Role of Polyamines in the Control of Cell Proliferation and Differentiation

Polyamines in rapid growth and cancer

1978 • 1,354 citations

1,4-Diaminobutane (Putrescine), Spermidine, and Spermine

1976 • 1,203 citations

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

Introduction to the polyamines

1971 • 682 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

Function of naturally occurring polyamines

1973 • 532 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

Anti-proliferative properties of DL-α-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

1978 • 398 citations

Advances in polyamine research

1978 • 369 citations

Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases

1972 • 344 citations

Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase

1977 • 336 citations

Polyamines in Biomedical Research

1981 • 311 citations

Regulation of Amino Acid Decarboxylation

1974 • 297 citations

Polyamines in Mammalian Biology and Medicine

1979 • 295 citations

The regulation and function of ornithine decarboxylase and of the polyamines.

1979 • 247 citations

L-Ornithine Decarboxylase: an Essential Role in Early Mammalian Embryogenesis

1980 • 239 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.

1976 • 213 citations

Multiplication and Division in Mammalian Cells

1977 • 212 citations

Putrescine catabolism in mammalian brain

1974 • 199 citations

Physiology of the natural polyamines putrescine, spermidine and spermine.

1975 • 188 citations

Biosynthesis and Metabolism of 1,4‐diaminobutane, Spermidine, Spermine, and Related Amines

1972 • 173 citations

Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A.

1975 • 168 citations

Mutants of Escherichia coli that do not contain 1,4-diaminobutane (putrescine) or spermidine.

1979 • 158 citations

Hormones, Receptors and Breast Cancer

1979 • 150 citations

New Aspects of Polyamine Biosynthesis in Eukaryotic Organisms

1972 • 129 citations

Specific inhibition of the enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances

1974 • 126 citations

Polyamine accumulation during lymphocyte transformation and its relation to the synthesis, processing, and accumulation of ribonucleic acid

1973 • 119 citations

Effect of methylglyoxal bis(guanylhydrazone) on polyamine metabolism in normal and regenerating rat liver and rat thymus

1973 • 119 citations

Spermidine as a Possible Mediator of Glucocorticoid Effect on Milk Protein Synthesis in Mouse Mammary Epithelium in Vitro

1974 • 119 citations

Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis ; Effects of α-difluoromethyl- ornithine, an irreversible inhibitor or ornithine decarboxylase

1980 • 117 citations

Studies of inhibition of rat spermidine synthase and spermine synthase

1980 • 114 citations

Induction of ornithine decarboxylase by nerve growth factor dissociated from effects on survival and neurite outgrowth

1978 • 109 citations

Ornithine decarboxylase activity in relation to growth of rat liver. Effects of partial hepatectomy, hypertonic infusions, celite injection or other stressful procedures.

1970 • 104 citations

Biphasic induction of ornithine decarboxylase and putrescine levels in growing HTC cells

1975 • 104 citations

Changes in L-ornithine decarboxylase activity during the cell cycle

1976 • 99 citations

Arginaseless Neurospora : Genetics, Physiology, and Polyamine Synthesis

1970 • 94 citations

Isolation and characterization of Saccharomyces cerevisiae mutants deficient in S-adenosylmethionine decarboxylase, spermidine, and spermine

1978 • 93 citations

Isolation, characterization, and mapping of Escherichia coli mutants blocked in the synthesis of ornithine decarboxylase

1975 • 89 citations

Suppression of the formation of polyamines and macromolecules by <scp>dl</scp>-α-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes

1979 • 88 citations

Polyamine auxotrophs of Saccharomyces cerevisiae

1978 • 87 citations

Nerve growth factor‐mediated selective induction of ornithine decarboxylase in rat pheochromocytoma; a cyclic amp‐independent process

1978 • 85 citations

Polyamine Synthesis in Mammalian Tissues. Isolation and Characterization of Spermine Synthase from Bovine Brain

1979 • 85 citations

Polyamine‐Induced Actin Polymerization

1978 • 84 citations

Analogs of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site

1978 • 83 citations

Effect of DL-α-Hydrazino-δ-aminovaleric Acid, an Inhibitor of Ornithine Decarboxylase, on Polyamine Metabolism in Isoproterenol-stimulated Mouse Parotid Glands1

1975 • 82 citations

Polyamine biosynthesis enzymes in the induction and inhibition of differentiation in Friend erythroleukemia cells.

