Antioxidants-Carcinogenic and Chemopreventive Properties

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Can dietary beta-carotene materially reduce human cancer rates?

1981 • 1,575 citations

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

1980 • 1,277 citations

Salmonella mutagenicity test results for 250 chemicals

1983 • 902 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds

1976 • 594 citations

Carcinogenicity of Butylated Hydroxyanisole in F344 Rats<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1983 • 574 citations

PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER

1983 • 556 citations

Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer

1986 • 542 citations

Studies on antioxidants: Their carcinogenic and modifying effects on chemical carcinogenesis

1986 • 520 citations

Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound

1981 • 510 citations

Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N -Nitroso Compounds

1972 • 506 citations

Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats—an approach for a new medium-term bioassay system

1988 • 403 citations

Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin<xref ref-type="fn" rid="FN2">2</xref>

1972 • 352 citations

Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2

1976 • 344 citations

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA

1987 • 343 citations

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

1978 • 338 citations

Carcinogenicity and Modification of the Carcinogenic Response by bha, Bht, and Other Antioxidants

1985 • 331 citations

Antioxidants and Cancer

1976 • 329 citations

Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data.

1985 • 322 citations

Inhibition of Chemical Carcinogenesis

1978 • 321 citations

Antitumor Activity of <i>β</i>-Carotene, Canthaxanthin and Phytoene

1982 • 311 citations

Inhibitors of Chemical Carcinogenesis

1978 • 304 citations

Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea

1987 • 291 citations

Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats

1983 • 272 citations

Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum).

1980 • 271 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acid

1982 • 269 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

Relationship of Selenium to Cancer. I. Inhibitory Effect of Selenium on Carcinogenesis

1970 • 259 citations

Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase

1983 • 256 citations

The tumor-promoting action of phenol and related compounds for mouse skin.

1959 • 244 citations

Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23

1974 • 240 citations

Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer

1986 • 238 citations

Gastric Cancer in Colombia. I. Cancer Risk and Suspect Environmental Agents2

1976 • 236 citations

Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

1984 • 233 citations

Plasma retinol, β-carotene and vitamin E levels in relation to the future risk of breast cancer

1984 • 229 citations

Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia.

1980 • 224 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.

1977 • 201 citations

Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

1979 • 200 citations

Role of Selenium in The Chemoprevention of Cancer

1979 • 193 citations

Lung injury induced by butylated hydroxytoluene: cytodynamic and biochemical studies in mice.

1977 • 186 citations

Inhibition of experimental oral carcinogenesis by topical beta carotene

1986 • 185 citations

Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice.

1988 • 185 citations

The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice

1986 • 181 citations

Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of breast cancer

1988 • 180 citations

Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review.

1977 • 177 citations

Role of oxygen radicals in tumor promotion

1984 • 176 citations

Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan.

1988 • 175 citations

Carcinogenicity examination of quercetin and rutin in ACI rats

1981 • 175 citations

Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice

1983 • 171 citations

Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors

1977 • 168 citations

Inhibition of Chemical Carcinogen-Induced Pulmonary Neoplasia by Butylated Hydroxyanisole

1973 • 167 citations

Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats

1973 • 157 citations

Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats.

1983 • 157 citations

Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens.

1986 • 153 citations

Increase of sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites.

1980 • 151 citations

Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration

1982 • 146 citations

Diminution of mouse epidermal superoxide dismutase and catalase activities by tumor promoters

1981 • 144 citations

Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide.

1986 • 144 citations

Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat

1977 • 138 citations

Induction of Mouse Lung Adenomas by Amines or Ureas Plus Nitrite and by N-Nitroso Compounds: Effect of Ascorbate, Gallic Acid, Thiocyanate, and Caffeine2

1975 • 136 citations

Dose-response studies on the carcinogenicity of potassium bromate in F344 rats after long-term oral administration.

