c-Myc Dependent Initiation of Genomic Instability During Neoplastic Transformation

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

GENE AMPLIFICATION

1984 • 580 citations

Engineering Herbicide Tolerance in Transgenic Plants

1986 • 523 citations

Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

1983 • 504 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1993 • 246 citations

Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.

1994 • 227 citations

Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability

1994 • 218 citations

DNA amplification is rare in normal human cells.

1990 • 192 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

1992 • 187 citations

Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

1990 • 179 citations

Regulation and Mechanisms of Mammalian Gene Amplification

1993 • 163 citations

Amplification enhancers and replication origins in the autosomal chorion gene cluster of Drosophila.

1989 • 161 citations

Regulation of cell cycle duration by c-myc levels.

1989 • 155 citations

An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence.

1992 • 147 citations

Effects of c-myc Expression on Cell Cycle Progression

1994 • 141 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc.

1994 • 127 citations

Overexpression of cyclin D1 enhances gene amplification.

1996 • 114 citations

Elevated c-myc expression facilitates the replication of SV40 DNA in human lymphoma cells

1987 • 108 citations

Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting.

1983 • 106 citations

Effects of c-myc expression on cell cycle progression.

1994 • 93 citations

Genomic instability in MycER-activated Rat1A-MycER cells

1996 • 88 citations

De novo amplification within a "silent" human cholinesterase gene in a family subjected to prolonged exposure to organophosphorous insecticides.

1989 • 84 citations

c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines.

1996 • 79 citations

Amplification of cellular oncogenes in cancer cells

1985 • 76 citations

MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.

1994 • 71 citations

Ionizing radiation damage to DNA: Molecular aspects

1989 • 60 citations

Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc.

1991 • 59 citations

Protein-DNA Interactions at the Major and Minor Promoters of the Divergently Transcribed dhfr and rep3 Genes during the Chinese Hamster Ovary Cell Cycle

1996 • 55 citations

Overexpression of c-myc precedes amplification of the gene encoding dihydrofolate reductase

1994 • 49 citations

C-Myc binds to 5′ flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation

1994 • 47 citations

The c-myc protein represses the λ5 and TdT initiators

1995 • 43 citations

Origin of adeno-associated virus DNA replication is a target of carcinogen-inducible DNA amplification

1991 • 33 citations

Replication and transcription in the course of DNA amplification of the C3 and C8 DNA puffs of Rhynchosciara americana

1991 • 27 citations

Fibroblast growth factor mediated alterations in drug resistance, and evidence of gene amplification.

1994 • 23 citations

The DNA region around the c-myc gene and its amplification in human tumour cell lines.

1994 • 22 citations

UV-induced early-domain binding factor as the limiting component of simian virus 40 DNA amplification in rodent cells.

1989 • 21 citations

Permissivity for methotrexate-induced DHFR gene amplification correlates with the metastatic potential of rat adenocarcinoma cells

1994 • 18 citations

Aberrant Expression of Basic Fibroblast Growth Factor in NIH-3T3 Cells Alters Drug Resistance and Gene Amplification Potential

1994 • 16 citations

Drug resistance and gene amplification potential regulated by transforming growth factor beta 1 gene expression.

1995 • 13 citations

The effect of myc proteins on SV40 replication in human lymphoid cells.

1990 • 12 citations

Analysis of c-Myc domains involved in stimulating SV40 replication

1993 • 10 citations

Review: gene amplification--a cellular response to genotoxic stress.

1989 • 9 citations

Amplified extrachromosomal elements containing c-Myc and Pvt 1 in a mouse plasmacytoma

1995 • 7 citations

SV40 DNA Amplification and Reintegration in Surviving Hamster Cells after⁶⁰Co γ-irradiation

1990 • 7 citations