Endothelial Gene Regulation by Laminar Shear Stress

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

1985 • 2,605 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Atheroma and arterial wall shear - Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis

1971 • 1,340 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.

1994 • 576 citations

Hemodynamic forces are complex regulators of endothelial gene expression

1995 • 547 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.

1994 • 389 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

1995 • 343 citations

Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1

1995 • 301 citations

Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.

1995 • 276 citations

Regulation of the tissue factor gene

1995 • 275 citations

Stimulation of Transcription Factors NFκB and AP1 in Endothelial Cells Subjected to Shear Stress

1994 • 271 citations

Shear stress increases endothelial platelet-derived growth factor mRNA levels

1991 • 208 citations

Apparatus for subjecting living cells to fluid shear stress

1982 • 174 citations

Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.

1994 • 159 citations

Physical forces and the mammalian cell

1993 • 158 citations

Disruption of cytoskeletal structures mediates shear stress-induced endothelin-1 gene expression in cultured porcine aortic endothelial cells.

1993 • 119 citations

Pulsatile flow and atherosclerosis in the human carotid bifurcation: Positive correlation between plaque location and low and oscillating shear stress

1986 • 105 citations

Endothelial gene regulation by biomechanical forces

1994 • 7 citations