RNA 3' END FORMATION IN THE CONTROL OF GENE EXPRESSION

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

TRANSCRIPTION TERMINATION AND THE REGULATION OF GENE EXPRESSION

1986 • 811 citations

Termination Factor for RNA Synthesis

1969 • 801 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Nucleotide sequences in Xenopus 5S DNA required for transcription termination

1981 • 515 citations

COMPLEX TRANSCRIPTIONAL UNITS: DIVERSITY IN GENE EXPRESSION BY ALTERNATIVE RNA PROCESSING

1986 • 486 citations

Small RNA species of the HeLa cell: Metabolism and subcellular localization

1976 • 409 citations

The relationship between function and DNA sequence in an intercistronic regulatory region in phage λ

1978 • 361 citations

Intragenic pausing and anti-sense transcription within the murine c-myc locus.

1986 • 326 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression

1986 • 254 citations

U6 small nuclear RNA is transcribed by RNA polymerase III.

1986 • 250 citations

Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3′ end processing in the human alpha 2 globin gene.

1986 • 236 citations

Transcription termination factor rho is an RNA-DNA helicase

1987 • 234 citations

Pausing and termination of transcription within the early region of bacteriophage T7 DNA in vitro.

1981 • 229 citations

Site-specific polyadenylation in a cell-free reaction

1984 • 223 citations

3′ end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters

1986 • 222 citations

Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element

1986 • 215 citations

Release of Polarity in Escherichia coli by Gene N of Phage λ: Termination and Antitermination of Transcription

1974 • 201 citations

Thalassemia due to a mutation in the cleavage-polyadenylation signal of the human beta-globin gene.

1985 • 195 citations

Transcription of mouse rDNA terminates downstream of the 3′ end of 28S RNA and involves interaction of factors with repeated sequences in the 3′ spacer

1985 • 189 citations

Formation of the 3′ end of U1 snRNA is directed by a conserved sequence located downstream of the coding region.

1985 • 183 citations

Purified RNA polymerase III accurately and efficiently terminates transcription of 5s RNA genes

1983 • 179 citations

Studies of novel transducing variants of lambda: Dispensability of genes N and Q

1969 • 174 citations

Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site

1985 • 156 citations

A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter

1986 • 153 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination

1986 • 143 citations

A transcriptional terminator is a novel element of the promoter of the mouse ribosomal RNA gene

1986 • 136 citations

Purification and properties of a soluble factor required for the deoxyribonucleic acid-directed in vitro synthesis of beta-galactosidase.

1975 • 132 citations

Termination of transcription by nusA gene protein of Escherichia coli

1981 • 130 citations

Lytic Mode of Lambda Development

1983 • 127 citations

Bacterial Mutants in Which the Gene N Function of Bacteriophage Lambda Is Blocked Have an Altered RNA Polymerase

1971 • 126 citations

Sequences required for 3′ end formation of human U2 small nuclear RNA

1985 • 122 citations

nusA Protein of Escherichia coli is an efficient transcription termination factor for certain terminator sites

1987 • 121 citations

Activation of rho protein ATPase requires simultaneous interaction at two kinds of nucleic acid-binding sites.

1982 • 121 citations

Effects of alterations in the 3′ flanking sequence on in vivo and in vitro expression of the yeast SUP4-o tRNATyr gene.

1985 • 115 citations

Evidence that a nucleotide sequence, “boxA,” is involved in the action of the NusA protein

1983 • 114 citations

Intracellular site of U1 small nuclear RNA processing and ribonucleoprotein assembly.

1984 • 114 citations

Pausing of RNA polymerase during in vitro transcription of the tryptophan operon leader region

1981 • 109 citations

Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation.

1984 • 109 citations

Tandem termination sites in the tryptophan operon of Escherichia coli.

1981 • 105 citations

Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse β-globin (major) gene

1984 • 98 citations

Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre-mRNA in the oocyte.

1986 • 96 citations

Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA.

1985 • 93 citations

Transcriptional controls in developing bacteriophages

1969 • 91 citations

Transcription antitermination in vitro by lambda N gene product: Requirement for a phage nut site and the products of host nusA, nusB, and nusE genes

1984 • 82 citations

Control of transcription termination: A rho-dependent termination site in bacteriophage lambda

1980 • 73 citations

Interaction of RNA polymerase and rho in transcription termination: coupled ATPase.

1978 • 73 citations

Binding of rho factor to Escherichia coli RNA polymerase mediated by nusA protein.

1984 • 67 citations

The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications.

