Timing Deficits in Aging and Neuropathology

Scalar expectancy theory and Weber's law in animal timing.

1977 • 2,040 citations

What makes us tick? Functional and neural mechanisms of interval timing

2005 • 1,977 citations

Psychology of Learning and Motivation

1975 • 1,791 citations

Scalar Timing in Memory

1984 • 1,711 citations

Disruption of Large-Scale Brain Systems in Advanced Aging

2007 • 1,563 citations

Temporal discrimination and the indifference interval: Implications for a model of the "internal clock".

1963 • 1,398 citations

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

2001 • 1,293 citations

Models of Information Processing in the Basal Ganglia

1994 • 1,152 citations

Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience

1996 • 1,140 citations

Time, rate, and conditioning.

2000 • 1,066 citations

Neuropharmacology of timing and time perception

1996 • 907 citations

Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes

2004 • 849 citations

The Nature of the Physical World

1928 • 826 citations

Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimaging

2003 • 815 citations

Age-Related Differences in Neural Activity during Memory Encoding and Retrieval: A Positron Emission Tomography Study

1997 • 815 citations

Toward a neurobiology of temporal cognition: advances and challenges

1997 • 768 citations

Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection

2004 • 662 citations

Functional Anatomy of the Attentional Modulation of Time Estimation

2004 • 636 citations

Selective adjustment of the speed of internal clock and memory processes.

1983 • 615 citations

Functional and Neural Mechanisms of Interval Timing

2003 • 519 citations

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- <scp>l</scp> -carnitine and/or R -α-lipoic acid

2002 • 510 citations

Hyperactivity and impaired response habituation in hyperdopaminergic mice

2001 • 486 citations

The time of our lives: Life span development of timing and event tracking.

2006 • 478 citations

Cognitive processing and time perception

1975 • 477 citations

Cholinergic interneuron characteristics and nicotinic properties in the striatum

2002 • 428 citations

Coupled Temporal Memories in Parkinson's Disease: A Dopamine-Related Dysfunction

1998 • 423 citations

Hippocampus, time, and memory.

2013 • 420 citations

TEMPORAL DISCRIMINATION IS ABNORMAL IN PARKINSON'S DISEASE

1992 • 398 citations

Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease

2005 • 394 citations

Tests of an equivalence rule for fixed and variable reinforcer delays.

1984 • 391 citations

Expression, control, and probable functional significance of the neuronal theta-rhythm

1995 • 389 citations

From physical time to the first and second moments of psychological time.

2001 • 386 citations

Effects of aging and task difficulty on divided attention performance.

1988 • 382 citations

Application of scalar timing theory to individual trials.

1994 • 368 citations

Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems

2006 • 355 citations

Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.

2003 • 353 citations

Neuropsychology of timing and time perception

2004 • 346 citations

Scalar expectancy theory and peak-interval timing in humans.

1998 • 343 citations

Dissecting the Brain's Internal Clock: How Frontal–Striatal Circuitry Keeps Time and Shifts Attention

2002 • 329 citations

A Drosophila model for age-associated changes in sleep:wake cycles

2006 • 323 citations

Memory reprocessing in corticocortical and hippocampocortical neuronal ensembles

1997 • 320 citations

Methamphetamine and time estimation.

1981 • 311 citations

Application of scalar timing theory to individual trials.

1994 • 305 citations

Chemistry of the mind: Neurochemical modulation of prefrontal cortical function

2005 • 289 citations

Temporal information processing in ADHD: Findings to date and new methods

2005 • 289 citations

The differential effects of haloperidol and methamphetamine on time estimation in the rat

1983 • 286 citations

Time and Free Will

1889 • 281 citations

Contributions to the analysis of the sensations.

1897 • 281 citations

Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock

1986 • 272 citations

Models of information processing in the basal Ganglia

1995 • 271 citations

Dopaminergic Mechanisms in Actions and Habits: Figure 1.

2007 • 267 citations

Attention and the frontal cortex as examined by simultaneous temporal processing

1988 • 263 citations

Methamphetamine and time estimation.

1981 • 243 citations

Time left: Linear versus logarithmic subjective time.

