FK-506 — How much potential?

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

1987 • 1,216 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Structure of FK506, a novel immunosuppressant isolated from Streptomyces

1987 • 504 citations

STUDIES OF THE INDUCTION AND MAINTENANCE OF LONG-TERM GRAFT ACCEPTANCE BY TREATMENT WITH FK506 IN HETEROTOPIC CARDIAC ALLOTRANSPLANTATION IN RATS

1987 • 169 citations

STUDIES OF THE EFFECTS OF FK506 ON RENAL ALLOGRAFTING IN THE BEAGLE DOG

1987 • 137 citations

Paradoxical effects of cyclosporin A on collagen arthritis in rats.

1983 • 126 citations

PROLONGATION OF SKIN ALLOGRAFT SURVIVAL IN RATS BY A NOVEL IMMUNOSUPPRESSIVE AGENT, FK 506

1988 • 101 citations

Immunosuppressive effect of FK506 on collagen-induced arthritis in rats

1988 • 72 citations

PROLONGATION OF CARDIAC XENOGRAFT SURVIVAL IN RATS RECEIVING CYCLOSPORIN A

1981 • 50 citations

Amelioration of cyclosporin-induced nephrotoxicity in rats by induction of hepatic drug metabolism

1985 • 41 citations

Cyclosporine therapy of rat heart allograft recipients and release of interleukins (IL 1, IL 2, IL 3): a role for IL 3 in graft tolerance?

1984 • 40 citations

Spleen lymphocyte populations and expression of activation markers in rats treated with the potent new immunosuppressive agent FK-506.

1988 • 22 citations

II. Indefinite Survival and Development of Specific Immunologic Unresponsiveness12

1985 • 15 citations