“Speed” Warps Time: Methamphetamines Interactive Roles in Drug Abuse, Habit Formation, and the Biological Clocks of Circadian and Interval Timing

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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

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The role of the basal ganglia in habit formation

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What makes us tick? Functional and neural mechanisms of interval timing

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2000 • 1,186 citations

Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction

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Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers

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Neuropharmacology of timing and time perception

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Low Level of Brain Dopamine D₂ Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex

2001 • 901 citations

Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes

2004 • 849 citations

Toward a neurobiology of temporal cognition: advances and challenges

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Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria

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Selective adjustment of the speed of internal clock and memory processes.

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Drug addiction: bad habits add up

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Decision making, impulsivity and time perception

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Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment

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Neuropsychological mechanisms of interval timing behavior

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Regulation of dopaminergic transmission and cocaine reward by the Clock gene

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Cocaine sensitization and reward are under the influence of circadian genes and rhythm

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Amphetamine Exposure Enhances Habit Formation

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Coupled Temporal Memories in Parkinson's Disease: A Dopamine-Related Dysfunction

1998 • 423 citations

Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.

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Reinforcement Learning Signals in the Human Striatum Distinguish Learners from Nonlearners during Reward-Based Decision Making

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Evidence for long-term neurotoxicity associated with methamphetamine abuse

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Application of scalar timing theory to individual trials.

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Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals

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Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems

2006 • 355 citations

Neuropsychological Effects of Chronic Methamphetamine Use on Neurotransmitters and Cognition: A Review

2003 • 354 citations

Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.

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Neuropsychology of timing and time perception

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Scalar expectancy theory and peak-interval timing in humans.

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Human bisection at the geometric mean

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SPECT imaging of striatal dopamine release after amphetamine challenge.

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Dissecting the Brain's Internal Clock: How Frontal–Striatal Circuitry Keeps Time and Shifts Attention

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Cognitive Impairment in Individuals Currently Using Methamphetamine

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Methamphetamine and time estimation.

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The differential effects of haloperidol and methamphetamine on time estimation in the rat

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Neuropharmacological evidence for different timing mechanisms in humans.

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Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock

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Dopaminergic Mechanisms in Actions and Habits: Figure 1.

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Role of Dopamine Transporter in Methamphetamine-Induced Neurotoxicity: Evidence from Mice Lacking the Transporter

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Model of Cortical-Basal Ganglionic Processing: Encoding the Serial Order of Sensory Events

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Dopamine Modulates Release from Corticostriatal Terminals

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Effects of psilocybin on time perception and temporal control of behaviour in humans

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Differential effects of methamphetamine and haloperidol on the control of an internal clock.

2002 • 212 citations

On the form and location of the Psychometric Bisection Function for time

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Mechanisms of methamphetamine-induced dopaminergic neurotoxicity

2006 • 188 citations

Not “just” a coincidence: Frontal‐striatal interactions in working memory and interval timing

2004 • 171 citations

Impaired time perception and motor timing in stimulant-dependent subjects

2007 • 169 citations

Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions

2006 • 166 citations

Frontal–striatal circuitry activated by human peak-interval timing in the supra-seconds range

2004 • 166 citations

Differential Modulation of Clock Speed by the Administration of Intermittent Versus Continuous Cocaine.

2004 • 154 citations

Amphetamine neurotoxicity: accomplishments and remaining challenges

2004 • 145 citations

Effects of dopamine antagonists on the timing of two intervals

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Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing

2006 • 131 citations

Repeated binge exposures to amphetamine and methamphetamine: behavioral and neurochemical characterization.

1997 • 128 citations

Extended Habit Training Reduces Dopamine Mediation of Appetitive Response Expression

2005 • 123 citations

Methamphetamine-Induced Neurotoxicity Alters Locomotor Activity, Stereotypic Behavior, and Stimulated Dopamine Release in the Rat

1999 • 122 citations

Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge

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Methamphetamine neurotoxicity: Dissociation of striatal dopamine terminal damage from parietal cortical cell body injury

1998 • 117 citations

Systems-level integration of interval timing and reaction time

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Impaired Object Recognition Memory Following Methamphetamine, but not p-Chloroamphetamine- or d-Amphetamine-Induced Neurotoxicity

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Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine

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Symmetrical and asymmetrical sources of variance in temporal generalization

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The Methamphetamine-Sensitive Circadian Oscillator (MASCO) in Mice

2006 • 106 citations

Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing

2006 • 105 citations

Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timing

2004 • 105 citations

Conference

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Differential effects of clozapine and haloperidol on interval timing in the supraseconds range

2005 • 100 citations

Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine

2001 • 98 citations

Ketamine “unlocks” the reduced clock-speed effects of cocaine following extended training: Evidence for dopamine–glutamate interactions in timing and time perception

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Dopamine-glutamate interactions in methamphetaminc-induced neurotoxicity

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Drug Tolerance, Drug Addiction, and Drug Anticipation

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Auditory/visual duration bisection in patients with left or right medial-temporal lobe resection

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Methamphetamine‐induced neural and cognitive changes in rodents

2007 • 78 citations

Effects of methamphetanine on duration discrimination.