1986 • 128 citations

Enhancement of Urethan Tumorigenesis in Mouse Lung by Butylated Hydroxytoluene2

1977 • 127 citations

Possible cocarcinogenic effects of coffee constituents

1975 • 124 citations

Oral Mucosal Carcinogenesis in Hamsters: Inhibition by Vitamin E<xref ref-type="fn" rid="fn2">2</xref>

1982 • 120 citations

Caffeic and ferulic acid as blockers of nitrosamine formation

1984 • 116 citations

Test of carcinogenicity of quercetin, a widely distributed mutagen in food

1981 • 114 citations

Dose-related inhibition of aflatoxin B₁ induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene

1986 • 113 citations

Toxicology of tert-butylhydroquinone (TBHQ)

1986 • 109 citations

Naturally Occurring Phenolics as Antimutagenic and Anticarcinogenic Agents

1984 • 108 citations

Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (±)-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse

1985 • 107 citations

Results from 86 two‐year carcinogenicity studies conducted by the national toxicology program

1984 • 106 citations

Toxicology of gallates: A review and evaluation

1986 • 106 citations

Inhibitory effect of chlorogenic acid on methylazoxymethanol acetate-induced carcinogenesis in large intestine and liver of hamsters

1986 • 105 citations

Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine

1984 • 104 citations

Enhancement of Glutathione <italic>S</italic>-Transferase Activity of the Mouse Forestomach by Inhibitors of Benzo[<italic>a</italic>]pyrene-Induced Neoplasia of the Forestomach<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 104 citations

Inhibitory effects of glutathione level-raising agents and D-α-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

1985 • 102 citations

Estimation of dietary intake of nitrate and nitrate in Great Britain

1987 • 101 citations

Effect of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in mice

1979 • 99 citations

Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.

1985 • 98 citations

Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin.

1987 • 98 citations

Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane

1977 • 96 citations

Effect of retinoic acid, butylated hydroxytoluene, selenium and sorbic acid on azo-dye hepatocarcinogenesis

1980 • 96 citations

Developments in the epidemiology of stomach cancer over the past decade.

1975 • 94 citations

Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate.

1983 • 93 citations

Ellagic acid binding to DNA as a possible mechanism for its antimutagenic and anticarcinogenic action

1986 • 91 citations

Polyamine biosynthesis and skin tumor promotion: Inhibition of 12-0-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase α-difluoromethylornithine

1982 • 90 citations

Carcinogenicity study on butylated hydroxytoluene (BHT) in Wistar rats exposed in utero

1986 • 89 citations

Uracil-induced urolithiasis and the development of reversible papillomatosis in the urinary bladder of F344 rats.

1986 • 88 citations

Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water.

1986 • 86 citations

Effect of an inorganic and organic form of dietary selenium on the promotional stage of mammary carcinogenesis in the rat.

1984 • 85 citations

Are free radicals involved in tumor promotion?

1985 • 85 citations

Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.

1978 • 83 citations

Effect of Vitamin E on Carcinogenicity of Methylcholanthrene.

1962 • 83 citations

Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters

1987 • 83 citations

Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters

1986 • 82 citations

Selenium-mediated inhibition of 7,12-dimethylbenz[a]anthracene-induced mouse mammary tumorigenesis

1981 • 82 citations

Selenium Inhibition of <italic>N</italic>-Methyl-<italic>N</italic>-nitrosourea-Induced Mammary Carcinogenesis in the Rat<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>, <xref ref-type="fn" rid="fn4">4</xref>

1980 • 81 citations

Dose Response in Butylated Hydroxyanisole Induction of Forestomach Carcinogenesis in F344 Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1986 • 81 citations

Formation of a mutagenic diazoquinone by interaction of phenol with nitrite

1988 • 81 citations

Prevention by Vitamin E of Experimental Oral Carcinogenesis2

1987 • 80 citations

Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine

1984 • 80 citations

Factors influencing the anticarcinogenic efficacy of selenium in dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats.

1981 • 79 citations

Protective Effect of β-Carotene Against Colon Tumors in Mice<xref ref-type="fn" rid="FN2">2</xref>

1987 • 79 citations

Chronic toxicity of butylated hydroxytoluene in Wistar rats

1981 • 78 citations

Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats.

