Concomitant Tumor Immunity and the Resistance to a Second Tumor Challenge

The Concept of Immunological Surveillance

2015 • 1,586 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Natural Cell-Mediated Immunity

1978 • 1,063 citations

Role of Polyamines in the Control of Cell Proliferation and Differentiation

1981 • 935 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Dynamics of Tumor Growth

1964 • 815 citations

Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.

1960 • 736 citations

Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.

1953 • 686 citations

Natural Cell-mediated Immunity Against Tumors

1980 • 666 citations

Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens

1974 • 651 citations

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

1979 • 638 citations

NK Cells and Other Natural Effector Cells

1982 • 624 citations

ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 • 528 citations

Immunology of Experimental Tumors

1964 • 487 citations

Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

1974 • 484 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Methods for the study of histocompatibility genes

1948 • 469 citations

Platelet—tumor‐cell interactions in mice. The role of platelets in the spread of malignant disease

1973 • 447 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE

1969 • 417 citations

Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture.

1981 • 395 citations

Role of Natural Killer Cells in the Destruction of Circulating Tumor Emboli23

1980 • 389 citations

Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

1980 • 383 citations

T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.

1980 • 373 citations

Role of NK cells in the control of metastatic spread and growth of tumor cells in mice

1982 • 357 citations

An Analysis of the Murine NK Cell as to Structure, Function and Biological Relevance

1979 • 351 citations

Tumor Antigens

1966 • 323 citations

Immunodepression and Malignancy

1976 • 310 citations

Immunologic Mechanisms in UV Radiation Carcinogenesis

1981 • 295 citations

MECHANISMS OF ACQUIRED RESISTANCE IN MOUSE TYPHOID

1966 • 288 citations

Platelets: A Multidisciplinary Approach

1979 • 275 citations

Prostaglandins and cancer: A review of tumor initiation through tumor metastasis

1981 • 273 citations

Cell-Mediated Immunity to Tumor Cells

1974 • 268 citations

Nutrition in Relation to Cancer.

1948 • 256 citations

Passive Immunotherapy of Cancer in Animals and Man

1977 • 245 citations

THE INFLUENCE OF DIET ON TRANSPLANTED AND SPONTANEOUS MOUSE TUMORS

1914 • 241 citations

IMMUNOLOGICAL FACTORS IN THE PROCESS OF CARCINOGENESIS

1964 • 232 citations

HOST-PARASITE RELATIONS IN MOUSE TYPHOID

1966 • 230 citations

Some Recent Work on Tumor Immunity

1956 • 225 citations

Genetically determined immunodeficiency diseases (GDID) and malignancy: Report from the Immunodeficiency-Cancer Registry

1978 • 223 citations

Transplantation methods as a tool for detection of tumor-specific antigens.

1965 • 222 citations

IMMUNITY IN SCHISTOSOMIASIS

1969 • 214 citations

Malignancies associated with immunosuppressive or cytotoxic therapy.

1978 • 212 citations

Mutation and Human Cancer

1973 • 210 citations

Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?

1978 • 205 citations

Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages.

1974 • 205 citations

A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies.

1979 • 199 citations

Transplantation Methods as a Tool for Detection of Tumor-specific Antigens*

2015 • 183 citations

In vivo natural reactivity of mice against tumor cells

1980 • 174 citations

Immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: contrasting consequences of host versus tumor evolution.

1977 • 169 citations

Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor-related systemic growth-retarding factors.

1972 • 167 citations

Immunosuppression and the Role of Suppressive Factors in Cancer

1977 • 162 citations

Suppressor Cells: Permitters and Promoters of Malignancy?

1979 • 162 citations

Immunological resistance to pulmonary metastases in C3Hf-Bu mice bearing syngeneic fibrosarcoma of different sizes.

1974 • 149 citations

Evidence for an Immunological Reaction of the Host Directed Against Its Own Actively Growing Primary Tumor<xref ref-type="fn" rid="FN1">2</xref>

1966 • 148 citations

Host-tumor interaction and nutrient supply

1980 • 145 citations

Quantitative studies of autotransplantation of human cancer.Preliminary report

1961 • 145 citations

Immunology '80—Progress in Immunology IV

1982 • 145 citations

Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene.

