Mutagenesis of the three bases preceding the start codon of the beta-galactosidase mRNA and its effect on translation in Escherichia coli.

Experiments in molecular genetics

1972 • 28,260 citations

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

2013 • 5,819 citations

The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites

1974 • 3,603 citations

Improved Estimation of Secondary Structure in Ribonucleic Acids

1973 • 2,302 citations

Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles

1983 • 1,256 citations

In vitro gene fusions that join an enzymatically active beta-galactosidase segment to amino-terminal fragments of exogenous proteins: Escherichia coli plasmid vectors for the detection and cloning of translational initiation signals

1980 • 1,052 citations

The tac promoter: a functional hybrid derived from the trp and lac promoters.

1983 • 1,001 citations

Translational Initiation in Prokaryotes

1981 • 785 citations

How ribosomes select initiator regions in mRNA: base pair formation between the 3' terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli.

1975 • 690 citations

Characterization of translational initiation sites inE. coli

1982 • 673 citations

Human leukocyte interferon produced by E. coli is biologically active

1980 • 528 citations

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

1979 • 517 citations

A role for mRNA secondary structure in the control of translation initiation

1982 • 344 citations

Biological Regulation and Development

1980 • 226 citations

Secondary structure of mRNA and efficiency of translation initiation

1980 • 210 citations

The ribosome binding sites recognized by E. coli ribosomes have regions with signal character in both the leader and protein coding segments

1980 • 206 citations

Promoters: Structure and function

1983 • 186 citations

Synthesis of oligonucleotides on cellulose by a phosphotriester method

1980 • 113 citations

Targeted random mutagenesis: the use of ambiguously synthesized oligonucleotides to mutagenize sequences immediately 5‘ of an ATG initiation codon

1983 • 112 citations

Increased Synthesis inE. coliof Fibroblast and Leukocyte Interferons Through Alterations in Ribosome Binding Sites

1982 • 106 citations

Complications in the simplest cellular enzyme assay: Lysis of Escherichia coli for the assay of β-galactosidase

1975 • 105 citations

Systematic alteration of the nucleotide sequence preceding the translation initiation codon and the effects on bacterial expression of the cloned SV40 small-t antigen gene

1982 • 97 citations

Portable Shine-Dalgarno Regions: A System for a Systematic Study of Defined Alterations of Nucleotide Sequences withinE. coliRibosome Binding Sites

1983 • 67 citations

Effect of the sequences upstream from the ribosome-binding site on the yield of protein from the cloned gene for phage MS2 coat protein

1983 • 60 citations

Evidence for post-transcriptional control of the morphogenetic genes of bacteriophage lambda

1974 • 60 citations

Functional inactivation of bacteriophage λ morphogenetic gene mRNA

1975 • 55 citations

Structure and function of the cy control region of bacteriophage lambda

1980 • 44 citations

Characterization of two mRNA · rRNA complexes implicated in the initiation of protein biosynthesis

1977 • 39 citations

Effect of bases contiguous to AUG on translation initiation.

1982 • 32 citations

Recognition by initiator transfer ribonucleic acid of a uridine 5' adjacent to the AUG codon: different conformational states of formylatable methionine-accepting transfer ribonucleic acid at the ribosomal peptidyl site

1981 • 29 citations

Functional Recognition of Phage RNA by 30-S Ribosomal Subunits in the Absence of Initiator tRNA

1980 • 28 citations

Involvement of Ribosomal Protein S1 in the Assembly of the Initiation Complex

1978 • 22 citations

Expression of cloned genes in prokaryotic and eukaryotic cells.

1983 • 5 citations