1980 • 81 citations

Inhibition of murine embryonic development by α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase

1980 • 80 citations

Ornithine decarboxylase activity in relation to growth of rat liver

1970 • 79 citations

Isolation and Characterization of a Mutant of Escherichia coli Blocked in the Synthesis of Putrescine

1970 • 77 citations

Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liver

1976 • 76 citations

Synthesis and accumulation of polyamines in rat liver regenerating after treatment with carbon tetrachloride

1973 • 75 citations

Studies on the regulation of ornithine decar☐ylase activity by the microtubules: The effect of colchicine and vinblastine

1976 • 75 citations

Effect of inhibition of spermidine formation on protein and nucleic acid synthesis during lymphocyte activation

1973 • 75 citations

Diamine and polyamine oxidase activities in normal and transformed cells

1979 • 74 citations

Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.

1979 • 73 citations

PUTRESCINE AS A GROWTH FACTOR FOR HEMOPHILUS PARAINFLUENZAE

1948 • 73 citations

Effect of growth conditions on the ornithine decarboxylase activity of rat hepatoma cells

1971 • 72 citations

Inhibitors of polyamine biosynthesis. 1. .alpha.-Methyl-(+-)-ornithine, an inhibitor of ornithine decarboxylase

1974 • 71 citations

Putrescine as an Essential Growth Factor for a Mutant of Aspergillus nidulans

1955 • 71 citations

Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.

1977 • 70 citations

Arginase affects lactogenesis through its influence on the biosynthesis of spermidine

1974 • 70 citations

Nerve growth factor increases activity of ornithine decarboxylase in rat brain

1978 • 69 citations

Initial characterization of a HTC cell variant partially resistant to the anti-proliferative effect of ornithine decarboxylase inhibitors

1978 • 67 citations

Interference with S and G2 phase progression by polyamine synthesis inhibitors

1978 • 65 citations

Inhibition of spermidine and spermine synthesis leads to growth arrest of rat embryo fibroblasts in G₁

1978 • 65 citations

Changes in polyamine metabolism in WI38 cells stimulated to proliferate

1975 • 65 citations

Role of polyamines in cytokinesis of mammalian cells

1979 • 63 citations

Isolation of Conditionally Putrescine-Deficient Mutants ofEscherichia coli

1970 • 61 citations

Defect in the Split Proteins of 30‐S Ribosomal Subunits and Under‐Methylation of 16‐S Ribosomal RNA in a Polymamine‐Requiring Mutant of Escherichia coli Grown in the Absence of Polymines

1979 • 61 citations

Mammalian cell fusion. IV. Regulation of chromosome formation from interphase nuclei by various chemical compounds

1971 • 61 citations

A possible involvement of polyamines in the initiation of DNA synthesis by human WI‐38 and mouse BALB/3T3 cells

1976 • 60 citations

S-Adenosyl-L-methionine decarboxylase during lymphocyte transformation: Decreased degradation in the presence of a specific inhibitor

1973 • 57 citations

Polyamines and their role in protein synthesis

1977 • 57 citations

Escherichia coli mutants completely deficient in adenosylmethionine decarboxylase and in spermidine biosynthesis.

1978 • 55 citations

On the turnover of polyamines spermidine and spermine in mouse brain and other organs

1980 • 55 citations

Inhibitors of polyamine biosynthesis. 8. Irreversible inhibition of mammalian S-adenosyl-L-methionine decarboxylase by substrate analogs

1980 • 55 citations

DNA Synthesis in HeLa Cells and Isolated Nuclei after Treatment with an Inhibitor of Spermidine Synthesis, Methyl Glyoxal Bis(guanylhydrazone)

1977 • 54 citations

Inhibition of the synthesis of polyamines and DNA in activated lymphocytes by a combination of alpha-methylornithine and methylglyoxal bis(guanylhydrazone).

