The Roles of α4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

The route of re-circulation of lymphocytes in the rat

1964 • 1,449 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

A tissue-specific endothelial cell molecule involved in lymphocyte homing

1988 • 725 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules.

1976 • 680 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.

1988 • 639 citations

Binding of L-Selectin to the Vascular Sialomucin CD34

1993 • 629 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

1996 • 405 citations

A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture.

1991 • 399 citations

MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1

1993 • 383 citations

The pathophysiologic role of alpha 4 integrins in vivo.

1994 • 380 citations

Leukocyte Migration and Adhesion

1995 • 365 citations

Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells.

1997 • 364 citations

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

1992 • 334 citations

Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7

1996 • 329 citations

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.

1991 • 306 citations

Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing.

1988 • 302 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues.

1991 • 295 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

1992 • 243 citations

Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY.

1992 • 232 citations

Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation.

1993 • 223 citations

Expression and regulation of β₇(βp) integrins on mouse lymphocytes: Relevance to the mucosal immune system

1991 • 222 citations

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium.

1993 • 218 citations

Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse.

1994 • 216 citations

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile.

1994 • 211 citations

Lymphocyte Targeting of the Central Nervous System: A Review of Afferent and Efferent CNS‐Immune Pathways

1996 • 210 citations

Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice

1996 • 208 citations

Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen.

1995 • 188 citations

Global vascular expression of murine CD34, a sialomucin-like endothelial ligand for L-selectin

1994 • 185 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1.

1993 • 171 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing.

1992 • 145 citations

To The Pathogenesis of Diabetes Mellitus

1954 • 136 citations

Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis

1994 • 131 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice.

1994 • 121 citations

Involvement of β7 Integrin and Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) in the Development of Diabetes in Nonobese Diabetic Mice

1997 • 115 citations

Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse.

1991 • 112 citations

The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.

1994 • 104 citations

Mucosa-Associated (βT-integrinhigh) Lymphocytes Accumulate Early in the Pancreas of NOD Mice and Show Aberrant Recirculation Behavior

1996 • 95 citations

A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice.

1994 • 95 citations

Antigen‐presenting cells in adoptively transferred and spontaneous autoimmune diabetes

1993 • 91 citations

Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis

1994 • 83 citations

The α4β1/VCAM-1 adhesion pathway in physiology and disease

1993 • 80 citations

Specialization of mucosal follicular dendritic cells revealed by mucosal addressin-cell adhesion molecule-1 display.

1997 • 79 citations

Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway.

1996 • 72 citations

Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb

1994 • 71 citations

Expression of Intercellular Adhesion Molecule 1 on Pancreatic β-Cells Accelerates β-Cell Destruction by Cytotoxic T-Cells in Murine Autoimmune Diabetes

1995 • 63 citations

Lack of L‐selectin expression by cells transferring diabetes in NOD mice: insights into the mechanisms involved in diabetes prevention by Mel‐14 antibody treatment

1995 • 52 citations

Protection Against Adoptive Transfer of Autoimmune Diabetes Mediated Through Very Late Antigen-4 Integrin

1994 • 49 citations

Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF-receptor p55.

1996 • 46 citations

L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus.

1995 • 44 citations

The monoclonal antibody MEL‐14 can block lymphocyte migration into a site ofchronic inflammation

1992 • 38 citations

Developmental regulation of vascular addressin expression: a possible role for site-associated environments

1993 • 37 citations

Induction of vascular addressins and adhesion molecules in the pancreas of IFN-gamma transgenic mice.

1994 • 36 citations

Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice.

1995 • 35 citations

Administration of Monoclonal Antibodies against Vascular Cell Adhesion Molecule-1/Very Late Antigen-4 Abrogates Predisposing Autoimmune Diabetes in NOD Mice

1995 • 34 citations

Lymphocyte Function Associated Antigen-1, Integrin α4, and L-Selectin Mediate T-Cell Homing to the Pancreas in the Model of Adoptive Transfer of Diabetes in NOD Mice

1996 • 34 citations

Expression of intercellular adhesion molecule 1 on pancreatic beta-cells accelerates beta-cell destruction by cytotoxic T-cells in murine autoimmune diabetes

1995 • 24 citations

Homing of lymphocytes into islets of Langerhans in prediabetic non-obese diabetic mice is not restricted to autoreactive T cells

1995 • 23 citations

Mucosa-associated (beta 7-integrinhigh) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior

1996 • 17 citations

Traffic of peripheral B and T lymphocytes to hyperplastic, preneoplastic thymuses of AKR mice.

1991 • 13 citations

Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin

1994 • 11 citations

Differences in Adhesion Markers, Activation Markers, and TcR in Islet Infiltratingvs.Peripheral Lymphocytes in the NOD Mouse

1995 • 10 citations

Lymphocyte function associated antigen-1, integrin alpha 4, and L-selectin mediate T-cell homing to the pancreas in the model of adoptive transfer of diabetes in NOD mice

1996 • 9 citations

Deleted Work

1955 • 0 citations