Effects of chronic caffeine on adenosine, dopamine and acetylcholine systems in mice.

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects

1992 • 1,392 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

1983 • 455 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

Adenosine-dopamine interactions in the brain

1992 • 366 citations

Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites

1983 • 258 citations

Downregulation of nicotinic receptor function after chronic nicotine infusion.

1993 • 181 citations

Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain

1993 • 162 citations

Interactions in the behavioral effects of methylxanthines and adenosine derivatives.

1983 • 128 citations

A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase.

1992 • 115 citations

Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.

1991 • 111 citations

Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.

1986 • 105 citations

Dopamine denervation leads to an increase in the intramembrane interaction between adenosine A2 and dopamine D2 receptors in the neostriatum

1992 • 104 citations

Locomotor activity in mice during chronic treatment with caffeine and withdrawal

1993 • 98 citations

Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.

1988 • 72 citations

Caffeine down-regulates β adrenoreceptors in rat forebrain

1982 • 69 citations

Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain

1988 • 55 citations

Behavioral interaction of adenosine and methylxanthines on central purinergic systems

1984 • 47 citations

Up-regulation of brain [3H]diazepam binding sites in chronic caffeine-treated rats

1984 • 43 citations

Changes in noradrenaline release and in beta receptor number in rat hippocampus following long‐term treatment with theophylline or L‐phenylisopropyladenosine

1984 • 38 citations

Tolerance and sensitization to chronic and subchronic oral caffeine: Effects of wheelrunning in rats

1990 • 31 citations

Quantitative analysis of multiple kappa-opioid receptors by selective and nonselective ligand binding in guinea pig spinal cord: resolution of high and low affinity states of the kappa 2 receptors by a computerized model-fitting technique.

1990 • 29 citations

Chronic effects of ethanol on central adenosine function of mice

1994 • 24 citations

A simple liquid-chromatographic method applied to determine caffeine in plasma and tissues.

1988 • 21 citations

Effects of combinations of methylxanthines and adenosine analogs on locomotor activity in control and chronic caffeine‐treated mice

1993 • 19 citations

Caffeine withdrawal affects central adenosine receptors but not benzodiazepine receptors

1989 • 17 citations

Acute treatment of mice with high doses of caffeine: An animal model for choreiform movement

1993 • 12 citations