1977 • 54 citations

Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts

1979 • 51 citations

Growth and Macromolecular Composition of a Mutant of Escherichia coli During Polyamine Limitation

1973 • 50 citations

Potent inhibition of ornithine decarboxylase by β, γ unsaturated substrate analogs

1975 • 50 citations

Regulation of ornithine decarboxylase in cultured mouse mammary gland by the osmolarity in the cellular environment

1980 • 49 citations

Differential effects of inhibition of polyamine biosynthesis on cell cycle traverse and structure of the prematurely condensed chromosomes of normal and transformed cells

1979 • 48 citations

Putrescine biosynthesis in mammalial cells: Essential for DNA synthesis but not for mitosis

1977 • 47 citations

Mechanism of inactivation of ornithine decarboxylase by α-methylornithine

1978 • 47 citations

Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

1976 • 47 citations

Inhibitory effect of α-hydrazinoornithine on egg cleavage in sea urchin eggs

1978 • 46 citations

Regulation of Macromolecular Synthesis by Putrescine in a Conditional Escherichia coli Putrescine Auxotroph

1972 • 45 citations

The Cell Cycle in Malignancy and Immunity

1975 • 45 citations

α-Hydrazino-ornithine blocks net synthesis of putrescine but not of RNA and DNA

1974 • 44 citations

Polyamines and their biosynthetic enzymes in Ehrlich ascites-carcinoma cells. Modification of tumour polyamine pattern by diamines

1977 • 44 citations

Ornithine decarboxylase: Inhibition by a-hydrazinoornithine

1973 • 41 citations

Polyamines and their Biosynthesis in Ehrlich Ascites Cells.

1967 • 41 citations

Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse

1977 • 40 citations

Biphasic stimulation of polyamine biosynthesis in primary mouse kidney cells by infection with polyoma virus:uncoupling from DNA and rRNA synthesis.

1976 • 40 citations

Regulation of ornithine decarboxylase by diamines in regenerating rat liver

1977 • 39 citations

Inhibition of DNA synthesis by methylglyoxal bis(guanylhydrazone) during lymphocyte transformation

1974 • 39 citations

Stimulation of deoxyribonucleic acid replication fork movement by spermidine analogs in polyamine-deficient Escherichia coli

1980 • 38 citations

STUDIES WITH MUTANTS BLOCKED IN THE SYNTHESIS OF POLYAMINES*

1970 • 38 citations

On the development of specific inhibitors of animal polyamine biosynthetic enzymes.

1976 • 38 citations

Regulation of Casein Synthesis by Polyamines in Mammary Gland Explants of Mice1

1977 • 38 citations

Dissociation of the early antiproliferative action of methylglyoxal bis(guanylhydrazone) from polyamine depletion

1979 • 37 citations

Inhibition of putrescine synthesis blocks development of the polychete Ophryotrocha labronica at gastrulation.

1978 • 37 citations

Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture

1980 • 37 citations

Differential inhibition of mammalian aminopropyltransferase activities

1978 • 37 citations

Specific increase in polyamine levels in chick embryo cells transformed by Rous sarcoma virus.

1975 • 37 citations

Studies on Methylglyoxal Bis(guanylhydrazone)¹ Analogs. II. Structural Variations on Methylglyoxal Bis(guanylhydrazone)²

1963 • 35 citations

Changes in membrane function and chromatin template activity in diploid and transformed cells in culture.

1973 • 34 citations

Polyamines, ribonucleases, and the stability of RNA

1977 • 34 citations

Regulation of ribonucleic acid synthesis by polyamines. Reversal by spermine of inhibition by methylglyoxal bis(guanylhydrazone) of ribonucleic acid synthesis and histone acetylation in rabbit heart

1975 • 34 citations

Inhibition of mammalian S-adenosylmethionine decarboxylase activity by 1,1'-((methylethanediylidene)-dinitrilo)bis(3-aminoguanidine).

1978 • 33 citations

Inhibition of polyamine accumulation and cell proliferation by derivatives of diaminopropane in Ehrlich ascites cells grown in culture

1979 • 33 citations

Polyamines in normal and in virus-transformed chick embryo fibroblasts.