1981 • 77 citations

Effect of ellagic acid on hepatic and pulmonary xenobiotic metabolism in mice: studies on the mechanism of its anticarcinogenic action

1985 • 77 citations

Effects of BHA and related phenols on the forestomach of rats

1986 • 77 citations

Enhancing Effect of Vitamin E on Murine Intestinal Tumorigenesis by 1 ,2-Dimethylhydrazine Dihydrochloride<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 77 citations

Rapid Nitrosation of Phenols and its Implications for Health Hazards from Dietary Nitrites

1973 • 77 citations

Short-term pathological and proliferative effects of butylated hydroxyanisole and other phenolic anti-oxidants in the forestomach of Fischer 344 rats

1984 • 75 citations

The Pharmacological Evaluation of Antioxidants

1951 • 74 citations

Influence of ascorbic acid dose on N-nitrosoproline formation in humans

1987 • 74 citations

Anticarcinogenic effect of selenium in rats treated with dimethylbenz[a]anthracene and fed different levels and types of fat

1981 • 74 citations

Relationship of Dietary Selenium Concentration; Chemical Cancer Induction; and Tissue Concentration of Selenium in Rats

1973 • 73 citations

Dietary factors and the etiology of gastric cancer.

1975 • 73 citations

Ornithine decarboxylase activity, cell proliferation, and tumor promotion in mouse epidermis in vivo.

1979 • 73 citations

Effects of Butylated Hydroxyanisole, Butylated Hydroxytoluene, and NaCl on Gastric Carcinogenesis Initiated With <italic>N</italic>-Methyl-<italic>N</italic>'-nitro-<italic>N</italic>-nitrosoguanidine in F344 Rats<xref ref-type="fn" rid="FN2">2</xref>

1984 • 72 citations

Inhibition of polycyclic aromatic hydrocarbon-DNA adduct formation in epidermis and lungs of SENCAR mice by naturally occurring plant phenols.

1987 • 72 citations

Alterations in Microsomal Metabolism of Benzo [&lt;italic&gt;a&lt;/italic&gt;] pyrene in Mice Fed Butylated Hydroxyanisole&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;

1975 • 72 citations

Tissue-specific induction patterns of cancer-protective enzymes in mice by tert-butyl-4-hydroxyanisole and related substituted phenols.

1985 • 70 citations

Ascorbic acid and the formation of N-nitroso compounds: possible role of ascorbic acid in cancer prevention

1987 • 70 citations

TOWARD A DIETARY PREVENTION OF CANCER1

1983 • 69 citations

Regression by vitamin E of experimental oral cancer.

1987 • 69 citations

Effects of organoselenium compounds on induction of mouse forestomach tumors by benzo(a)pyrene.

1985 • 68 citations

Short-term effects of various phenols and acids on the fischer 344 male rat forestomach epithelium

1986 • 68 citations

Butylated hydroxyanisole-stimulated NADPH oxidase activity in rat liver microsomal fractions.

1983 • 68 citations

Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin

1985 • 67 citations

Histopathological and radioautographical studies on the forestomach of F344 rats treated with butylated hydroxyanisole and related chemicals

1986 • 67 citations

Vitamin A, carotenoids, and retinoids

1986 • 64 citations

Ellagic acid: a potent naturally occurring inhibitor of benzo[a]pyrene metabolism and its subsequent glucuronidation, sulfation and covalent binding to DNA in cultured BALB/C mouse keratinocytes

1984 • 64 citations

Effect of selenium on azoxymethane-induced intestinal cancer in rats fed high fat diet

1981 • 64 citations

Quercetin: A mutagen, not a carcinogen, in fischer rats

1984 • 63 citations

Epigenetic promoting effects of butylated hydroxyanisole

1986 • 63 citations

d,1-alpha-Tocopheryl acetate (vitamin E): a long term toxicity and carcinogenicity study in rats.

1983 • 60 citations

Metabolism of 3-tert-butyl-4-hydroxyanisole by microsomal fractions and isolated rat hepatocytes.

1985 • 60 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinogenesis by concomitant or postcarcinogen antioxidant exposure.

