Brain Mapping: The Applications

Diagnostic and Statistical Manual of Mental Disorders

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The expression of the emotions in man and animals.

1872 • 11,160 citations

The Attention System of the Human Brain

1990 • 7,582 citations

Feeling and thinking: Preferences need no inferences.

1980 • 7,533 citations

Cognitive, social, and physiological determinants of emotional state.

1962 • 5,942 citations

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

1992 • 5,156 citations

Pictures of Facial Affect

1976 • 4,335 citations

The Emotional Brain

1996 • 3,578 citations

A PROPOSED MECHANISM OF EMOTION

1937 • 3,511 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Contributions of anterior cingulate cortex to behaviour

1995 • 3,315 citations

Looking at pictures: Affective, facial, visceral, and behavioral reactions

1993 • 3,096 citations

II.—WHAT IS AN EMOTION ?

1884 • 3,055 citations

Automatic and effortful processes in memory.

1979 • 2,718 citations

Large‐scale neurocognitive networks and distributed processing for attention, language, and memory

1990 • 2,670 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

The somatic marker hypothesis and the possible functions of the prefrontal cortex

1996 • 2,603 citations

Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.

1990 • 2,437 citations

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

1999 • 2,351 citations

Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala

1994 • 2,309 citations

What is an emotion

1977 • 2,254 citations

The Role of the Amygdala in Fear and Anxiety

1992 • 2,216 citations

Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge

1998 • 2,215 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

The frontal lobes

1986 • 2,138 citations

A differential neural response in the human amygdala to fearful and happy facial expressions

1996 • 2,015 citations

Chapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions

1991 • 1,897 citations

Circuitry and functional aspects of the insular lobe in primates including humans

1996 • 1,750 citations

Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression

1996 • 1,718 citations

Affect and memory: A review.

1986 • 1,676 citations

Pan-Cultural Elements in Facial Displays of Emotion

1969 • 1,666 citations

A specific neural substrate for perceiving facial expressions of disgust

1997 • 1,616 citations

Neurotransmitters and neuromodulators in the basal ganglia

1990 • 1,578 citations

Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear

1988 • 1,573 citations

MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder

1995 • 1,567 citations

A PET study of visuospatial attention

1993 • 1,542 citations

Limbic-cortical dysregulation: a proposed model of depression

1997 • 1,542 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Sleep and Psychiatric Disorders

1992 • 1,437 citations

Cognition and motivation in emotion.

1991 • 1,362 citations

Reduction of Prefrontal Cortex Glucose Metabolism Common to Three Types of Depression

1989 • 1,306 citations

Localization of a human system for sustained attention by positron emission tomography

1991 • 1,294 citations

Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder

1992 • 1,283 citations

Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat

1978 • 1,282 citations

A functional anatomical study of unipolar depression

1992 • 1,266 citations

Acute Effects of Cocaine on Human Brain Activity and Emotion

1997 • 1,263 citations

Neurological Anatomy. In Relation to Clinical Medicine.

1970 • 1,250 citations

Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

1995 • 1,216 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

Psychosomatic Disease and the "Visceral Brain"

1949 • 1,163 citations

Cognition and motivation in emotion.

1991 • 1,162 citations

Projections to the frontal cortex from the posterior parietal region in the rhesus monkey

1984 • 1,120 citations

The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress

1993 • 1,118 citations

Depression and Parkinson's disease: a review

1992 • 1,110 citations

Hippocampal damage associated with prolonged glucocorticoid exposure in primates

1990 • 1,092 citations

Cortico-cortical connections in the rhesus monkey

1969 • 1,086 citations

MOOD DISORDERS IN STROKE PATIENTS: IMPORTANCE OF LOCATION OF LESION

1984 • 1,079 citations

Crouching as an index of fear.