1970 • 144 citations

Relationship Between Metastatic Potential and Resistance to Natural Killer Cellmediated Cytotoxicity in Three Murine Tumor Systems2, 3

1981 • 142 citations

Cancer invasion and metastasis : biologic mechanisms and therapy

1977 • 135 citations

Glucose consumption by transplanted tumors in vivo.

1967 • 133 citations

Analysis of Antigenic Heterogeneity Within Individual 3-Methylcholanthrene-Induced Mouse Sarcomas<xref ref-type="fn" rid="FN2">2</xref>

1970 • 126 citations

CANCER CACHEXIA AND GLUCONEOGENESIS

1974 • 124 citations

Death and Metastatic Distribution of Tumor Cells in Mice Monitored With <sup>125</sup>I-Iododeoxyuridine<xref ref-type="fn" rid="FN2">2</xref>

1969 • 122 citations

On Concomitant Immunity in Tumour-bearing Hamsters

1967 • 120 citations

Do Macrophages Destroy Nascent Tumors?<xref ref-type="fn" rid="FN5">5</xref>

1979 • 119 citations

Some aspects of nitrogen and energy metabolism in cancerous subjects: a review.

1951 • 115 citations

Cyclic AMP and the Transformation of Fibroblasts

1974 • 115 citations

An experimental study of postoperative tumor metastases.I. Growth of pulmonary metastases following total removal of primary leg tumor

1958 • 109 citations

Differences in Cell Surface Antigens of Tumor Metastases and Those of the Local Tumor2

1979 • 108 citations

Antigenic Specificity of Benzo[a]pyrene-Induced Sarcomas2

1964 • 107 citations

Tumour‐specific immunity against spontneous rat tumours

1966 • 104 citations

Evolution of Cell-Mediated Immunity in Mice Bearing an Antigenic Tumor. Influence of Tumor Growth and Surgical Removal

1969 • 101 citations

T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites.

1977 • 101 citations

Tumor Progression and Homeostasis

1976 • 98 citations

Human monoclonal antibodies to lung-cancer antigens

1981 • 98 citations

Tumor cell antigenicity, host immunity, and cancer metastasis

1980 • 96 citations

GROWTH OF A LOCAL TUMOR EXERTS A SPECIFIC INHIBITORY EFFECT ON PROGRESSION OF LUNG METASTASES

1978 • 96 citations

The Physiopathology of Cancer

1954 • 95 citations

The effect of tumor size on concomitant tumor immunity.

1973 • 93 citations

Immunologic Heterogeneity of Tumor Cell Subpopulations From a Single Mouse Mammary Tumor<xref ref-type="fn" rid="FN2">2</xref>

1979 • 93 citations

The cellular immune response to primary sarcomata in rats II. Abnormal responses of nodes draining the tumour

1969 • 92 citations

Cancer Invasion and Metastasis

1980 • 92 citations

Decreased “natural killer” effect in tumor‐bearing mice and its relation to the immunity against oncorna virus‐determined cell surface antigens

1976 • 89 citations

Altered antigenicity in spontaneous pulmonary metastases from an antigenic murine sarcoma.

1972 • 89 citations

HOW TUMORS AFFECT HOST METABOLISM*

1974 • 89 citations

Demonstration of host resistance against isotransplantation of lymphomas induced by the Gross agent.

1962 • 88 citations

Tumor-Bound Immunoglobulins:in SituExpressions Of Humoral Immunity

1977 • 88 citations

Humoral and cellular factors in homograft and isograft immunity against sarcoma cells.

1960 • 87 citations

Evolution of cell‐mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells

1972 • 86 citations

Malignancy and the Hemostatic System

1982 • 85 citations

Studies of the significance of tumor antigens in induction and repression of neoplastic diseases: presidential address.

1969 • 84 citations

The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity.

1978 • 83 citations

The role of antibodies in immunity to transplanted leukæmia in mice

1942 • 82 citations

Growth of carcinoma implants in fed and fasted rats.

1952 • 82 citations

The development of spontaneous metastases after the removal of a “primary” tumorII. Standardization protocol of 5 animal tumors

1961 • 78 citations

On the Multiform Relationships between the Tumor

1979 • 76 citations

Transplantation Immunity to Simian Virus 40-Transformed Cells in Tumor-Bearing Mice. I. Development of Cellular Immunity to Simian Virus 40 Tumor-Specific Transplantation Antigens During Tumorigenesis by Transplanted Cells2

1973 • 75 citations

Concomitant immunity and specific depression of immunity by residual or reinjected syngeneic tumor tissue.

