations

Specificity of<u>Hpa</u>II and<u>Hae</u>II DNA methylases

1977 • 221 citations

Specific Fragments of φX174 Deoxyribonucleic Acid Produced by a Restriction Enzyme from Haemophilus aegyptius , Endonuclease Z

1972 • 213 citations

EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme.

1977 • 202 citations

Structure and Mechanism of Multifunctional Restriction Endonucleases

1981 • 201 citations

DNA Structure and Gene Regulation

1980 • 200 citations

Model for DNA and Protein Interactions and the Function of the Operator

1966 • 197 citations

Transient electric dichroism of rod-like DNA molecules.

1978 • 195 citations

Sequence analysis of the DNA encoding the Eco RI endonuclease and methylase.

1981 • 194 citations

A deoxyribonuclease of Diplococcus pneumoniae specific for methylated DNA

1975 • 192 citations

Recognition sequence of restriction endonuclease III from Hemophilus influenzae

1975 • 173 citations

DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes.

1981 • 167 citations

Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate

1975 • 164 citations

Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form.

1968 • 160 citations

Specificity of different classes of ethylating agents toward various sites of HeLa cell DNA in vitro and in vivo

1975 • 159 citations

Measurements of unwinding of lac operator by repressor

1974 • 158 citations

Mutagenesis of plasmid DNA with hydroxylamine: Isolation of mutants of multi-copy plasmids

1976 • 151 citations

Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level.

1978 • 150 citations

Models of specifically paired like (homologous) nucleic acid structures

1971 • 145 citations

A specific endonuclease from Haemophilus haemolyticus

1976 • 145 citations

Altering the specificity of restriction endonuclease: effect of replacing Mg²⁺ with Mn²⁺

1978 • 135 citations

‘Single-stranded’ DNA from φX174 and M13 is cleaved by certain restriction endonucleases

1975 • 134 citations

Molecular Mechanism for Genetic Recombination

1972 • 133 citations

Two sequence-specific endonucleases from Moraxella bovis

1977 • 132 citations

Nucleotide sequences at the cleavage sites of two restriction endonucleases from Hemophilus parainfluenzae

1974 • 127 citations

Recognition Sequence of a Restriction Enzyme

1973 • 125 citations

Two restriction endonucleases from Bacillus globiggi

1976 • 119 citations

Physical identity of the SV40 deoxyribonucleic acid sequence recognized by the Eco RI restriction endonuclease and modification methylase

1974 • 118 citations

Structures and mechanisms of DNA restriction and modification enzymes

1979 • 116 citations

Recognition sequence of specific endonuclease BamHI from Bacillus amyloliquefaciens H

1977 • 111 citations

Complementary action of restriction enzymes endo R · DpnI and endo R · DpnII on bacteriophage f1 DNA

1977 • 109 citations

DNA determinants important in sequence recognition by Eco RI endonuclease.

1981 • 107 citations

A restriction endonuclease from Staphylococcus aureus

1976 • 101 citations

Novel properties of a restriction endonuclease isolated from Haemophilus parahaemolyticus.

1976 • 99 citations

R Factor-Controlled Restriction and Modification of Deoxyribonucleic Acid: Restriction Mutants

1972 • 96 citations

Restriction and modification in B. subtilis

1975 • 93 citations

EcoRI cleavage and methylation of DNAs containing modified pyrimidines in the recogintion sequence.

1977 • 86 citations

Restriction and modification in B. subtilis

1975 • 85 citations

DNA methylases of Hemophilus influenzae Rd

1973 • 85 citations

Duplex regions in "single-stranded" phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius.

1977 • 85 citations

Restriction and modification enzymes and their recognition sequences

1980 • 84 citations

DNA methylases of Hemophilus influenzae Rd

1973 • 78 citations

Cleavage of Nonglucosylated Bacteriophage T4 deoxyribonucleic acid by Restriction Endonuclease Eco RI.

1975 • 77 citations

DNA site recognition and reduced specificity of the Eco RI endonuclease.

1980 • 76 citations

Site-specific cleavage of single-stranded DNA by a Hemophilus restriction endonuclease.

1975 • 72 citations

The EcoRI restriction endonuclease with bacteriophage λ DNA. Equilibrium binding studies

1980 • 71 citations

Alteration of the specificity of restriction endonucle, ases in the presence of organic solvents

1980 • 71 citations

Recognition Mechanisms of DNA-Specific Enzymes

1976 • 69 citations

Kinetic studies on the cleavage of adenovirus DNA by restriction endonuclease Eco RI

1976 • 68 citations

The EcoRI restriction endonuclease with bacteriophage λ DNA. Kinetic studies

1980 • 67 citations

Substrate dependence of the mechanism of EcoRI endonuclease

1978 • 65 citations

Kinetics of Methylation of DNA by a Restriction Endonuclease from Escherichia coli B

1974 • 64 citations

Sequence specificity of DNA methylases from Bacillus amyloliquefaciens and Bacillus brevis

1978 • 63 citations

The specific non-symmetrical sequence recognized by restriction endonuclease MboII

1980 • 62 citations

The Interaction of the EcoRI Restriction Endonuclease with its Substrate

1980 • 61 citations

A specific endonuclease from Bacillus caldolyticus

1978 • 60 citations

The effects of substituted pyrimidines in DNAs on cleavage by sequence-specific endonucleases

1979 • 59 citations

Role of the 2-amino group of deoxyguanosine in sequence recognition by EcoRI restriction and modification enzymes.