1969 • 1,057 citations

Selective averaging of rapidly presented individual trials using fMRI

1997 • 1,041 citations

Cingulate function in depression

1997 • 1,034 citations

A Symptom Provocation Study of Posttraumatic Stress Disorder Using Positron Emission Tomography and Script-Driven Imagery

1996 • 1,016 citations

Neurological anatomy in relation to clinical medicine

1982 • 1,013 citations

Emotional Behavior and Hemispheric Side of the Lesion

1972 • 979 citations

Multiple Representations of Pain in Human Cerebral Cortex

1991 • 971 citations

Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man

1971 • 946 citations

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

The problem of the frontal lobe: A reinterpretation

1971 • 892 citations

Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat

1978 • 872 citations

The `subcortical dementia' of progressive supranuclear palsy

1974 • 872 citations

The Cognitive Neurosciences

1996 • 869 citations

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

1984 • 866 citations

Cingulate cortex of the rhesus monkey: II. Cortical afferents

1987 • 859 citations

Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study

1993 • 844 citations

Facial shape and judgements of female attractiveness

1994 • 832 citations

Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli

1996 • 826 citations

The Triune Brain in Evolution: Role in Paleocerebral Functions

1990 • 818 citations

Investigations of the functional anatomy of attention using the stroop test

1993 • 813 citations

Distributed processing of pain and vibration by the human brain

1994 • 807 citations

Psychosis and Temporal Lobe Epilepsy; A Controlled Investigation

1969 • 796 citations

Emotion, olfaction, and the human amygdala: Amygdala activation during aversive olfactory stimulation

1997 • 782 citations

Four systems for emotion activation: Cognitive and noncognitive processes.

1993 • 774 citations

The orbitofrontal cortex

1996 • 762 citations

Neuroanatomical correlates of happiness, sadness, and disgust

1997 • 758 citations

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

1990 • 754 citations

Hippocampal damage associated with prolonged and fatal stress in primates

1989 • 746 citations

Brain activity during transient sadness and happiness in healthy women

1995 • 743 citations

Innate and conditioned reactions to threat in rats with amygdaloid lesions.

1972 • 739 citations

Human cingulate cortex: Surface features, flat maps, and cytoarchitecture

1995 • 735 citations

The anatomy of melancholia – focal abnormalities of cerebral blood flow in major depression

1992 • 718 citations

Neuroanatomical correlates of externally and internally generated human emotion

1997 • 718 citations

Selective Retention of Corticosterone by Limbic Structures in Rat Brain

1968 • 700 citations

Cognitive processes in depression

1988 • 699 citations

An autoradiographic study of the projections of the central nucleus of the monkey amygdala

1981 • 694 citations

Systematic Changes in Cerebral Glucose Metabolic Rate After Successful Behavior Modification Treatment of Obsessive-Compulsive Disorder

1996 • 691 citations

Event-related f MRI

1997 • 691 citations

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

1987 • 682 citations

Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey

1994 • 656 citations

Relationship between subjective effects of cocaine and dopamine transporter occupancy

1997 • 653 citations

Lactate Metabolism in Anxiety Neurosis

1967 • 653 citations

Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain

1982 • 651 citations

Hemispheric Asymmetry in the Expression of Positive and Negative Emotions

1982 • 647 citations

The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction

1992 • 643 citations

Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food

1978 • 643 citations

Visual Mental Imagery Activates Topographically Organized Visual Cortex: PET Investigations

1993 • 637 citations

The psychopathic individual: A lack of responsiveness to distress cues?

1997 • 620 citations

The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis

1990 • 614 citations

Noradrenergic Function in Panic Anxiety

1984 • 602 citations

Differential diagnosis and classification of apathy

1990 • 590 citations

Amygdala central nucleus lesions: Effect on heart rate conditioning in the rabbit

1979 • 589 citations

Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear.

1993 • 580 citations

Mood Improvement Following Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients With Depression: A Placebo-Controlled Crossover Trial

1997 • 568 citations

Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys

1996 • 566 citations

Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey

1992 • 550 citations

Cortical and subcortical localization of response to pain in man using positron emission tomography

1991 • 545 citations

Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions

1993 • 530 citations

Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate body in the rat

1985 • 526 citations

Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli

1984 • 507 citations

THE DUALITY OF THE CINGULATE GYRUS IN MONKEY

1980 • 504 citations

Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys

1981 • 494 citations

Depression in Parkinson??s Disease

1990 • 490 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Left prefrontal glucose hypometabolism in the depressed state: a confirmation

1990 • 468 citations

Principles of Behavioral Neurology

1986 • 462 citations

Quantitative Cerebral Anatomy in Depression

1993 • 458 citations

5-HT_2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex

1997 • 448 citations

Equipotentiality of thalamo-amygdala and thalamo-cortico-amygdala circuits in auditory fear conditioning

1992 • 447 citations

Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.