1981 • 241 citations

fMRI Biomarker of Early Neuronal Dysfunction in Presymptomatic Huntington’s Disease

2004 • 235 citations

Basal ganglia and supplementary motor area subtend duration perception: an fMRI study

2003 • 234 citations

Sense of time in children with ADHD: Effects of duration, distraction, and stimulant medication

1997 • 234 citations

An integrated theory of prospective time interval estimation: The role of cognition, attention, and learning.

2007 • 229 citations

Switching or gating? The attentional challenge in cognitive models of psychological time

1998 • 227 citations

Local circuit neurons.

1975 • 224 citations

Age-related changes in multiple neurotransmitter systems in the monkey brain

1989 • 222 citations

Acetylcholine systems and rhythmic activities during the waking–sleep cycle

2004 • 220 citations

Human aging and duration judgments: A meta-analytic review.

1998 • 220 citations

Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD).

1996 • 220 citations

Sleep and memory: a molecular perspective

2001 • 218 citations

Differential effects of methamphetamine and haloperidol on the control of an internal clock.

2002 • 212 citations

Book Review: How Do We Tell Time?

2002 • 211 citations

Cholinergic modulation of the content of temporal memory.

1987 • 210 citations

Differential effects of methamphetamine and haloperidol on the control of an internal clock.

2002 • 201 citations

Human aging and duration judgments: A meta-analytic review.

1998 • 201 citations

The Functional Neuroanatomy of Temporal Discrimination

2004 • 198 citations

Processing of temporal information and the basal ganglia: new evidence from fMRI

2003 • 197 citations

Separating Storage from Retrieval Dysfunction of Temporal Memory in Parkinson's Disease

2002 • 196 citations

Neural representation of interval encoding and decision making

2004 • 195 citations

fMRI studies of temporal attention: allocating attention within, or towards, time

2004 • 193 citations

Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model

1992 • 183 citations

Cholinergic Interneurons Control the Excitatory Input to the Striatum

2007 • 181 citations

Scalar expectancy theory and choice between delayed rewards.

1988 • 179 citations

Neuromodulation, theta rhythm and rat spatial navigation

2002 • 175 citations

Division of attention: Age differences on a visually presented memory task

1984 • 173 citations

Not “just” a coincidence: Frontal‐striatal interactions in working memory and interval timing

2004 • 171 citations

Attentional Bias between Modalities: Effect on the Internal Clock, Memory, and Decision Stages Used in Animal Time Discrimination^a

1984 • 171 citations

Trace Conditioning and the Hippocampus: The Importance of Contiguity

2006 • 169 citations

Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions

2006 • 166 citations

Frontal–striatal circuitry activated by human peak-interval timing in the supra-seconds range

2004 • 166 citations

Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats

1997 • 163 citations

Cholinergic modulation of the content of temporal memory.

1987 • 161 citations

Paying Attention to Time as one Gets Older

2001 • 156 citations

The roles of the cerebellum and basal ganglia in timing and error prediction

2002 • 154 citations

Aging and judgments of duration: Effects of task complexity and method of estimation

1999 • 150 citations

The Substantia Nigra Pars Compacta and Temporal Processing

2006 • 148 citations

Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities

2004 • 147 citations

Impulsivity

2000 • 145 citations

Functional neural circuits for mental timekeeping

2006 • 141 citations

Le développement de la notion de temps chez l'enfant

1946 • 140 citations

A right hemispheric frontocerebellar network for time discrimination of several hundreds of milliseconds

2003 • 135 citations

Effects of dopamine antagonists on the timing of two intervals

2003 • 134 citations

Developmental changes in time estimation: Comparing childhood and old age.

1999 • 133 citations

Temporal processing dysfunction in schizophrenia

2008 • 133 citations

Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing

2006 • 131 citations

Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events

2002 • 131 citations

Time estimation in schizophrenia: an fMRI study at adjusted levels of difficulty

2001 • 126 citations

Time perception depends on accurate clock mechanisms as well as unimpaired attention and memory processes

2004 • 124 citations

Developmental changes in time estimation: Comparing childhood and old age.

1999 • 124 citations

Duration judgements in patients with schizophrenia

2003 • 124 citations

Age and IQ effects on stimulus and response timing.