1971 • 73 citations

Antigenic differences between primary methylcholanthrene‐induced rat sarcomas and post‐surgical recurrences

1977 • 72 citations

The Role of DNA Repair and Somatic Mutation in Carcinogenesis

1975 • 72 citations

Behavior of opposing pathways of thymidine utilization in differentiating, regenerating, and neoplastic liver.

1971 • 70 citations

Host Resistance to Cancer

1965 • 70 citations

Immunosurveillance, Regeneration and Oncogenesis1

2015 • 69 citations

Natural Polyclonality of Spontaneous AKR Leukemia and Its Consequences for So-Called Specific Immunotherapy2

1979 • 69 citations

In vitro NK‐activity and in vivo resistance to leukemia: Studies of beige, beige/nude and wild‐type hosts on C57BL background

1980 • 69 citations

Changes in polyamine metabolism in WI38 cells stimulated to proliferate

1975 • 65 citations

Control of Lung Metastasis Progression in Mice: Role of Growth Kinetics of 3LL Lewis Lung Carcinoma and Host Immune Reactivity<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1980 • 62 citations

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

1975 • 62 citations

Macrophage behaviour during the complaisant phase of murine pertussis.

1969 • 62 citations

Immunologic Defenses against Metastases: Impairment by Excision of an Allotransplanted Lymphoma

1968 • 61 citations

Immune Status of the Primary Host Toward Its Own Methylcholanthrene-Induced Sarcomas<xref ref-type="fn" rid="FN2">2</xref>

1968 • 61 citations

Tumor-specific Immunity to Transplanted Dibenz[a,h]-anthracene-induced Sarcomas

1960 • 58 citations

Demonstration of Tumor-Specific Immunity Against Antigens Unrelated to the Mammary Tumor Virus in Spontaneous Mammary Adenocarcinomas<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 58 citations

Antigenic diversity of tumors chemically induced within the progeny of a single cell

1972 • 55 citations

The role of the regional lymph nodes in the immunity to a chemically induced sarcoma in C3H mice.

1969 • 53 citations

The inhibitory influence of a transplanted hamster lymphoma on metastasis.

1960 • 53 citations

Genetics of Cancer

1948 • 52 citations

Atrophy of tumors caused by strangulation and accompanied by development of tumor immunity in rats

1952 • 51 citations

In vivo monitoring of the death rate of artificial murine pulmonary micrometastases.

1978 • 51 citations

On the mechanism of tumor ‘concomitant immunity’

1981 • 50 citations

Immune surveillance revisited

1977 • 50 citations

The Newer Concept of Cancer Toxin

1958 • 49 citations

Specific growth regulation in three ascitic tumours

1972 • 47 citations

CONCOMITANT IMMUNITY TO SYNGENEIC METHYLCHOLANTHRENE INDUCED TUMOURS IN MICE. OCCURRENCE AND SPECIFICITY OF CONCOMITANT IMMUNITY

1973 • 47 citations

Intravenous nutrition and tumor host protein metabolism

1977 • 45 citations

Radioisotope assay for evaluation of in vivo natural cell‐mediated resistance of mice to local transplantation of tumor cells

1981 • 42 citations

Immunologically nonspecific enhancement of artificial lung metastases in tumor-bearing mice

1979 • 41 citations

IMMUNITY TO SPONTANEOUS AND METHYLCHOLANTHRENE-INDUCED TUMORS IN INBRED MICE.

1964 • 38 citations

Tumor Cell Cytotoxicity by Granulocytes From Peripheral Blood of Tumor-Bearing Mice 2

1978 • 38 citations

Tumor Development in Susceptible Strain A and Resistant Strain L Lung Transplants in LA F<sub>1</sub> Hosts

1951 • 37 citations

Resistance of tumor-bearing mice to a second tumor challenge.