1989 • 435 citations

Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus

1982 • 432 citations

A Trial-Based Experimental Design for fMRI

1997 • 429 citations

Further observations on corticofrontal connections in the rhesus monkey

1976 • 424 citations

Depression in Epilepsy

1986 • 421 citations

OBSESSIVE-COMPULSIVE AND OTHER BEHAVIOURAL CHANGES WITH BILATERAL BASAL GANGLIA LESIONS

1989 • 421 citations

COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS

1987 • 420 citations

A Theory of Emotion, and its Application to Understanding the Neural Basis of Emotion

1990 • 419 citations

On the induction of mood

1990 • 415 citations

Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease

1990 • 415 citations

Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims

1990 • 411 citations

Efferents and afferents of the ventral tegmental-A10 region studied after local injection of [3H]leucine and horseradish peroxidase

1979 • 405 citations

Synopsis of Psychiatry: Behavioral Sciences, Clinical Psychiatry

1992 • 400 citations

Neurobehavioral changes associated with caudate lesions

1989 • 396 citations

Differential Behavioral and Biochemical Effects of Right and Left Hemispheric Cerebral Infarction in the Rat

1979 • 394 citations

Information Cascade from Primary Auditory Cortex to the Amygdala: Corticocortical and Corticoamygdaloid Projections of Temporal Cortex in the Rat

1993 • 394 citations

The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation

1997 • 387 citations

The amygdalostriatal projections in the monkey. An anterograde tracing study

1985 • 387 citations

Responses to reward in monkey dorsal and ventral striatum

1991 • 382 citations

Effort and Cognition in Depression

1982 • 377 citations

Neurobiology of cingulate cortex and limbic thalamus : a comprehensive handbook

1993 • 377 citations

Paralimbic hypoperfusion in unipolar depression.

1994 • 372 citations

Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness

1986 • 371 citations

Anatomic basis of cognitive-emotional interactions in the primate prefrontal cortex

1995 • 364 citations

The flinders sensitive line rats: A genetic animal model of depression

1993 • 363 citations

Changes in regional cerebral blood flow on recovery from depression

1995 • 349 citations

Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression

1996 • 341 citations

Behavior and physiology of social stress and depression in female cynomolgus monkeys

1997 • 336 citations

Validation criteria for animal models of human mental disorders: Learned helplessness as a paradigm case

1986 • 333 citations

Conditioned fear assessed by freezing and by the suppression of three different baselines

1980 • 333 citations

Neural correlates of self-induced dysphoria

1993 • 329 citations

Animal models as simulations of depression

1991 • 328 citations

Neuroanatomical Correlates of a Lactate-Induced Anxiety Attack

1989 • 326 citations

Psychiatric Aspects of Neurological Disease

1976 • 323 citations

Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers

1989 • 322 citations

A focal brain abnormality in panic disorder, a severe form of anxiety

1984 • 321 citations

Chapter 7 Prefrontal cortical control of the autonomic nervous system: Anatomical and physiological observations

1991 • 311 citations

Effect of sertraline on regional metabolic rate in patients with affective disorder

1997 • 310 citations

Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain

1990 • 308 citations

Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography

1997 • 308 citations

Surgical Approaches in Psychiatry

1974 • 307 citations

Prefrontal cortex dysfunction in clinical depression

1994 • 306 citations

A Positron Emission Tomographic Study of Simple Phobic Symptom Provocation

1995 • 304 citations

Personality changes with frontal and temporal lobe lesions

1975 • 302 citations

Predictors of Relapse in Major Depressive Disorder

1983 • 301 citations

The application of positron emission tomography to the study of panic disorder

1986 • 295 citations

Effect of sleep deprivation on brain metabolism of depressed patients

1992 • 291 citations

Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder

1997 • 291 citations

Primate cingulostriatal projection: Limbic striatal versus sensorimotor striatal input

1994 • 286 citations

THE STRUCTURE OF EMOTIONS REFLECTED IN EPILEPTIC EXPERIENCES

1956 • 283 citations

Frontal lobe dysfunction in secondary depression

1994 • 281 citations

Comparison of prefrontal architecture and connections

1996 • 281 citations

Mirth, laughter and gelastic seizures

1993 • 279 citations

Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment

1997 • 279 citations

Diagnosis and Neuroanatomical Correlates of Depression in Brain-Damaged Patients

1981 • 277 citations

Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse

1997 • 275 citations

The afferent connections of the substantia innominata in the monkey,Macaca fascicularis

1985 • 272 citations

Connections of the Monkey Cingulate Cortex

1993 • 272 citations

Neural mechanisms in disorders of movement

1989 • 270 citations

Affective neuroscience: the emergence of a discipline

1995 • 269 citations

Neuropharmacology of Serotonin

1989 • 268 citations

Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity?

