Folding mechanism of mutant human lysozyme C77/95A with increased secretion efficiency in yeast.

The molten globule state as a clue for understanding the folding and cooperativity of globular‐protein structure

1989 • 1,446 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Mapping the transition state and pathway of protein folding by protein engineering

1989 • 699 citations

Transient folding intermediates characterized by protein engineering

1990 • 446 citations

Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.

1988 • 445 citations

The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell

1990 • 372 citations

Refinement of human lysozyme at 1.5 Å resolution analysis of non-bonded and hydrogen-bond interactions

1981 • 276 citations

Evidence for identity between the equilibrium unfolding intermediate and a transient folding intermediate: a comparative study of the folding reactions of .alpha.-lactalbumin and lysozyme

1986 • 254 citations

Demonstration by NMR of folding domains in lysozyme

1991 • 246 citations

Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis

1989 • 182 citations

Folding of staphylococcal nuclease A studied by equilibrium and kinetic circular dichroism spectra

1991 • 115 citations

Identification and characterization of the direct folding process of hen egg-white lysozyme

1982 • 65 citations

An early intermediate of refolding α‐lactalbumin forms within 20 ms

1987 • 54 citations

Role of disulfide bonds in folding and secretion of human lysozyme in saccharomycescerevisiae

1988 • 53 citations

The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast

1991 • 51 citations

Effects of proline mutations on the unfolding and refolding of human lysozyme: the slow refolding kinetic phase does not result from proline cis-trans isomerization

1991 • 49 citations

Evidence for difference in the roles of two cysteine residues involved in disulfide bond formation in the folding of human lysozyme.

1990 • 38 citations

Secretion in yeast of mutant human lysozymes with and without glutathione bound to cysteine 95.

1990 • 25 citations

Effect of an engineered disulfide bond on the folding of T4 lysozyme at low temperatures

1990 • 12 citations