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Amygdala inactivation reverses fear's ability to impair divided attention and make time stand still.

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Marijuana and ethanol: Differential effects on time perception, heart rate, and subjective response

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The ‘internal clocks’ of circadian and interval timing

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Dopaminergic Mechanisms of Interval Timing and Attention

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Habit formation and the loss of control of an internal clock: inverse relationship between the level of baseline training and the clock-speed enhancing effects of methamphetamine

2007 • 70 citations

Norepinephrine loss exacerbates methamphetamine-induced striatal dopamine depletion in mice

1995 • 69 citations

Aging increases the susceptiblity to methamphetamine‐induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia

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Striatal and cortical NMDA receptors are altered by a neurotoxic regimen of methamphetamine

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Clonidine-induced antagonism of norepinephrine modulates the attentional processes involved in peak-interval timing.

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Modality-specific circadian rhythmicities influence mechanisms of attention and memory for interval timing

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Daily Meal Anticipation: Interaction of Circadian and Interval Timing^a

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Common Representations of Abstract Quantities

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Relation between methamphetamine-induced monoamine depletions in the striatum and sequential motor learning

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Interval timing in mice does not rely upon the circadian pacemaker

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Methamphetamine induced locomotor rhythm entrains to restricted daily feeding in SCN lesioned rats

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Impairments in timing, temporal memory, and reversal learning linked to neurotoxic regimens of methamphetamine intoxication

2007 • 45 citations

Impairment in Consolidation of Learned Place Preference Following Dopaminergic Neurotoxicity in Mice is Ameliorated by N-acetylcysteine but not D1 and D2 Dopamine Receptor Agonists

2006 • 44 citations

Interaction of raclopride and preparatory interval effects on simple reaction time performance

2006 • 43 citations

Differential Effects of Amphetamines-Induced Neurotoxicity on Appetitive and Aversive Pavlovian Conditioning in Mice

2005 • 43 citations

α7 Nicotinic acetylcholine receptors and temporal memory: Synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock

2006 • 43 citations

Effect of clozapine on interval timing and working memory for time in the peak-interval procedure with gaps

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Circadian variations in time perception in rats

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Behavioral Consequences of Methamphetamine‐Induced Neurotoxicity in Mice: Relevance to the Psychopathology of Methamphetamine Addiction

2002 • 37 citations

The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication

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Cannabinoid modulation of sensitivity to time

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Endogenous oscillations in short-interval timing

2006 • 29 citations

A “Good Parent” Function of Dopamine

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Dopamine receptor antagonists reverse amphetamine-induced behavioral alteration on a differential reinforcement for low-rate (DRL) operant task in the rat.

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Noradrenergic modulation of methamphetamine-induced striatal dopamine depletion.

1998 • 23 citations

Acute effects of d-amphetamine on the differential reinforcement of low-rate (DRL) schedule behavior in the rat: comparison with selective dopamine receptor antagonists.

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Acute Ethanol Potentiates the Clock‐Speed Enhancing Effects of Nicotine on Timing and Temporal Memory

2007 • 22 citations

Evidence for separate neural mechanisms for the timing of discrete and sustained responses

2007 • 22 citations

Increasing the speed of an internal clock: The effects of nicotine on interval timing

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Combined organizational and activational effects of short and long photoperiods on spatial and temporal memory in rats

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Effects of the NMDA receptor antagonist MK-801 on short-interval timing in rats.

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Estradiol modulation of the speed of an internal clock.

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Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour

2005 • 20 citations

Pharmacological manipulations of food protection behavior in rats: Evidence for dopaminergic contributions to time perception during a natural behavior

2006 • 16 citations

Frontal decortication eliminates drug-induced ascorbic acid release in the striatum but not the nucleus accumbens of freely moving rats

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Methamphetamine induces circadian oscillation in the brain outside the suprachiasmatic nucleus in rats

2007 • 9 citations