1993 • 265 citations

Regional Cerebral Blood Flow in Mood Disorders, III

1994 • 261 citations

Neuroanatomical Correlates of Anticipatory Anxiety

1989 • 259 citations

Phenomenology of Depression in Epilepsy

1987 • 256 citations

The Limbic System: Functional Organization and Clinical Disorders

1987 • 256 citations

Pimozide Blocks Establishment But Not Expression of Amphetamine-Produced Environment-Specific Conditioning

1983 • 256 citations

Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)

1997 • 256 citations

Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.

1991 • 251 citations

Regional brain activity when selecting a response despite interference: An H₂¹⁵O PET study of the stroop and an emotional stroop

1994 • 250 citations

Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment.

1992 • 250 citations

Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex

1997 • 250 citations

Abnormalities of Striatal Projection Neurons andN-Methyl-D-Aspartate Receptors in Presymptomatic Huntington's Disease

1990 • 244 citations

Major Depression in Primary Dementia

1988 • 241 citations

Anatomie comparée des circonvolutions cérébrales : le grand lobe limbique et la scissure limbique dans la série des mammifères

1878 • 241 citations

Architecture of Connectivity Within a Cingulo-Fronto-Parietal Neurocognitive Network for Directed Attention

1993 • 237 citations

The interaction between mood and cognitive function studied with PET

1997 • 235 citations

POSTSTROKE DEPRESSION AND LESION LOCATION

1986 • 235 citations

Magnetic Resonance Imaging and Mood Disorders

1995 • 232 citations

Gender differences in regional cerebral blood flow during transient self-induced sadness or happiness

1996 • 231 citations

Pattern of recurrence of illness after recovery from an episode of major depression: a prospective study

1992 • 230 citations

Brain regions involved in recognizing facial emotion or identity: an oxygen-15 PET study

1993 • 229 citations

MOTILITY, BEHAVIOR AND THE BRAIN*

1948 • 229 citations

Neuroanatomical circuits in depression: implications for treatment mechanisms.

1992 • 227 citations

PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression

1988 • 226 citations

Depression in Parkinson's Disease

1994 • 223 citations

The association of affective disorder with Huntington's Disease in a case series and in families

1983 • 223 citations

Mania after brain injury: Neuroradiological and metabolic findings

1990 • 221 citations

Wilson's Disease

1989 • 221 citations

BRADYPHRENIA IN PARKINSON'S DISEASE AND PSYCHOMOTOR RETARDATION IN DEPRESSIVE ILLNESS

1987 • 220 citations

The application of positron emission tomography to the study of normal and pathologic emotions.

1997 • 219 citations

Autonomic and somatomotor effects of amygdala central N. stimulation in awake rabbits☆

1983 • 207 citations

Associative retuning in the thalamic source of input to the amygdala and auditory cortex: Receptive field plasticity in the medial division of the medial geniculate body.

1992 • 206 citations

Cerebral Metabolism and Depression in Patients With Complex Partial Seizures

1992 • 204 citations

PET in generalized anxiety disorder

1991 • 204 citations

Effortful and Automatic Cognitive Processes in Depression

1986 • 204 citations

Functional neuroanatomy of visually elicited simple phobic fear: Additional data and theoretical analysis

1995 • 199 citations

Paralimbic frontal lobe hypometabolism in depression associated with Huntington's disease

1992 • 197 citations

The neurobiology of emotional experience

1997 • 195 citations

Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy

1994 • 194 citations

Depression, Anxiety, and Temporal Lobe Epilepsy

1990 • 194 citations

Mood effects on limbic blood flow correlate with emotional self-rating: A PET study with oxygen-15 labeled water

1995 • 193 citations

Retinotopic organization of early visual spatial attention effects as revealed by PET and ERPs

1997 • 190 citations

Differential neural response to positive and negative feedback in planning and guessing tasks

1997 • 189 citations

THE EFFECTS OF LATERALIZED FRONTAL LESIONS ON MOOD REGULATION

1986 • 189 citations

Psychosis and temporal lobe epilepsy

1966 • 186 citations

Cerebral correlates of depressed behavior in rats, visualized using 14C- 2-deoxyglucose autoradiography

1988 • 184 citations

The Association of Ventral Tegmental Area Histopathology With Adult Dementia

1988 • 183 citations

The dopamine synapse and the notion of ‘pleasure centers’ in the brain

1980 • 173 citations

Regionally selective increases in μ opioid receptor density in the brains of suicide victims

1990 • 171 citations

Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers

1995 • 170 citations

The role of the cingulate gyrus in depression: From functional anatomy to neurochemistry

1996 • 166 citations

Epidermal nevus syndrome

1991 • 165 citations

Cerebral glucose metabolic differences in patients with panic disorder.

