Elevated Brain Concentrations of 1,4-Benzodiazepines in Fulminant Hepatic Failure

Neuropsychopharmacology

1990 • 1,545 citations

The Hepatic Coma Syndromes and Lactulose

1980 • 302 citations

HEPATIC ENCEPHALOPATHY AND THE γ-AMINOBUTYRIC-ACID NEUROTRANSMITTER SYSTEM

1982 • 297 citations

IMPROVEMENT OF HEPATIC ENCEPHALOPATHY TREATED WITH FLUMAZENIL

1988 • 168 citations

A Rapid, Comprehensive Screening Procedure for Basic Drugs in Blood or Tissues by Gas Chromatography

1978 • 153 citations

"Endogenous" benzodiazepine activity in body fluids of patients with hepatic encephalopathy

1990 • 150 citations

Amelioration of hepatic encephalopathy by pharmacologic antagonism of the GABAA-benzodiazepine receptor complex in a rabbit model of fulminant hepatic failure

1987 • 144 citations

The Liver

1989 • 143 citations

Secondary Metabolism in Microorganisms, Plants and Animals

1984 • 139 citations

Pathogenesis of hepatic encephalopathy

1987 • 136 citations

REVERSAL OF HEPATIC COMA BY BENZODIAZEPINE ANTAGONIST (Ro 15-1788)

1985 • 132 citations

Successful long-term treatment of portal-systemic encephalopathy by the benzodiazepine antagonist flumazenil

1989 • 130 citations

Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands

1990 • 123 citations

Endogenous Benzodiazepine Receptor Ligands in Human and Animal Hepatic Encephalopathy

1990 • 119 citations

Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.

1986 • 116 citations

Effects of the benzodiazepine receptor antagonist flumazenil in hepatic encephalopathy in humans

1989 • 114 citations

Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin

1987 • 86 citations

Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy.

1990 • 82 citations

Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy

1988 • 78 citations

GABA_A Receptor Complex in an Experimental Model of Hepatic Encephalopathy: Evidence for Elevated Levels of an Endogenous Benzodiazepine Receptor Ligand

1989 • 69 citations

Occurrence of pharmacologically active benzodiazepines in trace amounts in wheat and potato

1988 • 62 citations

Increased brain uptake of γ-aminobutyric acid in a rabbit model of hepatic encephalopathy

1990 • 60 citations

Presence of benzodiazepine-like molecules in mammalian brain and milk

1988 • 54 citations

The Release of Basic Drugs by the Enzymic Digestion of Tissues in Cases of Poisoning

1977 • 49 citations

Increase of natural benzodiazepines in wheat and potato during germination

1988 • 31 citations

The contribution of endogenous benzodiazepine receptor ligands to the pathogenesis of hepatic encephalopathy

1991 • 31 citations

Occurrence of ‘natural’ diazepam in human brain

1990 • 31 citations

Evidence for the presence of a benzodiazepine receptor binding substance in cerebrospinal fluid of a rabbit model of hepatic encephalopathy

1989 • 27 citations

Untitled

1985 • 22 citations