Insulin-like growth factor-I increases expression of the porcine P-450 cholesterol side chain cleavage gene through a GC-rich domain.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Lambda replacement vectors carrying polylinker sequences

1983 • 1,809 citations

The insulin signaling system.

1994 • 1,733 citations

Molecular Biology of Steroid Hormone Synthesis*

1988 • 1,387 citations

Insulin-Like Growth Factors as Intraovarian Regulators of Granulosa Cell Growth and Function*

1985 • 921 citations

Human growth hormone as a reporter gene in regulation studies employing transient gene expression.

1986 • 667 citations

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

1992 • 577 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription

1990 • 369 citations

Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.

1986 • 359 citations

Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.

1992 • 354 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Cellular mechanisms of insulin resistance in polycystic ovarian syndrome.

1992 • 325 citations

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

1987 • 292 citations

Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes

1993 • 216 citations

Gene Structure of Human Cytochrome P-450(SCC), Cholesterol Desmolase

1987 • 192 citations

Activation of ovarian sympathetic nerves in polycystic ovary syndrome.

1993 • 175 citations

Cholesterol Side-Chain Cleavage P450 Messenger Ribonucleic Acid: Evidence for Hormonal Regulation in Rat Ovarian Follicles and Constitutive Expression in Corpora Lutea*

1987 • 173 citations

Somatomedin-C Synergizes with Follicle-Stimulating Hormone in the Acquisition of Progestin Biosynthetic Capacity by Cultured Rat Granulosa Cells*

1985 • 159 citations

The Polycystic Ovary Syndrome: Pathogenesis and Treatment

1989 • 159 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

1994 • 145 citations

Insulin-like growth factor-I regulates transcription of the elastin gene

1993 • 136 citations

Trophic Actions of Human Somatomedin C/Insulin-Like Growth Factor I on Ovarian Cells:In VitroStudies with Swine Granulosa Cells*

1985 • 130 citations

Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450.

1984 • 121 citations

Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression by Insulin. Use of the Stable Transfection Approach to Locate an Insulin Responsive Sequence

1990 • 109 citations

Human P450scc Gene Transcription Is Induced by Cyclic AMP and Repressed by 12-O-Tetradecanoylphorbol-13-Acetate and A23187 through Independent cis Elements

1990 • 109 citations

Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression.

1990 • 107 citations

Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.

1990 • 107 citations

Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitro.

1990 • 99 citations

The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action

1993 • 92 citations

Insulin-Like Growth Factor Type I Increases Concentrations of Messenger Ribonucleic Acid Encoding Cytochrome P450 Cholesterol Side-Chain Cleavage Enzyme in Primary Cultures of Porcine Granulosa Cells*

1990 • 69 citations

Synergistic Actions of Estradiol and the Insulin-Like Growth Factor Somatomedin-C on Swine Ovarian (Granulosa) Cells*

1986 • 69 citations

A role for somatomedin C as A differentiating hormone and amplifier of hormone action on ovarian cells: Studies with synthetically pure human somatomedin C and swine granulosa cells

1985 • 67 citations

The roles of cAMP and cAMP-dependent Protein Kinase in the Expression of Cholesterol Side Chain Cleavage and Steroid 11β-Hydroxylase Genes in Mouse Adrenocortical Tumor Cells

1989 • 62 citations

Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 (P450scc) gene in adrenal Y1 and placental JEG-3 cells.

1994 • 62 citations

Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.

1990 • 62 citations

An Abnormality of the Growth Hormone/Insulin-Like Growth Factor-I Axis in Women with Polycystic Ovary Syndrome^*

1990 • 58 citations

Structures of regulatory regions in the human cytochrome P-450scc (desmolase) gene

1991 • 50 citations

The 5′‐flanking region of the human P‐450(SCC) gene shows responsiveness to CAMP‐dependent regulation in a transient gene‐expression system of Y‐1 adrenal tumor cells

1988 • 49 citations

Intraovarian Regulation: The Proposed Role of Insulin‐like Growth Factorsa

1993 • 47 citations

Transcriptional stimulation of the delta 1-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken.

1990 • 47 citations

Effect of insulin-like growth factor 1 on steroidogenesis in cultured human granulosa cells

1991 • 47 citations

Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin by follicle-stimulating hormone, 8-bromo-cyclic AMP, and low density lipoprotein in cultured bovine granulosa cells.

1984 • 45 citations

Nucleotide sequence of cytochrome P-450 cholesterol side-chain cleavage cDNA isolated from porcine testis

1989 • 45 citations

An element in the prolactin promoter mediates the stimulatory effect of insulin on transcription of the prolactin gene.

1992 • 43 citations

Follicle-Stimulating Hormone Increases Concentrations of Messenger Ribonucleic Acid Encoding Cytochrome P450 Cholesterol Side-Chain Cleavage Enzyme in Primary Cultures of Porcine Granulosa Cells*

1991 • 41 citations

Regulation by cyclic AMP of the genes encoding steroidogenic enzymes: when the light finally shines …

1990 • 40 citations

Definition of the ovalbumin gene promoter by transfer of an ovalglobin fusion gene into cultured cells

1983 • 37 citations

An alternative Pit-1 RNA splicing product reveals modular binding and nonmodular transcriptional activities of the POU-specific domain.

1993 • 33 citations

Regulation of expression of the CYP11A (P450scc) gene in bovine ovarian luteal cells by forskolin and phorbol esters

1993 • 33 citations

[29] Isolation of ACTH-resistant Y1 adrenal tumor cells

1985 • 31 citations

Developmental Regulation of Aortic Elastin Gene Expression Involves Disruption of an IGF-I Sensitive Repressor Complex

1993 • 29 citations

Mechanisms subserving insulin action in the gonad: Evidence that insulin induces specific phosphorylation of its immunoprecipitable receptor on ovarian cells

1984 • 25 citations

DNA binding factors which interact with the Sp1 site of the chicken δ1-crystallin promoter are developmentally regulated

1992 • 17 citations

Regulation of CYP11A gene expression in bovine ovarian granulosa cells in primary culture by cAMP and phorbol esters is conferred by a common cis-acting element

1993 • 13 citations

Similar Nuclear Factors Mediate Stimulation of Rat Thyroglobulin Gene Transcription by Thyrotropin and Insulin-Like Growth Factor-I

1990 • 9 citations

P450scc regulation in pig granulosa cells: Investigation into the mechanism of induction

1992 • 7 citations

Use of Firefly Luciferase Reporter Gene to Study Angiotensinogen Acute Phase Response Element

1991 • 6 citations

How IGF-I and IGF-I Binding Protein Can Be Modulated in Polycystic Ovarian Syndrome

1993 • 1 citations