1990 • 164 citations

In search of an emotional system in the brain: Leaping from fear to emotion and consciousness.

1995 • 160 citations

Neural responses to salient visual stimuli

1997 • 160 citations

Reduction of Cerebral Blood Flow in Older Depressed Patients

1994 • 159 citations

Associative retuning in the thalamic source of input to the amygdala and auditory cortex: Receptive field plasticity in the medial division of the medial geniculate body.

1992 • 158 citations

Social and Emotional Self‐Regulationa

1995 • 157 citations

The role of amygdaloid central nucleus in the retention of differential pavlovian conditioning of bradycardia in rabbits

1986 • 157 citations

Effects of the availability of rewarding septal and hypothalamic stimulation on bar pressing for food under conditions of deprivation.

1965 • 154 citations

Glucose utilization in the temporal cortex of affectively ill patients: Positron emission tomography

1987 • 153 citations

PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects

1997 • 151 citations

Temporal Lobe Involvement in Multiple Sclerosis Patients With Psychiatric Disorders

1987 • 150 citations

Multiple unit activity recorded from amygdala central nucleus during Pavlovian heart rate conditioning in rabbit

1982 • 150 citations

Induced depression in monkeys

1974 • 150 citations

Depression in Parkinson's disease: a biochemical and organic viewpoint.

1995 • 147 citations

Regional cerebral blood flow in mood disorders

1997 • 143 citations

The relationship of serotonin to depression in Parkinson's disease

1988 • 142 citations

Brain Imaging Abnormalities in Mental Disorders of Late Life

1990 • 142 citations

The Neurobiological Substrates of Depression in Parkinson’s Disease: A Hypothesis

1984 • 141 citations

Stressor-induced anhedonia in the mesocorticolimbic system

1991 • 139 citations

Abnormal speech articulation, psychomotor retardation, and subcortical dysfunction in major depression

1993 • 137 citations

Cognitive function in depression: its relationship to the presence and severity of intellectual decline

1994 • 134 citations

Update on the dementia spectrum of depression

1992 • 133 citations

Molecular basis for the development of individual differences in the hypothalamic-pituitary-adrenal stress response

1993 • 127 citations

Positron emission tomographic studies of sensory stimuli, cognitive processes and anxiety.

1983 • 127 citations

Induction of mood and mood shift

1980 • 126 citations

Outcome of patients with chronic affective disorder: a five-year follow- up

1990 • 124 citations

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

1991 • 124 citations

A functional cerebral response to frightening visual stimulation

1993 • 118 citations

Segregated processing of facial identity and emotion in the human brain: A pet study

1994 • 118 citations

State changes in brain activity shown by the uptake of 99mTc-exametazime with single photon emission tomography in major depression before and after treatment

1993 • 117 citations

Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys

1996 • 115 citations

Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.

1996 • 115 citations

CO2 challenge of patients with panic disorder

1987 • 114 citations

Mood-induction research—its implications for clinical depression

1982 • 114 citations

Low plasma γ-aminobutyric acid levels in male patients with depression

1992 • 110 citations

Brain activation during the generation of nonemotional and emotional plans

1995 • 109 citations

In VivoEvidence for the Involvement of Dopamine-D2Receptors in Striatum and Anterior Cingulate Gyrus in Major Depression

1997 • 108 citations

Topography of Corticostriatal Projections in Nonhuman Primates and Implications for Functional Parcellation of the Neostriatum

1986 • 107 citations

Affective and attentive neural networks in humans

1995 • 106 citations

Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects

1993 • 105 citations

Projections from the lateral nucleus to the basal nucleus of the amygdala: A light and electron microscopic PHA‐L study in the rat

1992 • 104 citations

Functional Brain Imaging, Limbic Function, and Affective Disorders

1996 • 97 citations

Major depression in Parkinson's disease and the mood response to intravenous methylphenidate: possible role of the "hedonic" dopamine synapse.

