In vitro gene fusions that join an enzymatically active beta-galactosidase segment to amino-terminal fragments of exogenous proteins: Escherichia coli plasmid vectors for the detection and cloning of translational initiation signals

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Experiments in molecular genetics

1972 • 28,260 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid

1978 • 4,472 citations

Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA

1972 • 2,842 citations

Analysis of gene control signals by DNA fusion and cloning in Escherichia coli

1980 • 2,499 citations

Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu

1976 • 1,895 citations

Complete Nucleotide Sequence of the Escherichia coli Plasmid pBR322

1979 • 1,807 citations

Construction of Biologically Functional Bacterial Plasmids In Vitro

1973 • 1,699 citations

Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis

1973 • 1,616 citations

Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis

1975 • 1,135 citations

Construction and characterization of new cloning vehicles I. Ampicillin-resistant derivatives of the plasmid pMB9

1977 • 1,055 citations

Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequences.

1979 • 940 citations

Expression in Escherichia coli of a Chemically Synthesized Gene for the Hormone Somatostatin

1977 • 829 citations

Expression in Escherichia coli of chemically synthesized genes for human insulin.

1979 • 813 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1964 • 720 citations

How the λ repressor and cro work

1980 • 452 citations

Construction of plasmids carrying the cI gene of bacteriophage lambda.

1976 • 410 citations

Specificity of substrate recognition by the EcoRI restriction endonuclease.

1975 • 313 citations

Use of gene fusion to study secretion of maltose-binding protein into Escherichia coli periplasm

1979 • 267 citations

Biochemical method for mapping mutational alterations in DNA with S1 nuclease: the location of deletions and temperature-sensitive mutations in simian virus 40.

1975 • 264 citations

Lac repressor can be fused to β-galactosidase

1974 • 206 citations

Molecular basis of beta-galactosidase alpha-complementation.

1975 • 190 citations

The amino acid sequence of beta-galactosidase of Escherichia coli.

1977 • 176 citations

Cloning and characterization of EcoRI and HindIII restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6

1978 • 166 citations

A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli

1973 • 149 citations

Use of gene fusions to study outer membrane protein localization in Escherichia coli.

1977 • 148 citations

A general method for inserting specific DNA sequences into cloning vehicles

1976 • 113 citations

Transposition protein of Tn3: identification and characterisation of an essential represser-controlled gene product

1979 • 112 citations

Conversion of beta-galactosidase to a membrane-bound state by gene fusion.

1976 • 100 citations

Genetic fusions defining trp and lac operon regulatory elements

1975 • 86 citations

Identification and characterization of a self-regulated repressor of translocation of the Tn3 element.

1979 • 83 citations

Fusion of the Escherichia coli lac genes to the ara promoter: a general technique using bacteriophage Mu-1 insertions.

1975 • 73 citations

Synthesis of an ovalbumin-like protein by Escherichia coli K12 harbouring a recombinant plasmid

1978 • 71 citations

Construction, Isolation and Implications of Repressor‐galactosidase ·ß‐galactosidase Hybrid Molecules

1977 • 61 citations

[15a] Purification and detection of reverse transcriptase in viruses and cells

1974 • 59 citations

Genetic Fusions of the lac Operon: A New Approach to the Study of Biological Processes

1980 • 54 citations

Inhibition of lacZ Gene Translation Initiation in trp-lac Fusion Strains

1974 • 48 citations

Use of gene fusions to determine a partial signal sequence of alkaline phosphatase

1979 • 41 citations

Regulated expression by readthrough translation from a plasmid-encoded beta-galactosidase

1978 • 37 citations

Positions of early nonsense and deletion mutations in lacZ

1980 • 31 citations

Chemical synthesis of versatile adaptors for molecular cloning

1978 • 31 citations

Studies of the Specificity and Control of Transposition of the Tn3 Element

1979 • 23 citations

Synthetic multifunctional proteins

1977 • 10 citations

DNA CLONING AND PLASMID BIOLOGY

1977 • 6 citations

UseofGeneFusions toDetermine aPartial Signal Sequence ofAlkaline Phosphatase

1979 • 1 citations

Deleted Work

1955 • 0 citations