1984 • 59 citations

Inhibition of estrogen-induced renal carcinoma in Syrian hamsters by vitamin C.

1983 • 58 citations

Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.

1988 • 58 citations

A 13-week feeding study of butylated hydroxyanisole: The subsequent regression of the induced lesions in male fischer 344 rat forestomach epithelium

1985 • 58 citations

Inhibition by plant phenols of benzo[a]pyrene-induced nuclear aberrations in mammalian intestinal cells: A rapid in vivo assessment method

1985 • 57 citations

Hepatocellular Tumorigenicity of Butylated Hydroxytoluene Administered Orally to B6C3F₁ Mice

1988 • 57 citations

Induction of early lesions in the forestomach of rats by 3-tert-butyl-4-hydroxyanisole (BHA)

1985 • 55 citations

Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B₁

1987 • 55 citations

Food Additives Metabolism, Fate of Butylated Hydroxyanisole in Man and Dog

1962 • 54 citations

Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N,N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats.

1987 • 54 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway

1982 • 53 citations

On the role of superoxide anion radicals in skin tumour promotion

1984 • 53 citations

Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol

1984 • 52 citations

Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats

1984 • 52 citations

CARCINOGENICITY TEST OF QUERCETIN AND KAEMPFEROL IN RATS BY ORAL ADMINISTRATION

1983 • 52 citations

Effect of vitamins C and E on endogenous synthesis of N-nitrosamino acids in humans: precursor-product studies with [15N]nitrate.

1985 • 52 citations

Lack of carcinogenicity of butylated hydroxytoluene on long-term administration to b6c3f1 mice

1982 • 52 citations

Induction of Cancer of the Glandular Stomach in Rats by an Extract of Nitrite-Treated Fish&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;

1980 • 52 citations

Catalysis of nitrosation in vitro and in vivo in rats by catechin and resorcinol and inhibition by chlorogenic acid

1982 • 52 citations

Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats

1988 • 52 citations

Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole.

1981 • 51 citations

Quantitative analysis of catechol and 4-methylcatechol in human urine

1982 • 50 citations

Selenium and the genesis of murine mammary tumors

1981 • 50 citations

Excretion of butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) by man

1967 • 50 citations

In vitro metabolism of 3-t-butyl-4-hydroxyanisole and its irreversible binding to proteins

1983 • 49 citations

Enhancement of Lung Tumor Formation in Mice by Dietary Butylated Hydroxy toluene: Dose-Time Relationships and Cell Kinetics&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1983 • 49 citations

Inhibition of epidermal metabolism and DNA-binding of benzo[a]pyrene by ellagic acid

1983 • 48 citations

Inhibitory effect of phenolic compounds on aflatoxin B1 metabolism and induced mutagenesis

1987 • 47 citations

Pharmacologic and Genetic Studies on the Modulatory Effects of Butylated Hydroxytoluene on Mouse Lung Adenoma Formation&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;

1984 • 47 citations

Inhibitory Effects of Butylated Hydroxyanisole on Methylazoxymethanol Acetate-Induced Neoplasia of the Large Intestine and on Nicotinamide Adenine Dinucleotide-Dependent Alcohol Dehydrogenase Activity in Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;

1979 • 47 citations

Simultaneous inhibition of liver carcinogenicity and enhancement of bladder carcinogenicity of N-2-fluorenylacetamide by butylated hydroxytoluene

1983 • 46 citations

Cabbage and vitamin E: Their effect on colon tumor formation in mice

1987 • 46 citations

Promoting effect of 4-dimethylaminoazobenzene on enzyme altered foci induced in rat liver by N-nitrosodiethanolamine

1984 • 45 citations

Metabolism of 3-tert-butyl-4-hydroxyanisole to 3-tert-butyl-4,5-dihydroxyanisole by rat liver microsomes.

1985 • 45 citations

Effect of dietary sodium ascorbate on 1,2-dimethylhydrazine- or methylnitrosourea-induced colon carcinogenesis in rats

1982 • 45 citations

Long-term toxicity study of n-propyl gallate in mice

1974 • 44 citations

The metabolism of butylated hydroxyanisole in the rabbit

1956 • 44 citations

Inhibition of chemically induced mammary carcinogenesis in rats by long-term exposure to butylated hydroxytoluene (BHT): interrelations among BHT concentration, carcinogen dose, and diet.