1989 • 96 citations

Animal Behavioural Studies in the Evaluation of Antidepressant Drugs

1992 • 96 citations

Brain mechanisms in human classical conditioning

1995 • 94 citations

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

1989 • 92 citations

Cultural perspectives of grief: an expanded concept analysis

1996 • 91 citations

The Reward System of the Brain

1978 • 88 citations

COGNITIVE FUNCTION AND REGIONAL CEREBRAL BLOOD FLOW IN PARKINSON'S DISEASE

1992 • 87 citations

Multiple-unit activity of the rabbit medial geniculate nucleus in conditioning, extinction, and reversal

1976 • 83 citations

Neuropsychology of Human Emotion

1984 • 80 citations

Cerebral Glucose Utilization Is Reduced in Second Test Session

1997 • 74 citations

Serotonergic dysfunction in depression associated with Parkinson's disease

1992 • 74 citations

Serotonin in the basal ganglia: functions and interactions with other neuronal pathways.

1981 • 73 citations

Implicit and Explicit Learning: Differential Effects of Affective States

1994 • 71 citations

Clinical correlates of PET- and SPECT-identified defects in dementia.

1994 • 64 citations

Frontal Lobotomy and Affective Behavior: A Neurophysiological Analysis

1951 • 64 citations

Metabolism of Dopa in Parkinsonism

1969 • 64 citations

Retuning the brain by fear conditioning.

1995 • 64 citations

Effects of self-generated sad mood on regional cerebral activity: A PET study in normal subjects

1996 • 60 citations

Right hemisphere sensitivity to arousal and depression

1992 • 60 citations

Direct amygdaloid projections to the dorsal motor nucleus of the vagus nerve: a light and electron microscopic study in the rat

1983 • 56 citations

Verbal and non-verbal recall by depressed and euthymic affective patients

1986 • 55 citations

Scientific Basis of Clinical Neurology

1986 • 55 citations

Transient brain activity used in magnetic resonance imaging to detect functional areas

1996 • 54 citations

Positron emission tomography studies of cerebral glucose metabolism in obsessive compulsive disorder.

1994 • 52 citations

Psychobiological Consequences of Social Relationships^a

1997 • 50 citations

Multiple sclerosis--presenting as depressive illness.

1977 • 45 citations

Anxiety Precipitated by Lactate

1969 • 44 citations

Forebrain neurons driven by rewarding stimulation of the medial forebrain bundle in the rat: comparison of psychophysical and electrophysiological estimates of refractory periods

1989 • 43 citations

Depression of Energy Metabolism in Distant Brain Structures: Studies with Positron Emission Tomography in Stroke Patients

1989 • 43 citations

Mesial temporal cortex hypoperfusion is associated with depression in subcortical stroke.

1994 • 42 citations

Huntington’s disease as a model for mood disorders

1990 • 36 citations

Bericht über die Gehirnpathologie in ihrer Bedeutung für Neurologie und Psychiatrie

1937 • 35 citations

Neuropsychological and biomedical assessment of depression-dementia syndromes

1989 • 34 citations

Limbic System, Basal Ganglia, and Dopaminergic Neurons

1989 • 34 citations

Differentiating dementia from "pseudodementia" early in the clinical course: Utility of neuropsychological tests.

1992 • 32 citations

The discovery of self-stimulation and other stories

1989 • 32 citations

Spontaneous remission of post-stroke depression and temporal changes in cortical S2-serotonin receptors

1991 • 29 citations

Posttraumatic Stress and Depression

1997 • 28 citations

The frontal lobes and neurosurgery for psychiatric disorders

1997 • 27 citations

β-Carboline-Induced Anxiety States

1984 • 25 citations

Positron-emission tomographic studies of the relationship of cerebral glucose metabolism and the magnitude of anxiety and hostility experienced during dreaming and waking

1991 • 24 citations

Receptors and Ligands in Psychiatry

1988 • 20 citations

Disease and State-Specific Effects of Mood Challenge on rCBF

1998 • 17 citations

Biological bases of brain function and disease

1994 • 12 citations

[Psychiatric and psychological aspects of Fahr syndrome].

1985 • 10 citations

Recognition of Mental Disorders-Reply

1982 • 2 citations

Deleted Work

1955 • 0 citations