Neuropharmacologic Modulation of Hepatic Encephalopathy: Experimental and Clinical Data

Pharmacological Reviews

2024 • 2,716 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

5-Hydroxytryptamine receptors

2001 • 693 citations

5‐Hydroxytryptamine Receptors

1993 • 524 citations

Handbook of the hypothalamus

1979 • 496 citations

The liver: Biology and pathobiology

1988 • 312 citations

HEPATIC ENCEPHALOPATHY AND THE γ-AMINOBUTYRIC-ACID NEUROTRANSMITTER SYSTEM

1982 • 297 citations

Elevated Brain Concentrations of 1,4-Benzodiazepines in Fulminant Hepatic Failure

1991 • 177 citations

IMPROVEMENT OF HEPATIC ENCEPHALOPATHY TREATED WITH FLUMAZENIL

1988 • 168 citations

Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: Characterization of an improved model and study of amino acid-ergic neurotransmission†

1989 • 166 citations

Amelioration of hepatic encephalopathy by pharmacologic antagonism of the GABAA-benzodiazepine receptor complex in a rabbit model of fulminant hepatic failure

1987 • 144 citations

Successful long-term treatment of portal-systemic encephalopathy by the benzodiazepine antagonist flumazenil

1989 • 130 citations

Flumazenil in cirrhotic patients in hepatic coma: A randomized double-blind placebo-controlled crossover trial

1994 • 128 citations

Experimental Hepatic Encephalopathy: Changes in the Binding of γ-Aminobutyric Acid

1982 • 126 citations

Supersensitivity of Benzodiazepine Receptors in Hepatic Encephalopathy Due to Fulminant Hepatic Failure in the Rat: Reversal by a Benzodiazepine Antagonist

1984 • 125 citations

Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands

1990 • 123 citations

Endogenous Benzodiazepine Receptor Ligands in Human and Animal Hepatic Encephalopathy

1990 • 119 citations

Effects of the benzodiazepine receptor antagonist flumazenil in hepatic encephalopathy in humans

1989 • 114 citations

Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas.

1984 • 107 citations

Visual Evoked Potentials in a Rabbit Model of Hepatic Encephalopathy

1984 • 93 citations

Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy.

1990 • 82 citations

Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide—induced acute liver failure

1990 • 65 citations

Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy

1994 • 62 citations

The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat

1991 • 57 citations

Brain monoamines in human hepatic encephalopathy

1978 • 53 citations

Current concepts in the pathophysiology of hepatic encephalopathy

1992 • 51 citations

On the Mode of the Prolactin Release-Inhibiting Action of the Serotonin Receptor Blockers Metergoline, Methysergide, and Cyproheptadine*

1981 • 50 citations

Flumazenil therapy for hepatic encephalopathy. A double-blind cross over study.

1995 • 46 citations

Recent advances in hepatology

1985 • 41 citations

Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: Comparison with uremic encephalopathy

1991 • 40 citations

Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit

1990 • 34 citations

A benzodiazepine antagonist does not alter the course of hepatic encephalopathy or neural ?-aminobutyric acid (GABA) binding

1987 • 33 citations

Pharmacokinetics of benzodiazepine antagonist Ro 15–1788 in cirrhotic patients with moderate or severe liver dysfunction

1989 • 29 citations

Decrease of brain zinc in experimental hepatic encephalopathy

1983 • 23 citations

Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines

1993 • 21 citations

Serotonin Agonists and Antagonists in Experimental Hypertension

1987 • 19 citations

Serotonin Agonists and Antagonists in Experimental Hypertension

1987 • 17 citations

Elevated Brain Concentrations of 1, 4-Benzodiazepines in Fulminant Hepatic Failure

1992 • 13 citations

Immediate improvement of hepatic encephalopathy (HE) in cirrhotic patients by flumazenil. Results of a double-blind cross-over study

1991 • 10 citations

The turnover of brain monoamines after total hepatectomy in rats infused with branched chain amino acids

1987 • 8 citations