1983 • 34 citations

The development and specific suppression of concomitant immunity in two syngeneic tumour‐host systems

1973 • 33 citations

On the structure and bioligical effects of a newly-discovered cytotoxic polypeptide in tumor fluid

1965 • 32 citations

Genetic studies on the transplantation of two adenocarcinomata

1924 • 32 citations

Alterations of mononuclear phagocyte function induced by Lewis lung carcinoma in C57BL mice

1977 • 30 citations

Tumor‐associated antigenic differences between the primary and the descendant metastatic tumor cell populations

1979 • 29 citations

The influence of calories per se upon the growth of sarcoma 180.

1938 • 27 citations

The adoptive transfer of concomitant immunity to murine tumor isografts with spleen cells from tumor-bearing animals.

1971 • 27 citations

SPECIFIC TRANSPLANTATION IMMUNITY IN RELATION TO ROUS SARCOMA VIRUS TUMORIGENESIS IN MICE

1966 • 27 citations

Control of progression of local tumor and pulmonary metastasis of the 3LL Lewis lung carcinoma by different histocompatibility requirements in mice.

1981 • 26 citations

Comparison of Concomitant and Sinecomitant Tumor Immunity

1970 • 26 citations

Muscle protein biosynthesis in the tumour-bearing rat

1975 • 26 citations

Macrophages and lymphoid tissues in mice with concomitant tumour immunity

1976 • 25 citations

Modulation of Lung Tumor Colony Formation by a Subcutaneously Growing Tumor

1981 • 24 citations

Calorie Restriction: Effect on Growth of Human Tumors Heterotransplanted in Nude Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1982 • 23 citations

A growth-modifying factor from cell lines of human malignant origin.

1970 • 22 citations

Total intravenous hyperalimentation and hydroxyurea chemotherapy in hepatoma-bearing rats

1977 • 22 citations

In vivo anti-tumor effects of local adoptive transfer of mouse and human cultured lymphoid cells

1981 • 21 citations

Concomitant immunity in hamsters bearing dmba‐induced tumor transplants

1969 • 21 citations

Surveillance against neoplastic cells-is it mediated by macrophages?

1976 • 20 citations

Experimentelle Untersuchungen über Metastasen bei Mäusecarcinom

1924 • 19 citations

Serotherapy of Malignant Disease1

2015 • 19 citations

GENETIC AND ENDOCRINE STUDIES ON A TRANSPLANTABLE CARCINOMA OF THE OVARY

1938 • 19 citations

Proliferative Capacity of Leukemic Cells in AKR Leukemia&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1970 • 17 citations

Acquired immunodeficiency syndrome cause(s) still elusive

1982 • 15 citations

The fate of circulating methylcholanthrene tumor cells in mice with tumor-specific immunity

1971 • 13 citations

Dietary deficiency of protein, amino acids and total calories on development and growth of cancer

1979 • 12 citations

BCG, Levamisole and Transfer Factor in the Treatment of Cancer

2015 • 11 citations

Prostaglandins and Neoplasia

1981 • 10 citations

The role of adenosine triphosphate, chalones, and specific proteins in controlling tumor growth fraction.

1975 • 10 citations

Immunotherapy of Cancer: Current Status1

2015 • 10 citations

EFFECTS OF LOCAL REACTION IN SPONTANEOUS TUMORS OF ANIMALS AND HUMAN BEINGS

1940 • 9 citations

The Genetic Aspects of Human Cancer

1976 • 9 citations

DNA‐SYNTHESIS TIME OF BONE MARROW CELLS IN HEALTHY AND ASCITES TUMOR‐BEARING MICE

1972 • 9 citations

Some immunogenic and biochemical properties of tumor-associated transplantation antigens (TATA) obtained in soluble form or solubilized from two methylcholanthrene-induced sarcomas, meth A and CI-4

1981 • 8 citations

The effect of necrosis and tumor on the cell kinetics of small bowel.

1966 • 7 citations

Variations in the Level of Haematogenous Antitumour Immunity during Progressive Tumour Growth and Spontaneous Blood-Borne Metastatic Spread

1979 • 4 citations

A mouse model for immunotherapy of osteosarcoma

1980 • 4 citations

Cytokinetics of the Krebs 2 carcinoma. I. Its effect on the cell population kinetics of duodenal crypt proliferation

1968 • 2 citations

Alcohol and cancer workshop. National Institutes of Health, Bethesda, Maryland, 23-24 October 1978.

1979 • 2 citations