1974 • 33 citations

Inhibition of prereplicative polyamine accumulation in regenerating rat liver

1977 • 32 citations

Inhibition of ornithine decarboxylase of HeLa cells by diamines and polyamines. Effect on cell proliferation

1980 • 31 citations

Cellular polyamine depletion reduces DNA synthesis in isolated lymphocyte nuclei

1978 • 30 citations

Effects of inhibitors of decarboxylase and ornithine decarboxylase on DNA synthesis in rat liver after partial hepatectomy

1978 • 30 citations

Activation of casein synthesis by prostaglandins plus spermidine in mammary gland explants of mice

1976 • 29 citations

The effects of 1,4-diaminobutanone on polyamine synthesis in Aspergillus nidulans

1977 • 29 citations

Irreversible inhibition of mammalian and yeast S-adenosylmethionine decarboxylase by 1,1′-(methylethanediylidenedinitrilo)-bis(3-aminoguanidine)

1976 • 29 citations

Ornithine decarboxylase activity and polyamines in relation to aging of human fibroblasts

1977 • 28 citations

Ornithine decarboxylase and polyamines in liver and kidneys of rats on cyclical regimen of protein-free and protein-containing diets. Relationship to deoxyribonucleic acid synthesis in liver

1977 • 28 citations

Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-<scp>l</scp>-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone)

1973 • 28 citations

Essential role of the polyamines in early chick embryo development

1980 • 28 citations

Induction of ornithine decarboxylase activity in a temperature-sensitive cell cycle mutant of Chinese hamster cells.

1978 • 27 citations

Structural specificity of the spermidine requirement of an Escherichia coli auxotroph

1980 • 27 citations

Action of decarboxylated S-adenosylmethionine analogs in the spermidine-synthesizing system from rat prostate

1980 • 27 citations

Role of spermidine in casein gene expression in the rabbit

1978 • 26 citations

Polyamine biosynthesis during germination of yeast ascospores

1979 • 25 citations

The role of putrescine in cell proliferation of the skin of mice induced by ethylphenylpropiolate

1977 • 25 citations

Reversible inhibition of rat liver regeneration by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase

1978 • 25 citations

Polyamine biosynthesis and DNA synthesis in cultured mammary gland explants from virgin mice

1978 • 25 citations

Polyamine deficiency reduces the rate of DNA replication fork movement in Escherichia coli

1978 • 24 citations

A selective effect of methylglyoxal-bis(guanylhydrazone) on the synthesis of mitochondrial DNA of cultured L1210 leukemia cells.

1979 • 24 citations

Effects of polyamines and methylglyoxal bis(guanylhydrazone) on hepatic nuclear structure and deoxyribonucleic acid template activity

1975 • 23 citations

Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.

1980 • 23 citations

The utilization of an inhibitor of spermidine and spermine synthesis as a tool for the study of the determination of cavitation in the preimplantation mouse embryo

1979 • 23 citations

Inhibitors of polyamine biosynthesis. 3. (+-)-5-Amino-2-hydrazino-2-methylpentanoic acid, an inhibitor of ornithine decarboxylase

1975 • 22 citations

Ornithine decarboxylase activity and the growth of neuroblastoma cells

1978 • 22 citations

Relationships between spermidine, glucocorticoid and milk proteins in different mammalian species

1979 • 22 citations

Synthesis of 2-methylproline and 2-methylornithine

1974 • 21 citations

Polyamine Requirements of a Conditional Polyamine Auxotroph of Escherichia coli

1973 • 21 citations

Studies on the structure—activity relationship among aliphatic and aromatic bisguanylhydrazones and some related compounds

1977 • 21 citations

The permissive effect of cortical steroids on the induction of brain ornithine decarboxylase by nerve growth factor

1978 • 20 citations

Putrescine shortens the S-period in human fibroblasts.

1975 • 20 citations

Polyamine Metabolism and DNA Synthesis in Regenerating Rat Liver12

1978 • 19 citations

Interconversion of Aliphatic Polyamines in Isoproterenol-Stimulated Mouse Parotid Glands12

1978 • 19 citations

Evolution of ornithine decarboxylase activity during the cell cycle of Euglena gracilis Z in synchronous culture Influence of vitamin B-12

1978 • 18 citations

Syntheses of ornithine decarboxylase inhibitors: D- and DL-.ALPHA.-hydrazinoornithine.