1983 • 67 citations

Role of leader peptide synthesis in tryptophanase operon expression in Escherichia coli K-12

1986 • 64 citations

Formation of low molecular weight RNA species in HeLa cells

1980 • 64 citations

The nusA recognition site

1984 • 64 citations

Mutations downstream of the polyadenylation site of a Xenopus β-globin mRNA affect the position but not the efficiency of 3′ processing

1986 • 63 citations

Transcription of the Mouse Dihydrofolate Reductase Gene Proceeds Unabated Through Seven Polyadenylation Sites and Terminates Near a Region of Repeated DNA

1984 • 63 citations

Formation of the 3′ end on U snRNAs requires at least three sequence elements.

1986 • 58 citations

Transcription termination at λ tR1 is mediated by interaction of rho with specific single-stranded domains near the 3′ end of cro mRNA

1986 • 57 citations

Controls of rightward transcription in coliphage λ

1970 • 56 citations

Regulation of the Transcription of Escherichia coli Phage by Its Early Genes N and tof

1970 • 49 citations

Transcription unit of the rabbit beta 1 globin gene.

1985 • 48 citations

Regulatory defects of a conditionally lethal nusAts mutant of Escherichia coli

1986 • 45 citations

Biosynthesis of small nuclear RNAs in human cells

1983 • 44 citations

Mutants of satellite bacteriophage P4 that are defective in the suppression of transcriptional polarity

1981 • 42 citations

RNA polymerase II transcription terminates at a specific DNA sequence in a HeLa cell-free reaction.

1986 • 42 citations

Transcription in vitro of bacteriophage lambda 4S RNA: studies on termination and rho protein

1977 • 41 citations

Escherichia coli nusB mutations that suppress nusA1 exhibit λ N specificity

1983 • 39 citations

Transcription unit mapping in adenovirus: regions of termination

1986 • 38 citations

Attenuation May Regulate Gene Expression in Animal Viruses and Cell

1985 • 38 citations

Rho-dependent termination and concomitant NTPase activity requires a specific, intact RNA region.

1984 • 36 citations

Role of the Gene N Product in Phage Lambda

1970 • 36 citations

A mutation in the Escherichia coli rho gene that inhibits the N protein activity of phage

1983 • 34 citations

N-Independent leftward transcription in coliphage lambda: Deletions, insertions and new promoters bypassing termination functions

1979 • 34 citations

rho Factors from polarity suppressor mutants with defects in their RNA interactions.

1982 • 34 citations

E. coli NusA protein binds in vitro to an RNA sequence immediately upstream of the boxA signal of bacteriophage lambda.

1985 • 31 citations

nusB: a protein factor necessary for transcription antitermination in vitro by phage lambda N gene product.

1984 • 29 citations

Detection of transcription-pausing in vivo in the trp operon leader region.

1987 • 29 citations

Transcription termination factor rho mediates simultaneous release of RNA transcripts and DNA template from complexes with Escherichia coli RNA polymerase.

1985 • 28 citations

Revised sequence of the nusA gene of Escherichia coli and identification of nusA11 (ts) and nusA1 mutations which cause changes in a hydrophobic amino acid cluster

1986 • 28 citations

The Activity of Salmonella phage P22 gene 24 product in Escherichia coli

1978 • 28 citations

Mapping of the Q-utilization site (qut) required for antitermination of late transcription in bacteriophage lambda

1983 • 27 citations

Fidelity of in Vitro Transcription of T3 Deoxyribonucleic Acid by Bacteriophage T3-induced Ribonucleic Acid Polymerase and by Escherichia coli Ribonucleic Acid Polymerase

1974 • 26 citations

Studies on the E. coli groNB (nusB) gene which affects bacteriophage λ N gene function

1980 • 25 citations

Transcription terminator involved in the expression of the int gene of phage lambda

1984 • 24 citations

Polyadenylylation of an mRNA precursor occurs independently of transcription by RNA polymerase II in vivo.

1986 • 24 citations

The functional boundaries of the Q-utilization site required for antitermination of late transcription in bacteriophage λ

1987 • 16 citations

The sequence of the distal end of theE. coliribosomal RNA rrnE operon indicates conserved features are shared by rrn operons

1985 • 16 citations

Globin gene transcripts can utilize histone gene 3′ end processing signals

1986 • 16 citations

Transcriptional antitermination activity of the synthetic nut elements of coliphage lambda I. Assembly of thenutR recognition site from boxA and nut core elements

1986 • 8 citations