1997 • 124 citations

Interval-timing deficits in individuals at high risk for schizophrenia

2004 • 122 citations

Dissociating brain regions controlling the temporal and ordinal structure of learned movement sequences

2004 • 121 citations

The biology of time across different scales

2007 • 119 citations

Systems-level integration of interval timing and reaction time

2004 • 116 citations

Optimal foraging and timing processes in the starling, Sturnus vulgaris: effect of inter-capture interval

1992 • 107 citations

Modulation of an Afterhyperpolarization by the Substantia Nigra Induces Pauses in the Tonic Firing of Striatal Cholinergic Interneurons

2004 • 106 citations

Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing

2006 • 105 citations

Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timing

2004 • 105 citations

Interval timing with gaps and distracters: Evaluation of the ambiguity, switch, and time-sharing hypotheses.

2006 • 105 citations

Relationships Between Age-Related Changes in Time Estimation and Age-Related Changes in Processing Speed, Attention, and Memory

2002 • 105 citations

Impaired Temporal Discrimination in Parkinson's Disease: Temporal Processing of Brief Durations as an Indicator of Degeneration of Dopaminergic Neurons in the Basal Ganglia

1997 • 103 citations

Cholinergic and dopaminergic modulation of potassium conductances in neostriatal neurons.

1993 • 103 citations

Conference

1999 • 103 citations

Differential effects of clozapine and haloperidol on interval timing in the supraseconds range

2005 • 100 citations

Interneurons in the rat striatum: relationships between parvalbumin neurons and cholinergic neurons

1992 • 100 citations

Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation

2002 • 97 citations

Scalar Timing in Animals and Humans

2002 • 96 citations

Ketamine “unlocks” the reduced clock-speed effects of cocaine following extended training: Evidence for dopamine–glutamate interactions in timing and time perception

2007 • 95 citations

Discrimination of temporal information at the cerebellum: functional magnetic resonance imaging of nonverbal auditory memory

2003 • 93 citations

Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory

1986 • 93 citations

Auditory/visual duration bisection in patients with left or right medial-temporal lobe resection

2004 • 90 citations

Paradoxical REM sleep promoting and permitting neuronal networks.

2004 • 89 citations

Categorical Scaling of Duration Bisection in Pigeons (Columba livia), Mice (Mus musculus), and Humans (Homo sapiens)

2008 • 88 citations

Temporal Bisection in Humans with Longer Stimulus Durations

1997 • 83 citations

Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson’s disease

2005 • 81 citations

Neural Basis of Temporal Context Memory: A Functional MRI Study

2002 • 79 citations

Neuroimaging of interval timing

2004 • 78 citations

Attentional Time-Sharing in Interval Timing

2003 • 76 citations

Assessment of time perception: The effect of aging

2004 • 75 citations

Gating or switching? Gating is a better model of prospective timing (a response to ‘switching or gating?’ by Lejeune)

2000 • 74 citations

The ‘internal clocks’ of circadian and interval timing

1997 • 72 citations

Brain activation in processing temporal sequence: an fMRI study

2004 • 71 citations

Habit formation and the loss of control of an internal clock: inverse relationship between the level of baseline training and the clock-speed enhancing effects of methamphetamine

2007 • 70 citations

TIME ESTIMATION AMONG SCHIZOPHRENICS

1980 • 69 citations

Estimation of Short Temporal Intervals in Alzheimer's Disease

2000 • 68 citations

Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior

2008 • 68 citations

Temporal integration as a function of signal and gap intensity in rats (Rattus norvegicus) and pigeons (Columba livia).

2002 • 68 citations

Identification of Tone Duration, Line Length, and Letter Position: An Experimental Approach to Timing and Working Memory Deficits in Schizophrenia.

2004 • 68 citations

Timing in Aging: The Role of Attention

1999 • 66 citations

Choline Uptake in the Frontal Cortex Is Proportional to the Absolute Error of a Temporal Memory Translation Constant in Mature and Aged Rats

2002 • 66 citations

Visuotactile temporal order judgments in ageing

2005 • 62 citations

Role of hypokinesia and bradykinesia in gait disturbances in Huntington's disease

2005 • 59 citations

Analysis of recurrent cortico-basal ganglia-thalamic loops for working memory

2000 • 59 citations

Time Perception and Schizophrenia

1977 • 57 citations

Effects of aging on absolute identification of duration.