1986 • 42 citations

Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats

1985 • 42 citations

Neoplastic Effects of Oral Administration of (±)-&lt;italic&gt;trans&lt;/italic&gt;-7 ,8-Dihydroxy-7,8-dihydrobenzo[&lt;italic&gt;a&lt;/italic&gt;]pyrene and Their Inhibition by Butylated Hydroxyanisole&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1979 • 41 citations

Modification by antioxidants and p, p'-diaminodiphenylmethane of 7, 12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats

1986 • 41 citations

Effect of quercetin on two-stage carcinogenesis of the rat urinary bladder

1983 • 41 citations

Effects of four antioxidants on N-methyl-N′-nitro-N-nitrosoguanidine initiated gastric tumor development in rats

1986 • 40 citations

Selective Protective Effect of Butylated Hydroxytoluene Against 1,2-Dimethylhydrazine Carcinogenesis in BALB/c Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1979 • 40 citations

Intake of phenolic antioxidants from foods in Canada

1986 • 40 citations

An 85-day study of butylated hydroxyanisole in the cynomolgus monkey

1985 • 40 citations

Oxidation of 2-t-butyl-4-methoxyphenol (BHA) by horseradish and mammalian peroxidase systems

1980 • 40 citations

Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis

1986 • 39 citations

Test of Catechol, Tannic Acid, &lt;italic&gt;Bidens pilosa&lt;/italic&gt;, Croton Oil, and Phorbol for Cocarcinogenesis of Esophageal Tumors Induced in Rats by Methyl-&lt;italic&gt;n&lt;/italic&gt;-amylnitrosamine&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1985 • 39 citations

DNA breakage by phenyl compounds.

1985 • 37 citations

Separation of early diffuse alveolar cell proliferation from enhanced tumor development in mouse lung.

1986 • 36 citations

Modifying Effects of Antioxidants on Chemical Carcinogenesis

1986 • 36 citations

The metabolism of phenolic antioxidants. 2. The metabolism of butylated hydroxyanisole in the rat

1960 • 36 citations

Effects of strain and age on prophylaxis and co-carcinogenesis of urethan-induced mouse lung adenomas by butylated hydroxytoluene.

1986 • 36 citations

Modification by α-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine

1987 • 36 citations

Dose-Response Studies of the Effect of Dietary Butylated Hydroxyanisole on Colon Carcinogenesis Induced by Methylazoxymethanol Acetate in Female CF1 Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1984 • 35 citations

Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase

1985 • 34 citations

Ellagic acid metabolism and binding to DNA in organ explant cultures of the rat

1987 • 34 citations

Feasibility of using lower doses of chemopreventive agents in a combination regimen for cancer protection

1988 • 34 citations

N-nitrosation and N-nitration of morpholine by nitrogen dioxide: Inhibition by ascorbate, glutathione and α-tocopherol

1986 • 34 citations

Selective Sex-Related Modification of Diethylnitrosamine-lnduced Carcinogenesis in BALB/c Mice by Concomitant Administration of Butylated Hydroxytoluene2

1978 • 34 citations

The Urinary Excretion of Trittated Butylated Hydroxyanisole and Butylated Hydroxytoluene in the Rat

1962 • 34 citations

Studies related to the mechanism of 3-BHA-induced neoplasia of the rat forestomach

1986 • 33 citations

Mechanism of inhibition of N-methyl-N′-nitro-N-nitrosoguanidine-induced mutagenesis by phenolic compounds

1986 • 33 citations

Free Radical Injury and Liver Tumor Promotion

1987 • 33 citations

Six-month toxicity study of butylated hydroxyanisole in beagle dogs

1986 • 33 citations

Effects of 2- and 3-tert-butyl-4-hydroxyanisole on glutathione S-transferase and epoxide hydrolase activities and sulfhydryl levels in liver and forestomach of mice.