1977 • 59 citations

Sequence-specific endonuclease Bam HI. Effect of hydrophobic reagents on sequence recognition and catalysis.

1980 • 52 citations

The reactions of the EcoRi and other restriction endonucleases

1979 • 52 citations

On the Molecular Bases of the Specificity of Interaction of Transcriptional Proteins with Genome DNA

1979 • 51 citations

A new sequence-specific endonuclease (Bsp) from Bacillus sphaericus

1977 • 51 citations

Biochemical Characterization of the Restriction‐Modification System of Bacillus sphaericus

1978 • 49 citations

Single-strand and double-strand cleavage at half-modified and fully modified recognition sites for the restriction nucleases Sau3A and TaqI

1980 • 48 citations

Cleavage specificity of the restriction endonuclease isolated from Haemophilus gallinarum (Hga I).

1977 • 47 citations

Isolation and properties of a thermostable restriction endonuclease (ENDO R-Bst1503)

1977 • 47 citations

Purification and characterization of the sequence-specific endonuclease Bam HI.

1979 • 46 citations

Purification, properties and specificity of the restriction endonuclease from Bacillus stearothermophilus

1979 • 45 citations

A catalogue of cleavages of ∅X174, S13, G4, and ST-1 DNA by 26 different restriction endonucleases

1976 • 45 citations

Specificity of cleavage by a restriction nuclease from Bacillus subtilis

1977 • 45 citations

Non-specific binding of restriction endonudease EcoR1 to DNA

1980 • 42 citations

Intermediates in genetic recombination of bacteriophage T7 DNA. Biological activity and the roles of gene 3 and gene 5

1978 • 42 citations

EcoRI★ activity: Enzyme modification or activation of accompanying endonuclease?

1978 • 42 citations

Cleavage of DNA.RNA hybrids by Type II restriction enzymes

1980 • 41 citations

Digestion of 5-bromodeoxyuridine-substituted lambda-DNA by restriction endonucleases.

1978 • 41 citations

Relaxed circular SV40 DNA as cleavage intermediate of two restriction endonucleases

1977 • 39 citations

Isolation and characterization of two proteins possessing Hpa II methylase activity.

1980 • 37 citations

Inhibition of Eco RI action by polynucleotides. A characterization of the non-specific binding of the enzyme to DNA

1980 • 36 citations

Rate enhancement by guided diffusion. Chain length dependence of repressor-operator association rates

1978 • 34 citations

Recognition sequence of a restriction endonuclease from Haemophilus gallinarum

1978 • 32 citations

Use of short synthetic DNA duplexes as substrates for the restriction endonucleases Hpa II and Mno I.

1979 • 29 citations

DNA site recognition and overmethylation by the Eco RI methylase.

1980 • 28 citations

[17] Purification and properties of the complementary endonucleases DpnI and DpnII

1980 • 28 citations

Cleavage of single strand oligonucleotides and bacteriophage phi X174 DNA by Msp I endonuclease.

1980 • 27 citations

A DNA sequence cleaved by restriction endonuclease R.EcoRI in only one strand

1979 • 27 citations

Preliminary X-ray diffraction studies of EcoRI restriction endonuclease-DNA complex

1981 • 24 citations

Tertiary structure for palindromic regions of DNA

1978 • 23 citations

The DNA sequence recognised by

1980 • 23 citations

[12] Purification and properties of EcoRI endonuclease

1980 • 22 citations

Preliminary X-ray diffraction analysis of crystalline EcoRI endonuclease

1978 • 22 citations

[15] Purification and properties of the Bsu endonuclease

1980 • 21 citations

The recognition site of type II restriction enzyme BglI is interrupted

1980 • 20 citations

Sequence-specific endonuclease Bgl I. Modification of lysine and arginine residues of the homogeneous enzyme.

1979 • 19 citations

Four-stranded DNA structure and DNA base methylation in the mechanism of action of restriction endonucleases

1979 • 18 citations

Recognition sequence for the restriction endonuclease BglI from Bacillus globigii

1980 • 18 citations

Plasmid cloning vectors that can be nicked at a unique site

1980 • 17 citations

Overmethylation of DNAs by the EcoRI methylase

1978 • 16 citations

The structure and function of the Eco RI restriction endonuclease.

1981 • 15 citations

Partial NH2- and cooh-terminal sequence analyses of Eco RI DNA restriction and modification enzymes.

1981 • 12 citations

Restriction Endonucleases and Modification Methylases in Bacteria

1978 • 11 citations

[16] Purification and properties of the Bg1I and II endonucleases

1980 • 8 citations

Structures and mechanisms of Eco RI DNA restriction and modification enzymes.

1981 • 3 citations