2002 • 57 citations

The ‘internal clocks’ of circadian and interval timing ( erratum )

1997 • 55 citations

Time Estimation by Healthy Subjects and Schizophrenic Patients: A Methodological Study

1983 • 49 citations

Behavioral and Electrophysiological Indices of Temporal Processing Dysfunction in Schizophrenia

2005 • 47 citations

“Speed” Warps Time: Methamphetamines Interactive Roles in Drug Abuse, Habit Formation, and the Biological Clocks of Circadian and Interval Timing

2008 • 46 citations

Neurons in the lateral agranular frontal cortex have divided attention correlates in a simultaneous temporal processing task

2001 • 44 citations

Interaction of raclopride and preparatory interval effects on simple reaction time performance

2006 • 43 citations

Pacemaker neurons of the forebrain medical septal area and theta rhythm of the hippocampus.

1998 • 43 citations

Altered Subjective Time of Events in Schizophrenia

2005 • 43 citations

Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition

2006 • 42 citations

Parkinson's Disease and Sleep

2005 • 42 citations

Grandfather’s Clock

2003 • 41 citations

The effects of aging on time reproduction in delayed free-recall

2004 • 41 citations

Effects of a 5-HT2 receptor agonist, DOI (2,5-dimethoxy-4-iodoamphetamine), and antagonist, ketanserin, on the performance of rats on a free-operant timing schedule

2003 • 40 citations

Pharmacology of Temporal Cognition in Two Mouse Strains

2001 • 37 citations

How cells tell time

1998 • 37 citations

A firing rate model of Parkinsonian deficits in interval timing

2006 • 36 citations

Age-related differences in timing with breaks.

2007 • 36 citations

Effects of Age on Long-term Memory: Retention of Fixed Interval Responding

1981 • 35 citations

Animal cognition and sequential behavior : behavioral, biological, and computational perspectives

2002 • 34 citations

Effect of lesions of the ascending 5-hydroxytryptaminergic pathways on timing behaviour investigated with the fixed-interval peak procedure

1994 • 33 citations

Effects of fenfluramine on free-operant timing behaviour: evidence for involvement of 5-HT2A receptors

2004 • 32 citations

Dopamine and basal ganglia disorders in humans

1992 • 31 citations

Value of food aggregates: parallel versus serial discounting

1995 • 30 citations

Interval Timing in the Dopamine-Depleted Basal Ganglia

2003 • 30 citations

Effects of 5-HT2A receptor stimulation on the discrimination of durations by rats

2005 • 30 citations

Single-dose Levodopa Administration and Aging Independently Disrupt Time Production

2006 • 30 citations

Prospective timing, attention and the switch

2000 • 29 citations

Trace eyeblink conditioning in decerebrate guinea pigs

2003 • 28 citations

Effects of muscarinic acetylcholine receptor activation on membrane currents and intracellular messengers in medium spiny neurones of the rat striatum

2004 • 27 citations

Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors

2006 • 26 citations

Evidence for a role of D1 dopamine receptors in d-amphetamine’s effect on timing behaviour in the free-operant psychophysical procedure

2006 • 26 citations

Choice between fixed and variable delays with different reward amounts.

1994 • 26 citations

Interval Timing and Genomics: What Makes Mutant Mice Tick?

2001 • 25 citations

Compositionality in language and arithmetic.

2007 • 25 citations

Single-dose Levodopa Administration and Aging Independently Disrupt Time Production

2006 • 25 citations

Timing Competence and Timing Performance: A Cross‐Species Approach

1984 • 22 citations

Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour

2005 • 20 citations

Time Estimation among Schizophrenics

1980 • 20 citations

Distortions in the Content of Temporal Memory

2002 • 17 citations

Regionally Selective Manifestations of Neostriatal Aging

1988 • 16 citations

Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors

2005 • 14 citations

Effects of feedback on time production errors in aging participants

2007 • 14 citations

Temporal Information Processing by Young and Senior Adults and Patients With Senile Dementia

1975 • 14 citations

Importance of Frontal Motor Cortex in Divided Attention and Simultaneous Temporal Processing

2003 • 11 citations

Tonic rhythmic activity of rat cerebellar neurons

2002 • 8 citations

Neurogenetics of Interval Timing

2003 • 6 citations

[Disintegration of the elements of time in the degenerative dementias of old age].

1967 • 5 citations