1981 • 32 citations

Effect of dietary excess of inorganic selenium during initiation and postinitiation phases of colon carcinogenesis in F344 rats.

1988 • 31 citations

Inhibitory effect of dietary selenium on carcinogenesis in rat glandular stomach induced by N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 31 citations

Adenoma Development in Mouse Lung Following Treatment with Possible Promoting Agents

1982 • 31 citations

Caffeic acid as an inhibitor of DMBA-induced chromosomal breakage in mice assessed by bone-marrow micronucleus test

1983 • 30 citations

2,2'-dihydroxy-3,3'-di-t-butyl-5,5'-dimethoxydiphenyl, a new metabolite of 2-t-butyl-4-methoxyphenol in the rat.

1983 • 30 citations

Protective effect of butylated hydroxytoluene against induction of gastric cancer by N‐methyl‐N′‐nitro‐N‐nitrosoguanidine in wistar rats

1983 • 29 citations

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (II): Metabolism in forestomach and covalent binding to tissue macromolecules

1987 • 29 citations

A new metabolite of butylated hydroxyanisole in man

1983 • 29 citations

Chronic feeding studies of butylated hydroxyanisole in dogs

1964 • 29 citations

Skin-tumour promoting activity of methyl ethyl ketone peroxide—a potent lipid-peroxidizing agent

1984 • 29 citations

Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice.

1986 • 28 citations

Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomatch hyperplasia - complete inhibition by diethylmaletate in a 5-week feeding study

1987 • 28 citations

Effect of subchronic dietary administration of butylated hydroxyanisole on canine stomach and hepatic tissue

1986 • 27 citations

Chemoprevention of Colorectal Neoplasms

1986 • 27 citations

Inhibitory Effect of Dietary &lt;italic&gt;p&lt;/italic&gt;-Methoxybenzeneselenol on Azoxymethane-Induced Colon and Kidney Carcinogenesis in Female F344 Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;

1985 • 27 citations

Histologic and Autoradiographic Studies on the Forestomach of Hamsters Treated With 2-&lt;italic&gt;tert&lt;/italic&gt;-Butylated Hydroxyanisole, 3-&lt;italic&gt;tert&lt;/italic&gt;-Butylated Hydroxyanisole, Crude Butylated Hydroxyanisole, or Butylated Hydroxytoluene&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1986 • 26 citations

Modulation by plant flavonoids and related phenolics of microsome catalyzed adduct formation between benzo[a]Pyrene and DNA

1986 • 26 citations

Liver and Forestomach Tumors and Other Forestomach Lesions in Rats Treated With Morpholine and Sodium Nitrite, With and Without Sodium Ascorbate&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1983 • 24 citations

Gastric carcinogenesis: A model for the identification of risk factors

1987 • 24 citations

Chemical Cocarcinogenesis With the Use of a Subclone Derived From Balb/3T3 Cells With Catechol as Cocarcinogen&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;

1982 • 23 citations

Gastric and oesophageal carcinogenesis: Models for the identification of risk and protective factors

1986 • 23 citations

Hepatocellular Neoplasms in Rats Induced by Butylated Hydroxytoluene (BHT)

1983 • 23 citations

Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole.

1987 • 22 citations

Inhibitory Effect of Sodium Ascorbate on Ethylurea and Sodium Nitrite Carcinogenesis and Negative Findings in Progeny After Intestinal Inoculation of Precursors Into Pregnant Hamsters2

1975 • 22 citations

Differential Modification of Development of Preneoplastic Lesions in the Syrian Golden Hamster Initiated With a Single Dose of 2,2′-Dioxo-&lt;italic&gt;N&lt;/italic&gt;-nitrosodipropylamine: Influence of Subsequent Butylated Hydroxyanisole, α-Tocopherol, or Carbazole&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1987 • 21 citations

Combined effects of butylated hydroxyanisole and other antioxidants in induction of forestomach lesions in rats

1986 • 21 citations

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs

1987 • 20 citations

Effect of Various Levels of Dietary Butylated Hydroxyanisole on Methylazoxymethanol Acetate-Induced Colon Carcinogenesis in CF1 Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1983 • 20 citations

