Cancer cachexia

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Methods for growth of cultured cells in serum-free medium

1980 • 1,013 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

THE IMMEDIATE CAUSES OF DEATH IN CANCER

1932 • 418 citations

Stimulation of Intestinal Adenyl Cyclase by Cholera Toxin

1971 • 388 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Cachexia, the Metabolic Component of Neoplastic Diseases

2015 • 261 citations

Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removal

1980 • 260 citations

Anticachectin/tumor necrosis factor‐α antibodies attenuate development of cachexia in tumor models

1989 • 210 citations

Tumour necrosis factor in man: Clinical and biological observations

1987 • 205 citations

Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice.

1990 • 194 citations

Production of lipolytic and proteolytic factors by a murine tumor-producing cachexia in the host.

1987 • 163 citations

Tumor Necrosis Factor Not Detectable in Patients With Clinical Cancer Cachexia

1988 • 133 citations

Reduction of weight loss and tumour size in a cachexia model by a high fat diet

1987 • 125 citations

CANCER CACHEXIA AND GLUCONEOGENESIS

1974 • 124 citations

Parabiotic transfer of cancer anorexia/cachexia in male rats.

1985 • 121 citations

Inhibition of weight loss by omega-3 fatty acids in an experimental cachexia model.

1990 • 118 citations

Inhibition of tumour-induced lipolysis in vitro and cachexia and tumour growth in vivo by eicosapentaenoic acid

1991 • 116 citations

Characterization of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals.

1987 • 111 citations

Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism

1988 • 109 citations

Cachexia of malignancy.Potential role of insulin in nutritional management

1979 • 107 citations

Management of cancer cachexia.

1985 • 91 citations

Purification and characterization of a lipolytic factor (toxohormone-L) from cell-free fluid of ascites sarcoma 180.

1981 • 82 citations

A lipid mobilizing factor in serum of tumor‐bearing mice

1980 • 74 citations

Persistence of the hypertriglyceridemic effect of tumor necrosis factor despite development of tachyphylaxis to its anorectic/cachectic effects in rats.

1989 • 71 citations

Phospholipids containing polyunsaturated fatty acyl groups are mitogenic for normal mouse mammary epithelial cells in serum-free primary cell culture.

1989 • 62 citations

Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour

1988 • 62 citations

Nitrogen excretion in cancer cachexia and its modification by a high fat diet in mice.

1989 • 62 citations

Alteration of serum and urinary lipolytic activity with weight loss in cachectic cancer patients

1990 • 61 citations

Cachexia, gluconeogenesis and progressive weight loss in cancer patients

1978 • 58 citations

Tumor necrosis factor in children with malignancies.

1990 • 57 citations

Induction of weight loss and metabolic alterations by human recombinant tumour necrosis factor

1988 • 54 citations

Body composition changes in rats with experimental cancer cachexia: improvement with exogenous insulin.

1988 • 53 citations

Effect of insulin on weight loss and tumour growth in a cachexia model

1989 • 52 citations

Anorexia and cancer in animals and man

1980 • 49 citations

LUNG TUMORS: HOW THEY PRODUCE THEIR SYNDROMES*

1974 • 46 citations

A metabolic comparison of a pure long-chain triglyceride lipid emulsion (LCT) and various medium-chain triglyceride (MCT)-LCT combination emulsions in dogs

1987 • 41 citations

Characterization of a lipid mobilizing factor from tumors

1981 • 38 citations

Critical evaluation of the role of nutritional support with chemotherapy

1985 • 38 citations

Studies of high-dose megestrol acetate: potential applications in cachexia.

1988 • 37 citations

Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes.

1987 • 36 citations

Effect of nutritional status on response to therapy.

1982 • 34 citations

Lipolysis induction in adipocytes by a protein from tumor cells

1982 • 30 citations

Recombinant Tumor Necrosis Factor- Chronically Administered in Rats: Lack of Cachectic Effect

1990 • 28 citations

L-cyst(e)ine requirements of malignant cells and progress toward depletion therapy.

1979 • 28 citations

Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice

1990 • 27 citations

II. Effect of n-3 and n-6 fatty acids on mammary H-ras expression and PGE2 levels in DMBA-treated rats.

1989 • 25 citations

Effects of tumor type and burden on carcass lipid depletion in mice.

1986 • 25 citations

Blood nutrient concentrations and tumor growth in vivo in rats: relationships during the onset of an acute fast.

1987 • 23 citations

An Experimental Model of Cachexia Induced by a Xenografted Human Tumor

1980 • 21 citations

Tumoricidal potential of nutritional manipulations.

1982 • 20 citations

Effect of methionine replacement by homocysteine on the growth of cells

1980 • 17 citations

Tumour induction of host leucine starvation

1981 • 16 citations

Basis for the Serine Requirement in Leukemic and Normal Human Leukocytes. Reduced Levels of the Enzymes in the Phosphorylated Pathway<xref ref-type="fn" rid="FN2">2</xref>

1972 • 14 citations

Lessons from the study of induced alterations in amino acids in patients with cancer.

1979 • 7 citations