1976 • 17 citations

Possible involvement of putrescine in nucleolar formation in early embryos

1978 • 16 citations

Effect of Diaminobutene and Diaminopropane on Diet-Stimulated Polyamine Synthesis and Cell Proliferation in Rat Liver

1979 • 15 citations

Lack of a correlation between polyamine synthesis and DNA synthesis by cultured rat liver cells and fibroblasts

1978 • 15 citations

The dual action of the non-physiological diamines 1,3 diaminopropane and cadaverine on ornithine decarboxylase of HTC cells

1980 • 15 citations

Mechanism of stimulation of chromatin transcription by putrescine: effects on rate of elongation and number of initiation sites utilized

1978 • 15 citations

CHANGES IN ORNITHINE DECARBOXYLASE ACTIVITY AND CYCLIC ADENOSINE-3′-5′-MONOPHOSPHATE CONCENTRATIONS DURING THE CELL CYCLE OF SYNCHRONIZED BHK CELLS

1977 • 14 citations

Effect of 5′‐methylthioadenosine on gene action during heat shock in Drosophila melanogaster

1979 • 13 citations

The effect of methylglyoxal bis(guanylhydrazone) on vaccinia virus replication

1976 • 12 citations

Inhibition of cytomegalovirus-stimulated human cell ornithine decarboxylase by α-difluoromethylornithine

1979 • 12 citations

Suppression of phytohemagglutinin-induction of thymidine uptake in guinea pig lymphocytes by methylglyoxal bis(guanylhydrazone) treatment

1977 • 11 citations

Polyamine replacement by magnesium ions in BHK-21/C13 cells

1979 • 11 citations

Polyamines and the stimulation of DNA synthesis in chicken embryo fibroblasts by purified multiplication-stimulating activity

1978 • 11 citations

Synthesis of Methylglyoxal-bis-guanylhydrazone-C14

1963 • 11 citations

The Effects of 1,4-Diaminobutanone on Polyamine Metabolism in Bacteria, a Cellular Slime Mould and Rat Tissues

1978 • 10 citations

Putrescine administration reduces the rate of DNA synthesis in Ehrlich ascites tumor cells in vivo

1980 • 10 citations

The effect of anti‐spermine antibodies on a wheat germ cell‐free protein‐synthesizing system

1979 • 10 citations

Effets d'un inhibiteur de la synthese des polyamines sur la morphogenese, chez l'oursin, le chetoptere et l'algue Acetabularia

1978 • 9 citations

Ornithine decarboxylase induction in cells stimulated to proliferate differs from that in continuously dividing cells

1980 • 8 citations

Effects of polyamines and methylglyoxal bis(guanylhydrazone) on Escherichia coli ribonucleic acid polymerase and the template activity of hepatic cell nuclei in vitro

1978 • 8 citations

Effect of DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine decarboxylase, on polyamine metabolism and growth of mouse sarcoma-180.

1976 • 7 citations

Inhibition of aminopropyltransferases by S‐adenosylmethionine

1980 • 7 citations

Polyamine stimulation of in vivo rates of macromolecular synthesis in a putrescine auxotroph of Aspergillus nidulans

1978 • 7 citations

Inhibition of spermine biosynthesis and thymidine incorporation in concanavalin a transformed lymphocytes by S-adenosyl-(±)-2-methylmethionine

1980 • 7 citations

Polyamine metabolism in synchronously growing mammalian cells

1976 • 5 citations

Spectrophotometric studies on the binding with polynucleotides of 4,4'-diacetyldiphenylurea-bis(guanylhydrazone) and methylglyoxal-bis(guanylhydrazone)

1976 • 5 citations

INDUCTION OF ORNITHINE DECARBOXYLASE IN SYNCHRONIZED BHK CELLS BY CALF SERUM AFTER A SHORT PERIOD OF SERUM‐STARVATION

1978 • 2 citations