Initiating potential of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and 3,3′,4′,5,7-pentahydroxyflavone (quercetin) in two-stage mouse skin carcinogenesis

1987 • 20 citations

Food Additives, Safety, Effect of Feeding Butylated Hydroxyanisole to Dogs

1960 • 20 citations

Effects of Dietary Selenium on Bis(2-oxopropyl)nitrosamine-Induced Carcinogenesis in Syrian Golden Hamsters&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1986 • 20 citations

Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats

1988 • 18 citations

Distribution of butylated hydroxyanisole and its conjugates in the tissues of rats.

1981 • 17 citations

Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants

1987 • 17 citations

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces

1988 • 17 citations

Effects of antioxidants on aflatoxin-induced hepatic tumors in rats

1987 • 16 citations

The effect of antioxidants on MNNG-induced stomach carcinogenesis in rats

1986 • 16 citations

Excretion of Catechol in Human Urine

1959 • 16 citations

Ascorbic acid prevents liver tumour production by aminopyrine and nitrite in the rat

1977 • 15 citations

Effects of sodium l-ascorbate and related compounds on rat stomach carcinogenesis initiated by N-methyl-N′-nitro-N-nitrosoguanidine

1985 • 15 citations

Carcinogenesis Bioassay of Propyl Gallate in F344 Rats and B6C3FJ Mice

1983 • 15 citations

Modification of gastrointestinal tumor development in rats by dietary butylated hydroxytoluene*1

1987 • 14 citations

Effect of dietary selenium levels on methylbenzylnitrosamine-induced esophageal cancer in rats

1986 • 14 citations

Chapter 8: MODIFICATION OF CARCINOGENESIS BY ANTIOXIDANTS AND OTHER COMPOUNDS

1984 • 14 citations

Tissue distribution and pharmacokinetics of 3-t-[methyl-14C] butyl-4-hydroxyanisole in rats.

1985 • 14 citations

Kinetics of 3-tert-butyl-4-hydroxyanisole (BHA) in man

1984 • 14 citations

Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats

1987 • 14 citations

The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-N-propyl nitrosamine

1986 • 13 citations

Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil

1985 • 12 citations

Sodium erythorbate is not carcinogenic in F344 rats

1984 • 12 citations

GLC Determination of Butylated Hydroxyanisole in Human Plasma and Urine

1979 • 12 citations

Co‐carcinogenic Effect of Retinyl Acetate on Forestomach Carcinogenesis of Male F344 Rats Induced with Butylated Hydroxyanisole

1988 • 11 citations

Food and Cancer: Cause and Effect?

1986 • 11 citations

Effects of phenol and 2, 6-dimethoxyphenol (syringol) on in vivo formation of N-nitrosomorpholine in rats

1986 • 10 citations

AN ATTEMPT TO INHIBIT THE DEVELOPMENT OF TAR-CARCINOMA IN MICE: Preliminary Note.

1934 • 9 citations

Comparison of Lesions Induced in the Syrian Golden Hamster by Diethylnitrosamine, Dimethylhydrazine, and Dibutylnitrosamine: Influence of Subsequent Butylated Hydroxyanisole Treatment&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

1987 • 9 citations

Mechanism of butylated hydroxytoluene-associated modification of diethylnitrosamine-induced squamous stomach carcinoma

1984 • 9 citations

The absorption and excretion of butylated hydroxyanisole in beagle dogs

1985 • 8 citations

Inhibitory effect of α-tocopherol on the formation of nitrosomorpholine in mice treated with morpholine and exposed to nitrogen dioxide

1986 • 8 citations

Preventive Effect of Vitamin C (&lt;i&gt;L&lt;/i&gt;-Ascorbic Acid) on Methylcholanthrene-Induced Soft Tissue Sarcomas in Mice

1986 • 7 citations

Quantitative structure-activity relationship (QSAR) applications in chemical carcinogenesis. III. QSAR analysis of some phenolic antioxidants.

1985 • 4 citations